Nitric Oxide, Journal Year: 2024, Volume and Issue: 152, P. 78 - 89
Published: Sept. 19, 2024
Language: Английский
JACC Advances, Journal Year: 2025, Volume and Issue: 4(4), P. 101676 - 101676
Published: March 22, 2025
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: April 17, 2025
The ratio of non-high-density lipoprotein cholesterol to high-density (NHHR) has been introduced as a novel indicator evaluate lipid metabolism. study explored the association between NHHR and cardiovascular disease (CVD). A cross-sectional was achieved by utilizing data obtained from NHANES (2003-2016). CVD assessed multivariate logistic regression analysis (LRA) restricted cubic spline (RCS) analysis. Also, interaction tests subgroup analyses were employed explore whether associations differ subgroups. Then, threshold conducted for interval delineation detection effects with two-segment piecewise LR model. cohort 11,471 individuals involved. results indicated that linear relationship not significant (P trend >0.05). RCS revealed non-linear J-shaped risk. model established assess effect NHHR. log-likelihood test < 0.001) suggested exhibited better performances compared single-line Additionally, tangent point occurred at 2.82, likelihood increased 21% one unit (OR = 1.21, 95% CI 1.10-1.34). detected prevalence CVD, suggesting could serve assessment marker identifying high-risk populations. However, further studies are needed confirm this finding.
Language: Английский
Citations
0
Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Atherosclerosis (AS), a major cause of cardiovascular diseases, is characterized by lipid accumulation and chronic inflammation within arterial walls. Traditional treatments, such as statins, are often ineffective for many patients, highlighting the need novel therapeutic strategies. This study explores potential Resibufogenin (RBG) an NLRP3 inflammasome inhibitor treating AS in ApoE-/- mice. We performed experiments encompassing cellular studies, animal model assessments, molecular simulations, binding assays to assess RBG's impact on inflammasome, inflammatory cytokine release, foam cell formation. RBG treatment alleviated mice, evidenced reduced body weight, smaller atherosclerotic plaques, improved serum profiles. Transcriptomics biology demonstrated that suppressed expression key markers NLRP3. also macrophage infiltration promoted polarization toward anti-inflammatory M2 phenotype. Molecular docking, SPR, Pull-down studies identified non-covalent interaction between CYS-279 residue NLRP3, confirming its role potent inhibitor. effectively inhibits activation, reduces pro-inflammatory decreases formation foamy macrophages, thereby slowing progression AS. Although these findings highlight promising approach further research necessary safety effectiveness humans investigate possible synergistic effects with other treatments.
Language: Английский
Citations
0
Lifestyle Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 75 - 102
Published: Jan. 1, 2025
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Radiology, Journal Year: 2025, Volume and Issue: 315(1)
Published: April 1, 2025
A deep learning model enabled automated CT myocardial blood flow quantification and accurate evaluation of ischemic volume, which was an independent predictor for major adverse cardiovascular events mildly improved risk stratification.
Language: Английский
Citations
0
Metabolic Syndrome and Related Disorders, Journal Year: 2024, Volume and Issue: 22(5), P. 365 - 371
Published: Feb. 29, 2024
Background: Elevated homocysteine (Hcy) was considered a significant risk factor in the development and progression of carotid atherosclerosis (CAS), which involves combination inflammatory noninflammatory mechanisms. However, epidemiological surveys have presented conflicting results. In this study, we aim to offer an viewpoint on how elevated Hcy impacts CAS its potential
Language: Английский
Citations
2
Atherosclerosis, Journal Year: 2024, Volume and Issue: unknown, P. 117561 - 117561
Published: April 1, 2024
Citations
2
Current Problems in Cardiology, Journal Year: 2024, Volume and Issue: 49(7), P. 102637 - 102637
Published: May 10, 2024
Language: Английский
Citations
2
Canadian Journal of Cardiology, Journal Year: 2024, Volume and Issue: 40(8), P. S43 - S52
Published: Aug. 1, 2024
This article discusses the complex approach to managing atherosclerotic cardiovascular disease (ASCVD), focusing on person-centred care (PCC) align treatment strategies with individual patient narratives, values, and preferences. It identifies significant challenges in management of ASCVD, such as necessity for multidisciplinary need enhanced care, particularly given coexistence ASCVD other cardiometabolic risk factors. The paper points out existing practice gaps, including limited patient-provider information sharing decision making, considers role technology personalizing improving outcomes. Strategies electronic health records, telehealth platforms, motivational interviewing are examined their potential boost engagement adherence treatment. In addition, systemic issues provider burnout importance creating customized plans patients multiple conditions. integration varied approaches, involvement community pharmacists coaches, is suggested important effective ASCVD. review highlights an innovative, holistic strategy advocates a transformative shift toward PCC that integrates individual, community, system-level interventions enhance engagement, therapy adherence, overall
Language: Английский
Citations
2