Zingiber officinale-derived exosome-like nanoparticles as antimicrobial agents via lipid-mediated inhibition DOI Creative Commons

C.-G. Zhu,

Bihu Gao,

Jiao Li

et al.

Nano Express, Journal Year: 2024, Volume and Issue: 5(4), P. 045009 - 045009

Published: Nov. 14, 2024

Abstract Microbial diseases represent a significant challenge to global health, highlighting the importance of developing novel alternative antibacterial agents. The widely used spice and traditional medicinal plant Zingiber officinale its derivatives have been demonstrated possess promising properties. aim present study was assess efficacy -derived exosome-like nanoparticles (ZODENs) against model bacterium, Escherichia coli ( E. ). ZODENs were isolated from rhizome subjected morphological, size distribution, zeta potential characterization. bacterial growth curve assays colony formation that remarkably inhibited following incubation with ZODENs. observed be internalized by bacteria incubation, subsequently remarkable killing effects. Furthermore, ZODEN-derived lipids, rather than remaining fractions, capacity inhibit cells, indicating activity at least partially attributable lipid content. These findings paved way for development ZODEN-based agents will facilitate future clinical translation plant-derived nanomedicines.

Language: Английский

Advances of transdermal drug delivery system based on extracellular vesicles DOI

Haoqiang Qin,

Min Zhang, Hao Wang

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106647 - 106647

Published: Jan. 1, 2025

Language: Английский

Citations

0
Advances in Plant-Derived Extracellular Vesicle Extraction Methods and Pharmacological Effects DOI Creative Commons

Nuerbiye Nueraihemaiti,

Dilihuma Dilimulati,

Alhar Baishan

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 377 - 377

Published: April 6, 2025

Extracellular vesicles (EVs) are those with a double-membrane structure that contains proteins, lipids, nucleic acids, and other biologically active substances play an important role in cell–cell cell–environment communication. They have also become mechanism for exchanging cellular molecules. As many studies on EVs been conducted, plant-derived extracellular (PDEVs) started attracting attention. The biological activity stability of PDEVs closely related to the extraction separation methods, choosing method meets requirements is important. methods include ultracentrifugation, ultrafiltration, size-exclusion chromatography, etc. In recent years, it has found through research possess properties, such as anti-inflammatory, anti-cancer, anti-infective they show unique advantages therapeutic agents drug carriers. Therefore, we collected scientific literature derived from more than dozen fruits vegetables, summarized analyzed their extraction, separation, roles disease treatment, aiming provide reference inspiration in-depth study efficacy new drugs.

Language: Английский

Citations

0
Pasteurization and lyophilization affect membrane proteins of pomegranate-derived nanovesicles reducing their functional properties and cellular uptake DOI
Mari Cruz Manzaneque-López, Aránzazu González, Pedro Pérez‐Bermúdez

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144303 - 144303

Published: April 1, 2025

Language: Английский

Citations

0
Anti-inflammatory and antioxidative effects of Perilla frutescens-derived extracellular vesicles: Insights from Zebrafish models DOI

Jinghong Huang,

Linxin Chen, Wenhua Li

et al.

Molecular Immunology, Journal Year: 2025, Volume and Issue: 182, P. 126 - 138

Published: April 22, 2025

Language: Английский

Citations

0
Sirtuins as Players in the Signal Transduction of Citrus Flavonoids DOI Open Access
Giovanni Enrico Lombardo, Caterina Russo, Alessandro Maugeri

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 1956 - 1956

Published: Feb. 6, 2024

Sirtuins (SIRTs) belong to the family of nicotine adenine dinucleotide (NAD+)-dependent class III histone deacetylases, which come into play in regulation epigenetic processes through deacetylation histones and other substrates. The human genome encodes for seven homologs (SIRT1-7), are localized nucleus, cytoplasm, mitochondria, with different enzymatic activities regulatory mechanisms. Indeed, SIRTs involved physio-pathological responsible onset several illnesses, such as cardiovascular neurodegenerative diseases, obesity diabetes, age-related disorders, cancer. Nowadays, it is well-known that Citrus fruits, typical Mediterranean diet, an important source bioactive compounds, polyphenols. Among these, flavonoids recognized potential agents endowed a wide range beneficial properties, including antioxidant, anti-inflammatory, hypolipidemic, antitumoral ones. On these bases, we offer comprehensive overview on biological effects exerted by via targeting SIRTs, acted modulator signaling pathways. According reported studies, appear be promising SIRT modulators many pathologies, role might potentially evaluated future therapies, along encouraging study those members still lack proper evidence their support.

