Cross-sectional and longitudinal changes in category-selectivity in visual cortex following pediatric cortical resection DOI Creative Commons
Tina T. Liu, Michael C. Granovetter, Anne Margarette S. Maallo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract The topographic organization of category-selective responses in human ventral occipitotemporal cortex (VOTC) and its relationship to regions subserving language functions is remarkably uniform across individuals. This arrangement thought result from the clustering neurons responding similar inputs, constrained by intrinsic architecture tuned experience. We examined malleability this individuals with unilateral resection VOTC during childhood for management drug-resistant epilepsy. In cross-sectional longitudinal functional imaging studies, we compared topography neural representations 17 a resection, ‘control patient’ outside VOTC, typically developing matched controls. demonstrated both adherence deviation standard uncovered fine-grained competitive dynamics between word- face-selectivity over time single, preserved VOTC. findings elucidate nature extent cortical plasticity highlight potential remodeling extrastriate function. Teaser After pediatric deviations constraints visual reflect plasticity.

Language: Английский

Origins of food selectivity in human visual cortex DOI
Margaret Henderson, Michael J. Tarr, Leila Wehbe

et al.

Trends in Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Individual variation in the functional lateralization of human ventral temporal cortex: Local competition and long-range coupling DOI Creative Commons
Nicholas M. Blauch, David C. Plaut, Raina Vin

et al.

Imaging Neuroscience, Journal Year: 2025, Volume and Issue: 3

Published: Jan. 1, 2025

The ventral temporal cortex (VTC) of the human cerebrum is critically engaged in high-level vision. One intriguing aspect this region its functional lateralization, with neural responses to words being stronger left hemisphere, and faces right hemisphere; such patterns can be summarized a signed laterality index (LI), positive for leftward laterality. Converging evidence has suggested that word emerges couple efficiently left-lateralized frontotemporal language regions, but more mixed regarding sources lateralization face perception. Here, we use individual differences as tool test three theories VTC organization arising from (1) local competition between driven by long-range coupling processes, (2) other categories, (3) areas exhibiting social processing. First, an in-house MRI experiment, did not obtain negative correlation LIs selectivity relative object responses, find when using fixation baseline, challenging ideas driving rightward lateralization. We next examined broader LI interactions large-scale Human Connectome Project (HCP) dataset. Face were significantly anti-correlated, while body positively correlated, consistent idea generic representational cooperation may shape Last, assessed role development Within our substantial was evident text several nodes distributed text-processing circuit. In HCP data, both negatively correlated processing different subregions posterior lobe (PSL STSp, respectively). summary, no face-word VTC; instead, multiple lateralities within VTC, including Moreover, also influenced lobe, where become lateralized due language.

Language: Английский

Citations

0
The ‘reading’ brain: Meta-analytic insight into functional activation during reading in adults DOI Creative Commons
Sabrina Turker,

Beatrice Fumagalli,

Philipp Kuhnke

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106166 - 106166

Published: April 1, 2025

Literacy provides the key to social contacts, education, and employment, significantly influences well-being mental health. Summarizing 163 studies, present coordinate-based meta-analysis confirms importance of classical left-hemispheric language regions cerebellum across reading tasks. We found high processing specificity for letter, word, sentence, text exclusively in areas. Subregions within left inferior frontal gyrus showed differential engagement word pseudoword reading, while subregions temporo-occipital cortex words sentences. The direct comparison overt covert revealed higher activation likelihood auditory motor during first, more consistent reliance on multiple demand latter. Last, silent (explicit reading) yielded orbito-frontal, cerebellar temporal cortices when compared lexical decisions (implicit reading). Lexical decisions, contrast, bilateral recruitment insular regions. extends our understanding neural architecture underlying processes, corroborates findings from neurostimulation studies can provide valuable insight into models.

