Mitochondrial DNA leakage: underlying mechanisms and therapeutic implications in neurological disorders

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 7, 2025

Mitochondrial dysfunction is a pivotal instigator of neuroinflammation, with mitochondrial DNA (mtDNA) leakage as critical intermediary. This review delineates the intricate pathways leading to mtDNA release, which include membrane permeabilization, vesicular trafficking, disruption homeostatic regulation, and abnormalities in dynamics. The escaped activates cytosolic sensors, especially cyclic gmp-amp synthase (cGAS) signalling inflammasome, initiating neuroinflammatory cascades via pathways, exacerbating spectrum neurological pathologies. therapeutic promise targeting discussed detail, underscoring necessity for multifaceted strategy that encompasses preservation homeostasis, prevention leakage, reestablishment dynamics, inhibition activation sensors. Advancing our understanding complex interplay between neuroinflammation imperative developing precision interventions disorders.

Language: Английский

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Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 12, 2025

Peroxisome proliferator-activated receptor- γ coactivator-1α (PGC-1α), which is highly expressed in the central nervous system, known to be involved regulation of mitochondrial biosynthesis, metabolic regulation, neuroinflammation, autophagy, and oxidative stress. This knowledge indicates a potential role PGC-1α wide range functions associated with neurological diseases. There emerging evidence indicating protective pathogenesis several As such, deeper broader understanding its diseases urgently needed. The present review provides relatively complete overview current on PGC-1α, including different types neurons, basic structural characteristics, interacting transcription factors. Furthermore, we various diseases, such as intracerebral hemorrhage, ischemic stroke, Alzheimer’s disease, Parkinson’s Amyotrophic lateral sclerosis, Huntington’s other PolyQ Importantly, discuss some compounds or drug-targeting strategies that have been studied ameliorate pathology these introduce possible mechanistic pathways. Based available studies, propose targeting could serve promising novel therapeutic strategy for one more

Language: Английский

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Mitochondrial dysfunction as a therapeutic strategy for neurodegenerative diseases: Current Insights and Future Directions

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102577 - 102577

Published: Nov. 10, 2024

Language: Английский

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Parkinson’s disease models and death signaling: what do we know until now?

Frontiers in Neuroanatomy, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 29, 2024

Parkinson's disease (PD) is the second neurodegenerative disorder most prevalent in world, characterized by loss of dopaminergic neurons Substantia Nigra (SN). It well known for its motor and non-motor symptoms including bradykinesia, resting tremor, psychiatric, cardiorespiratory, other dysfunctions. Pathological apoptosis contributes to a wide variety diseases PD. Various insults and/or cellular phenotypes have been shown trigger distinct signaling events leading cell death affected The intrinsic or mitochondrial pathway, inflammatory oxidative stress-induced extrinsic pathways are main associated with PD-related neuronal loss. Although SN brain area studied so far, nuclei also non-classical as symptoms. Among these, respiratory often overlooked, yet they can cause discomfort may contribute patients shortened lifespan after diagnosis. While animal

Language: Английский

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