Language: Английский

Citations

3
Oral administration of cranberry-derived exosomes attenuates murine premature ovarian failure in association with changes in the specific gut microbiota and diminution in ovarian granulosa cell PANoptosis DOI Creative Commons

Zeyu Cui,

Te Liu,

Yichao Wen

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(23), P. 11697 - 11714

Published: Jan. 1, 2024

We confirmed that oral administration of cranberry-derived exosomes attenuated murine POF by modulating the gut microbiota and decreasing ovarian granulosa cell PANoptosis.

Language: Английский

Citations

2
Engineering Strategies of Plant-Derived Exosome-Like Nanovesicles: Current Knowledge and Future Perspectives DOI Creative Commons
Yuhan Li, Yulong Wang,

Hongrui Zhao

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12793 - 12815

Published: Nov. 1, 2024

Plant-derived exosome-like nanovesicles (PELNs) from edible plants, isolated by ultracentrifugation, size exclusion chromatography or other methods, were proved to contain a variety of biologically active and therapeutically specific components. Recently, investigations in the field PELN-based biomedicine have been conducted, which positioned those as promising tools for prevention treatment several diseases, with their natural origin potentially offering superior biocompatibility bioavailability. However, inadequate targeting limited therapeutic effects constrain utility clinical translation PELNs. Thus, strategies aiming at bridging gap engineering PELNs great interest. Those approaches include membrane hybridization, physical chemical surface functionalization encapsulation payloads. Herein, we provide comprehensive overview biogenesis composition, isolation purification methods characterization PELNs, well functions. Current knowledge on construction biomedical application engineered reviewed. Additionally, future directions perspectives this discussed order further enrich expand prospects

Language: Английский

Citations

2
Lipidomic analysis of plant-derived extracellular vesicles for guidance of potential anti-cancer therapy DOI
Fei Wang,

Lanya Li,

Junyao Deng

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 46, P. 82 - 96

Published: Dec. 10, 2024

Language: Английский

Citations

2
Paenibacillus exopolysaccharide repairs GI inflammation by suppressing MAPK and NF-κB and restoring lipid production in Caco-2 cell line DOI Creative Commons
Jing Zhang,

LI Zhi-qiang,

Ru-Jing Zheng

et al.

Journal of Functional Foods, Journal Year: 2023, Volume and Issue: 107, P. 105709 - 105709

Published: July 29, 2023

Paenibacillus polymyxa exopolysaccharide PYQ1-EPS is a homogeneous glucomannan-type polysaccharide. In this work, its stability and reparative effects on the in vitro model of inflammatory bowel disease (IBD) possible mechanisms were investigated to expand application fields. The results showed that significantly increased cell viability, inhibited expression pro-inflammatory cytokines promoted anti-inflammatory cytokines, which effectively blocked activation NF-κB MAPK signaling pathways. Meanwhile, it was found effect closely related lipid metabolism cells, restored content inflammation cells 90.7% untreated cells. This first report bacterial polysaccharides inhibit gastrointestinal by modulating metabolism. Upon understanding functional mechanisms, our work demonstrated has great potential be developed as food for protection.

Language: Английский

Citations

4
Mitigation of Oxidative Stress in Idiopathic Pulmonary Fibrosis Through Exosome-Mediated Therapies DOI Creative Commons

Zaiyan Wang,

Yuan Zhang,

Xiaoning Li

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 6161 - 6176

Published: June 1, 2024

Abstract: Idiopathic pulmonary fibrosis (IPF) poses a formidable clinical challenge, characterized by the thickening of alveolar septa and onset fibrosis. The pronounced activation oxidative stress emerges as pivotal hallmark inflammation. Traditional application exogenous antioxidants proves inadequate in addressing stress, necessitating exploration into strategies to augment their antioxidant efficacy. Exosomes, nano-sized extracellular vesicles harboring diverse array bioactive factors, present promising carriers with potential meet this challenge. Recent attention has been directed towards applications exosomes IPF, fueling impetus for comprehensive review. We have compiled fresh insights role modulating IPF delved regulating endogenous reactive oxygen species generation. This review endeavors bridge divide between exosome research traversing from bedside bench. Through synthesis recent findings, we propose novel strategy improving outcomes therapy. Keywords: idiopathic fibrosis, exosomes, treatment

Language: Английский

Citations

1