Clinical Evaluation of a Trypsin Hydrolysate of Tenebrio molitor Larva (Meal Worm) on Feline Dermatitis DOI
Nishala Erandi Wedamulla, Young‐Jin Choi, Qun Zhang

et al.

Food Supplements and Biomaterials for Health, Journal Year: 2023, Volume and Issue: 3(4)

Published: Jan. 1, 2023

Language: Английский

Genetic and Immunological Pathogenesis of Atopic Dermatitis DOI
Charles F. Schuler, Lam C. Tsoi, Allison C. Billi

et al.

Journal of Investigative Dermatology, Journal Year: 2023, Volume and Issue: 144(5), P. 954 - 968

Published: Dec. 11, 2023

Language: Английский

Citations

18
Emerging Systemic Treatment Options in Atopic Dermatitis DOI Creative Commons
Andaç Salman, Ana M. Giménez‐Arnau

Balkan Medical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 239 - 247

Published: July 5, 2024

Atopic dermatitis (AD) is a chronic inflammatory condition that significantly affects the quality of life both patients and their families or caregivers. Recently, treatment for moderate-to-severe AD were limited to conventional immunosuppressive therapies. However, currently, with approval biologic treatments oral small molecules in past decade, effective safe management possible. Despite these advancements, challenges unmet needs clinical practice remain. This includes who do not respond well cannot tolerate existing options inadequate therapies can modify disease course. review aimed provide an overview current approach AD, highlight treatment, discuss rationale novel emerging evidence on systemic AD.

Language: Английский

Citations

4
Effectiveness of Nemolizumab in Improving Dialysis-Associated Pruritus Refractory to Difelikefalin: A Case Report DOI Open Access
Yoshihito Mima,

Masako Yamamoto,

Ken Iozumi

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Language: Английский

Citations

0
The Future of Atopic Dermatitis Treatment DOI
Katie Lovell, Nupur Patel,

Saroja Rao

et al.

Advances in experimental medicine and biology, Journal Year: 2024, Volume and Issue: unknown, P. 227 - 244

Published: Jan. 1, 2024

Language: Английский

Citations

3
Difelikefalin suppresses itch and reduces scratching independent of inflammation in a murine model of atopic dermatitis DOI Creative Commons
Masato Tamari,

Lydia Zamidar,

Aaron Ver Heul

et al.

Journal of Allergy and Clinical Immunology, Journal Year: 2023, Volume and Issue: 152(4), P. 927 - 932

Published: July 13, 2023

Therapies specifically targeting nonhistaminergic pruritus are largely lacking. Difelikefalin (DFK) has been found to reduce itch in various chronic pruritic conditions, including atopic dermatitis (AD).

Language: Английский

Citations

7
Abrocitinib may improve itch and quality of life in patients with itch‐dominant atopic dermatitis DOI Creative Commons
Jonathan I. Silverberg, Jacob P. Thyssen,

Irina Lazariciu

et al.

Skin Health and Disease, Journal Year: 2024, Volume and Issue: 4(4)

Published: May 5, 2024

Patients with atopic dermatitis (AD) exhibit heterogeneous clinical phenotypes, reflecting different combinations of itch and lesional severity. AD severe but clear-moderate lesions, also known as itch-dominant AD, is a common phenotype.

Language: Английский

Citations

1
Difelikefalin in the treatment of hemodialysis patients with pruritus: a systematic review and meta-analysis DOI Creative Commons

Xiaoyue Cai,

Guiming Wu, Yan Lin

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 6, 2024

Background and Objective Uremic pruritus is a persistent condition that difficult to cure in patients with end-stage renal disease who are having regular dialysis. It highly prevalent, current therapies have limited effectiveness can cause significant adverse effects. Several trials provided evidence difelikefalin be an effective treatment for uremic pruritus, few side responses. However, it important note the available limited. This study collected published randomized controlled systematic review Meta-analysis, explore efficacy safety of treating provide evidence-based medical clinical treatment. Methods A literature search was conducted PubMed, EMBASE, Web Science, Cochrane Library Data from building libraries 6 January 2024. We extracted data eligible studies analyze hemodialysis pruritus. Results comprised 9 4,118 people. The meta-analysis demonstrated more than placebo Specifically, resulted greater improvement WI-NRS scores at least 3 points baseline (OR = 1.98) 4 1.94). Additionally, led decrease total score 5-D itch scale (MD 1.56), skindex-10 4.92), 0.91). Conclusion Difelikefalin demonstrates alleviating individuals suffering uremia. Althogh has events, they mild.

Language: Английский

Citations

1
Emerging drugs for the treatment of atopic dermatitis: a focus on phase 2 and phase 3 trials DOI

Ogechi Obed,

Albert C. Chong,

Malcolm Su

et al.

Expert Opinion on Emerging Drugs, Journal Year: 2024, Volume and Issue: 29(3), P. 233 - 249

Published: April 25, 2024

Introduction Atopic dermatitis (AD) is an inflammatory skin condition that affects millions of pediatric and adult patients with well-studied impact on morbidity quality life. Management occurs in a stepwise fashion beginning preventative measures before immunomodulators are introduced. However, challenges remain treatment moderate to severe atopic refractory first second-line treatments there only few topical anti-inflammatory options, especially for patients.

Language: Английский

Citations

0
Adjunctive Management of Itch in Atopic Dermatitis DOI
Sarah G Brooks, Gil Yosipovitch

Dermatologic Clinics, Journal Year: 2024, Volume and Issue: 42(4), P. 577 - 589

Published: June 1, 2024

Language: Английский

Citations

0
Prurit et douleur cutanée au cours de la dermatite atopique DOI
L. Misery

Annales de Dermatologie et de Vénéréologie - FMC, Journal Year: 2024, Volume and Issue: 4(5), P. S27 - S34

Published: June 1, 2024

Citations

0