FTO in oral diseases: Functions, mechanisms, and therapeutic potential DOI Open Access
Biao Li, Leilei Wang, Min Quan Du

et al.

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(20)

Published: Oct. 22, 2024

Abstract Fat mass and obesity‐associated protein (FTO) is the first identified N 6 ‐methyladenosine (m A) demethylase widely distributed in various tissues adults children. It plays an essential role diverse mRNA‐associated processes including transcriptional stability, selective splicing, mRNA translocation, also translation. Recently, emerging studies have shown that FTO involved genesis development of oral diseases. However, correlation between diseases its specific regulatory mechanism still needs further study. In this review, we will summarize discovery, distribution, gene expression, structure, biological functions, inhibitors, quantifying methods FTO, as well Notably, genetic variants are strongly associated with periodontal (PDs), temporomandibular joint osteoarthritis (TMJOA), obstructive sleep apnea (OSA). Besides, latest describe relationship PDs, head neck squamous cell carcinoma (HNSCCs), TMJOA, OSA be discussed. We elaborate on roles HNSCCs, which modulated through proliferation, migration, apoptosis, bone metabolism, immune response. The review enrich our understanding RNA epigenetic modifications present a solid theoretical foundation for to serve novel diagnosis prognostic biomarker

Language: Английский

Injectable hyperbranched PEG crosslinked hyaluronan hydrogel microparticles containing mir-99a-3p modified subcutaneous ADSCs-derived exosomes was beneficial for long-term treatment of osteoarthritis DOI Creative Commons
Zhaowei Yin, Chaoren Qin, Shaowei Pan

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100813 - 100813

Published: Sept. 28, 2023

Exosomes (Exos) secreted by adipose-derived stem cells (ADSCs) have shown potential in alleviating osteoarthritis (OA). Previous studies indicated that infrapatellar fat pad (IPFP) derived (IPFSCs) may be more suitable for the treatment of OA than subcutaneous adipose tissue (ScAT) (ScASCs). However, it remains unclear which type Exos offers superior therapeutic benefit OA. This study first compared differences between from IPFP (ExosIPFP) and ScAT (ExosScAT) treatment. Results suggested ExosIPFP significantly inhibit degradation cartilage extracellular matrix (ECM) ExosScAT, following this, microRNA (miRNA) expression two types using small RNA sequencing were performed. Subsequently, miR-99 b-3p was chosen over-expressed ExosScAT (ExosScAT−99b−3p), both vivo vitro experiments demonstrated its efficacy inhibiting ADAMTS4, promoting repair ECM Finally, microfluidic technology performed to fabricate a hyaluronan-based hydrogel microparticles (HMPs) encapsulating (HMPs@exos), injectability, sustained release long-term effect on validated. In summary, these results suggest regulates targeting upregulation would enable them exhibit comparable or even effectiveness treatment, making promising approach Considering abundant resources limited availability IPFP, harvested through liposuction could genetically engineered yield Furthermore, encapsulation HMPs provides an injectable local drug system, potentially enhance hold as future strategies.

Language: Английский

Citations

30
Mechanistic and therapeutic insights into the function of N6-methyladenosine in arthritic diseases DOI
Xinyue Zhou,

Yajie Wu,

Yingqiu Song

et al.

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: Jan. 7, 2025

Language: Английский

Citations

1
Epigenetics in Knee Osteoarthritis: A 2020–2023 Update Systematic Review DOI Creative Commons
Davide Caldo,

Eugenia Massarini,

Massimiliano Rucci

et al.

Life, Journal Year: 2024, Volume and Issue: 14(2), P. 269 - 269

Published: Feb. 17, 2024

Osteoarthritis is a leading cause of disability in the world. The scientific literature highlights critical importance epigenetic regulatory effects, intertwined with biomechanical and biochemical peculiar conditions within each musculoskeletal district. While contribution genetic factors to knee OA well-recognized, their precise role disease management remains an area active research. Such field particularly heterogeneous, calling for regular analysis summarizing data that constantly emerge literature, often sparse scant integration. aim this study was systematically identify synthesize all new evidence emerged human animal model studies published between 2020 2023. This necessary because, best our knowledge, articles before 2019 (and partly 2020) had already been included systematic reviews allowed ones concerning joint. review carried out accordance Preferential Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines. Only peer-reviewed were considered inclusion. A total 40 identified, showing promising results terms either biomarker identification, insight mechanism action or potential therapeutic targets OA. DNA methylation, histone modification ncRNA mechanisms involved regulation knee. Most recent suggests epigenetics most long-term goal improving understanding OA, but variety research approaches need greater consolidation.

Language: Английский

Citations

7
miR-708–5p deficiency involves the degeneration of mandibular condylar chondrocytes via the TLR4/NF-κB pathway DOI
Lingfeng Xu, Yuejiao Zhang, Jia Yu

et al.