Language: Английский

Citations

0
Individual variation in the functional lateralization of human ventral temporal cortex: Local competition and long-range coupling DOI Creative Commons
Nicholas M. Blauch, David C. Plaut, Raina Vin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract The ventral temporal cortex (VTC) of the human cerebrum is critically engaged in computations related to high-level vision. One intriguing aspect this region its asymmetric organization and functional lateralization. Notably, VTC, neural responses words are stronger left hemisphere, whereas faces right hemisphere. Converging evidence has suggested that left-lateralized word emerge couple efficiently with frontotemporal language regions, but more mixed regarding sources right-lateralization for face perception. Here, we use individual differences as a tool adjudicate between three theories VTC arising from: 1) local competition faces, 2) other categories, 3) long-range coupling areas subject their own competition. First, an in-house MRI experiment, demonstrated laterality both substantial reliable within right-handed population young adults. We found no (anti-)correlation selectivity relative object responses, positive correlation when using fixation baseline, challenging ideas faces. next examined broader large-scale Human Connectome Project (HCP) dataset. Face were significantly anti-correlated, while body positively correlated, consistent idea generic representational cooperation may shape Last, assessed role development laterality. Within our was evident text several nodes distributed text-processing circuit. In HCP data, negatively correlated laterality, social perception same areas, effect processing representations, driven by processing. conclude interactions heterogeneous hemispheric specializations visual cortex.

Language: Английский

Citations

2
Demystifying the Visual Word Form Area: Visual and Nonvisual Response Properties of Ventral Temporal Cortex with precision fMRI DOI Creative Commons
Jin Li, Kelly J. Hiersche,

Zeynep M. Saygin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 15, 2023

Summary The functional nature of the visual word form area (VWFA), a region in left ventrotemporal cortex (VTC), remains debated after over two decades investigation. Here we use precision fMRI to comprehensively examine VWFA’s responses numerous and nonvisual stimuli. We find that VWFA is distinct while showing moderate activation non-word stimuli, its response words towers above other conditions. Interestingly, also only VTC uniquely engaged auditory language processing, contrast with ubiquitous attentional effect within VTC. However, this selectivity dwarfed by responses. This suggests primarily functions as look-up orthographic dictionary. Searching entire further reveals an additional cluster anterior fusiform preferring general semantics. Our detailed examination direct comparison regions clarifies long-standing controversies about functionality.

Language: Английский

Citations

4
Music literacy shapes the specialization of a right hemispheric word reading area DOI Creative Commons
Alice Mado Proverbio,

Elham Sanoubari

Neuroimage Reports, Journal Year: 2024, Volume and Issue: 4(4), P. 100219 - 100219

Published: Sept. 25, 2024

Language: Английский

Citations

0
Demystifying Visual Word Form Area Visual and Nonvisual Response Properties with Precision fMRI DOI Creative Commons
Jin Li, Kelly J. Hiersche,

Zeynep M. Saygin

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(12), P. 111481 - 111481

Published: Nov. 26, 2024

Language: Английский

Citations

0
Cross-sectional and longitudinal changes in category-selectivity in visual cortex following pediatric cortical resection DOI Creative Commons
Tina T. Liu, Michael C. Granovetter, Anne Margarette S. Maallo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract The topographic organization of category-selective responses in human ventral occipitotemporal cortex (VOTC) and its relationship to regions subserving language functions is remarkably uniform across individuals. This arrangement thought result from the clustering neurons responding similar inputs, constrained by intrinsic architecture tuned experience. We examined malleability this individuals with unilateral resection VOTC during childhood for management drug-resistant epilepsy. In cross-sectional longitudinal functional imaging studies, we compared topography neural representations 17 a resection, ‘control patient’ outside VOTC, typically developing matched controls. demonstrated both adherence deviation standard uncovered fine-grained competitive dynamics between word- face-selectivity over time single, preserved VOTC. findings elucidate nature extent cortical plasticity highlight potential remodeling extrastriate function. Teaser After pediatric deviations constraints visual reflect plasticity.

Language: Английский

Citations

0