Personalized Intervention Based on Early Detection of Atherosclerosis

Journal of the American College of Cardiology, Journal Year: 2024, Volume and Issue: 83(21), P. 2112 - 2127

Published: May 1, 2024

Language: Английский

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Advancements in risk stratification and management strategies in primary cardiovascular prevention

Atherosclerosis, Journal Year: 2024, Volume and Issue: 395, P. 117579 - 117579

Published: May 15, 2024

Language: Английский

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Advances in targeting LDL cholesterol: PCSK9 inhibitors and beyond

American Journal of Preventive Cardiology, Journal Year: 2024, Volume and Issue: 19, P. 100701 - 100701

Published: June 25, 2024

There is a direct relationship between the duration and level of exposure to low density lipoprotein cholesterol (LDL-C) levels over one's lifespan cardiovascular events. Early treatment lower elevated LDL-C crucial for better outcomes with multiple therapies currently available reduce atherogenic lipoproteins. Statins remain foundation lowering therapy as one most cost-effective drugs atherosclerotic events (ASCVD) mortality. Nonetheless, LDL-driven goal attainment remains suboptimal globally, highlighting considerable need non-statin address residual risk related statin intolerance, non-adherence, inherited disorders. interventions beyond statins include ezetimibe, PCSK9 monoclonal antibodies, inclisiran bempedoic acid specific guideline recommendations when consider each. For patients homozygous familial hypercholesterolemia requiring more advanced therapy, lomitapide evinacumab are available, providing mechanisms that not LDL receptor dependent. Lipoprotein apheresis an effective option clinical well (a). investigational being explored add our current armamentarium including CETP inhibitors, third-generation inhibitor (small recombinant fusion protein oral inhibitor) gene editing which aims directly restore or disrupt genes interest at DNA level. This article brief review pharmacotherapy options their impact on ASCVD reduction. Our primary aim guide physicians role these play in achieving appropriate goals, algorithm each based efficacy, safety outcomes.

Language: Английский

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Nurses' experiences of competence in lifestyle counselling with adult patients in healthcare settings: A qualitative systematic literature review

Journal of Clinical Nursing, Journal Year: 2024, Volume and Issue: 33(5), P. 1684 - 1708

Published: Feb. 8, 2024

To identify and synthesise nurses' experiences of competence in lifestyle counselling with adult patients healthcare settings.

Language: Английский

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2-Fold More Cardiovascular Disease Events Decades Before Type 2 Diabetes Diagnosis

Journal of the American College of Cardiology, Journal Year: 2024, Volume and Issue: 84(23), P. 2251 - 2259

Published: Nov. 25, 2024

Language: Английский

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Measuring the Impact of Obesity on Cardiovascular Risk for Northern Colorado School Children: Healthy Hearts and Minds Program 2013-2023

American Journal of Preventive Cardiology, Journal Year: 2025, Volume and Issue: 21, P. 100933 - 100933

Published: Jan. 25, 2025

Language: Английский

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Which Parameter Related to Low-Density Lipoprotein Cholesterol is Superior for Predicting the Recurrence of Myocardial Infarction in Young Patients with Previous Coronary Heart Disease? A Real-World Study

Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 20, 2025

Background: Lowering low-density lipoprotein cholesterol (LDL-C) is a well-established strategy for the secondary prevention of coronary heart disease (CHD). However, effectiveness specific LDL-C parameters in predicting myocardial infarction (MI) recurrence real-world settings remains inadequately explored. This study aims to examine relationship between MI and various young CHD patients. Methods: retrospective cohort involved 1013 patients aged 18–44 at time initial diagnosis, collected from cardiology department clinics Beijing Anzhen Hospital October 2022 2023. levels were assessed diagnosis final follow-up. The primary outcome was events, analyzed using survival analysis logistic regression models determine associations with parameters. Results: included (mean age: 38.5 ± 3.9 years; 94.7% men), median follow-up 1.7 years. Initially, 13.6% had <1.8 mmol/L, which increased 37.8% by study’s end. During follow-up, 96 (9.5%) experienced MI. While mmol/L baseline showed slightly lower cumulative incidence than ≥1.8 difference not statistically significant (log-rank p = 0.335). Reductions ≥50% patterns change did correlate decreased risk. <1.4 measurement associated reduced risk (adjusted odds ratio [OR]: 0.57, 95% confidence interval [CI]: 0.33–0.98) compared ≥2.6 mmol/L. Conclusions: suggests that most important parameter related history ideal target level. could potentially reduce risk, regardless levels.