Osteoarthritis and Cartilage, Journal Year: 2024, Volume and Issue: 32(6), P. 666 - 679

Published: Feb. 23, 2024

Language: Английский

Citations

7
Exosomes derived from 3D-cultured MSCs alleviate knee osteoarthritis by promoting M2 macrophage polarization through miR-365a-5p and inhibiting TLR2/Myd88/NF-κB pathway DOI
Lei Yan,

Dijun Li,

Songyan Li

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154432 - 154432

Published: July 30, 2024

Language: Английский

Citations

6
Recent advances of m6A methylation in skeletal system disease DOI Creative Commons

Jian‐Hui Liang,

Qian Yi,

Yang Liu

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 14, 2024

Abstract Skeletal system disease (SSD) is defined as a class of chronic disorders skeletal with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 position adenosine in RNA, reversible dynamic modification posttranscriptional mRNA. Evidences suggest that m6A modifications play crucial role regulating biological processes all kinds diseases, such malignancy. Recently studies have revealed most abundant epigentic modification, involved progression SSD. However, function SSD not fully illustrated. Therefore, make clear relationship between pathogenesis might provide novel sights for prevention targeted treatment This article will summarize recent advances regulation SSD, including osteoporosis, osteosarcoma, rheumatoid arthritis osteoarthritis, discuss potential clinical value, research challenge future prospect

Language: Английский

Citations

5
Roles of RNA Methylations in Cancer Progression, Autophagy, and Anticancer Drug Resistance DOI Open Access

Hyein Jo,

Kyeonghee Shim,

Dooil Jeoung

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 4225 - 4225

Published: Feb. 20, 2023

RNA methylations play critical roles in processes, including splicing, nuclear export, nonsense-mediated decay, and translation. Regulators of have been shown to be differentially expressed between tumor tissues/cancer cells adjacent tissues/normal cells. N6-methyladenosine (m6A) is the most prevalent internal modification RNAs eukaryotes. m6A regulators include writers, demethylases, binding proteins. Since important regulating expression oncogenes suppressor genes, targeting can a strategy for developing anticancer drugs. Anticancer drugs are clinical trials. regulator-targeting could enhance effects current chemotherapy This review summarizes cancer initiation progression, autophagy, drug resistance. The also discusses relationship autophagy resistance, effect high levels on potential values as diagnostic markers therapeutic targets.

Language: Английский

Citations

11
Nuclear receptor 4A1 inhibits chondrocyte inflammation and cartilage degeneration in osteoarthritis by inhibiting NF-κB signal pathway DOI

Yawei Zhang,

Hengheng Zheng,

Baitong Li

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

Citations

0
Recent Advances in the Mutual Regulation of m6A Modification and Non-Coding RNAs in Atherosclerosis DOI Creative Commons

Yanlu Wang,

Shun M. Ling,

Hao Feng

et al.

International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 1047 - 1073

Published: Feb. 1, 2025

Atherosclerosis, a progressive inflammatory disease of the arteries, remains leading cause cardiovascular morbidity and mortality worldwide. Recent years have witnessed pivotal role N6-methyladenosine (m6A) RNA methylation in regulating various biological processes, including those implicated atherosclerosis. Current evidence suggested that m6A regulators (writers, erasers, readers) participated modification multiple non-coding RNAs (ncRNAs), microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), thereby affecting their metabolism functions. Meanwhile, ncRNAs also emerged as key modulator expression turn. Therefore, understanding mutual regulation between modifications is great significance to identify novel therapeutic targets for atherosclerosis has clinical application prospects. This review aims summarize recent advances reciprocal provide insights into interaction context

Language: Английский

Citations

0
Myeloid Differentiation Primary Response Protein 88: An Important Therapeutic Target for Chronic Pain DOI Creative Commons

H. Liang,

Linbin Fu, Zheng Li

et al.

Journal of Pain Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1061 - 1069

Published: March 1, 2025

Chronic pain is a major cause of suffering. This interferes with daily functioning and often accompanied by distress. However, current therapeutic strategies for chronic are unsatisfactory because poor understanding its mechanisms. Therefore, more comprehensive targets must be identified to improve the quality life these patients. Myeloid differentiation primary response protein 88 (MyD88) an adaptor toll-like receptor (TLR) interleukin-1 (IL-1R) families. Recently, overexpression MyD88 in spinal dorsal root ganglia was observed multiple models, which also revealed that plays important role development maintenance pain. In this review, we summarized roles mechanisms progression different including chemotherapy-induced peripheral neuropathy (CIPN), diabetic neuropathic (DNP), nerve ligation (SNL), constriction injury (CCI), cord (SCI) inflammatory

Language: Английский

Citations

0