Mast cell–derived chymases are essential for the resolution of inflammatory pain in mice DOI
Sabrina de Souza,

Sophie Laumet,

Hannah Hua

et al.

Pain, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Immune cells play a critical role in the transition from acute to chronic pain. However, of mast pain remains underinvestigated. Here, we demonstrated that resolution inflammatory is markedly delayed cell–deficient mice. In response complete Freund adjuvant, mice showed greater levels nitric oxide, leukocyte infiltration, and altered cytokine/chemokine profile inflamed skin both sexes. wild-type mice, number cell cell–derived chymases, chymase 1 (CMA1) protease 4 (MCPT4), increased skin. Inhibiting enzymatic activity Consistently, local pharmacological administration recombinant CMA1 MCPT4 promoted hypersensitivity attenuated upregulation cytokines chemokines under inflammation. We identified CCL9 as target MCPT4. Inhibition recruitment CD206 + myeloid alleviated Our work reveals new chymases preventing suggests therapeutic avenues for treatment

Language: Английский

Inflammatory Processes Affecting Bone Health and Repair DOI
Haydée Torres de Oliveira, Katherine M. Arnold,

Manuela Oviedo

et al.

Current Osteoporosis Reports, Journal Year: 2023, Volume and Issue: 21(6), P. 842 - 853

Published: Sept. 28, 2023

Language: Английский

Citations

25
Compartment-specific regulation of NaV1.7 in sensory neurons after acute exposure to TNF-α DOI Creative Commons
Sidharth Tyagi, Grant P. Higerd‐Rusli, Mohammad‐Reza Ghovanloo

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(2), P. 113685 - 113685

Published: Jan. 22, 2024

Tumor necrosis factor α (TNF-α) is a major pro-inflammatory cytokine, important in many diseases, that sensitizes nociceptors through its action on variety of ion channels, including voltage-gated sodium (Na

Language: Английский

Citations

14
The cytokines in tumor microenvironment: from cancer initiation-elongation-progression to metastatic outgrowth DOI
Rajalaxmi Pradhan,

Anushka Kundu,

Chanakya Nath Kundu

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 196, P. 104311 - 104311

Published: March 3, 2024

Language: Английский

Citations

11
Neurogenic inflammation and itch in barrier tissues DOI
Rebecca Liu,

Dean R Buttaci,

Caroline L. Sokol

et al.

Seminars in Immunology, Journal Year: 2025, Volume and Issue: 77, P. 101928 - 101928

Published: Jan. 10, 2025

Language: Английский

Citations

1
Mast cell–derived chymases are essential for the resolution of inflammatory pain in mice DOI
Sabrina de Souza,

Sophie Laumet,

Hannah Hua

et al.

Pain, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Immune cells play a critical role in the transition from acute to chronic pain. However, of mast pain remains underinvestigated. Here, we demonstrated that resolution inflammatory is markedly delayed cell–deficient mice. In response complete Freund adjuvant, mice showed greater levels nitric oxide, leukocyte infiltration, and altered cytokine/chemokine profile inflamed skin both sexes. wild-type mice, number cell cell–derived chymases, chymase 1 (CMA1) protease 4 (MCPT4), increased skin. Inhibiting enzymatic activity Consistently, local pharmacological administration recombinant CMA1 MCPT4 promoted hypersensitivity attenuated upregulation cytokines chemokines under inflammation. We identified CCL9 as target MCPT4. Inhibition recruitment CD206 + myeloid alleviated Our work reveals new chymases preventing suggests therapeutic avenues for treatment

Language: Английский

Citations

1