Language: Английский

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Bioinformatics Approach to Investigating the Immuno-Inflammatory Mechanisms of Periodontitis in the Progression of Atherosclerosis

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 197 - 197

Published: March 17, 2025

Unstable atherosclerotic plaques are a major cause of acute cardiovascular events and ischemic stroke. Clinical studies have suggested link between periodontitis plaque progression, but the underlying mechanisms remain unclear. To investigate this, transcriptomic datasets related to atherosclerosis were downloaded from Gene Expression Omnibus. A weighted gene co-expression network analysis was used identify modules associated with periodontitis, Limma R package identified differentially expressed genes (DEGs) unstable stable plaques. Overlapping defined as periodontitis-related DEGs, followed by functional enrichment protein–protein interaction construction. Machine learning methods biomarkers for which validated using external datasets. Immune infiltration single-cell analyses performed explore relationship immune cells. total 161 DEGs identified, pathway showing associations regulation collagen matrix degradation. HCK, NCKAP1L, WAS plaques, demonstrating high diagnostic value (AUC: 0.9884, 95% CI: 0.9641–1). revealed an increase in macrophages within Single-cell showed HCK expression dendritic cells, while NCKAP1L macrophages, NK T Consensus clustering three patterns Our findings mouse models periodontitis. This study provides insights into how contributes instability, supporting diagnosis intervention patients

Language: Английский

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Ethanol extract of Portulaca oleracea L. mitigates atherosclerosis through modulation of cholesterol efflux and uptake pathways

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 19, 2025

Background Purslane ( Portulaca oleracea ) is a medicinal and edible plant. extract (POEE) exhibits lipid-lowering, anti-inflammatory, antioxidant properties. Traditionally, this has been used to treat various inflammatory conditions, including skin inflammation, enteritis, dysentery. However, its therapeutic potential molecular mechanisms in atherosclerosis (AS) remain unclear. Methods Ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (UPLC-Q/TOF-MS) the Traditional Chinese Medicine Systems Pharmacology Database were employed identify active components of POEE. Network pharmacology was predict POEE’s for alleviating AS. An vitro foam cell model established by treating RAW264.7 macrophages with oxidized low-density lipoprotein (ox-LDL), protective effects POEE assessed via 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay, while intracellular lipid accumulation identified using Oil Red O staining. Protein expression related cholesterol metabolism analyzed Western blot (WB). For vivo validation, AS induced rats through high-fat diet carotid artery injury. After 4 weeks daily administration, efficacy tested measuring serum levels, cardiac function, histopathological changes, transport-related protein expression. Results The bioactive compounds categorized into 10 groups, flavonoids (24), terpenoids (16), phenols (6), alkaloids (4), others. predictions implicated modulating “Lipid Atherosclerosis” pathway. significantly reduced total (TC) free (FC) levels ox-LDL-stimulated macrophages, attenuating formation. Furthermore, enhanced reverse transport (RCT) upregulating expressions ATP-binding cassette transporters ABCA1 ABCG1 promote efflux, suppressing CD36 MSR1 inhibit uptake. In , administration lowered triglycerides (TG), TC, FC, LDL-C levels; elevated HDL-C; ameliorated lesions rats. Concordantly, upregulated that downregulated POEE-treated tissues. Conclusion alleviates enhancing RCT regulation efflux uptake pathways. may be promising candidate

Language: Английский

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A high-sensitivity label-free electrochemical aptasensor for point-of-care measurements of low-density lipoprotein in plasma based on aptamer and MXene-CMCS-Hemin nanocomposites

Bioelectrochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108972 - 108972

Published: March 1, 2025

Language: Английский

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