Anais Brasileiros de Dermatologia,
Journal Year:
2024,
Volume and Issue:
99(6), P. 895 - 915
Published: Aug. 12, 2024
Atopic
dermatitis
is
a
chronic,
recurrent,
and
multifactorial
skin-mucosal
manifestation
resulting
from
the
interaction
between
elements
mainly
associated
with
skin
barrier
deficit,
homeostasis
of
immune
response,
neurological
aspects,
patterns
reactivity
to
environmental
antigens,
which
are
established
in
genetically
predisposed
individuals.
In
addition
skin,
atopic
diathesis
involves
other
organs
such
as
airways
(upper
lower),
eyes,
digestive
tract,
neuropsychiatric
inflict
additional
morbidity
on
dermatological
patient.
The
different
phenotypes
disease
fundamentally
depend
participation
each
these
factors,
life
circumstances,
age
groups,
occupational
exposure
patterns,
physical
activity,
pollution,
genetic
load,
climatic
factors.
A
better
understanding
complexity
its
pathogenesis
allows
not
only
therapeutic
targets
but
also
how
identify
preponderant
that
mediate
activity
circumstance,
for
selecting
best
treatment
strategies
mitigation
triggering
This
narrative
review
presents
an
update
dermatitis,
especially
aimed
at
clinical
manifestations,
main
context
available
strategies.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(7), P. 2376 - 2376
Published: March 30, 2025
Off-label
treatment
is
the
use
of
a
drug
approved
for
marketing,
outside
registration
in
terms
indication,
age
group,
dose
or
route
administration.
Despite
constant
appearance
new
preparations
on
market,
SmPCs
guidelines
current
clinical
problem.
It
believed
that
it
based
needs
patients
unmet
by
classical
therapy
methods.
This
work
focuses
off-label
inflammatory
dermatoses
such
as
atopic
dermatitis,
psoriasis,
acne
vulgaris
and
rosacea.
Publications
this
subject,
available
PubMed,
Google
Scholar
Cochrane
Library,
were
analyzed
form
review,
taking
into
account
mechanisms
action,
efficacy
safety
preparations.
Based
literature
analysis,
can
be
concluded
drugs
SmPC
indications
common
situation
dermatology.
However,
difficult
to
determine
its
exact
frequency-there
lack
data
prevalence
appliances
from
European
perspective.
demonstrate
varying
effectiveness
therapy,
depending
specific
preparation.
dermatology
remains
an
important
issue
should
explored
further
research.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 1, 2025
Atopic
dermatitis
is
a
highly
heritable
and
common
inflammatory
skin
condition
affecting
children
adults
worldwide.
Multi-ancestry
approaches
to
atopic
genetic
association
studies
are
poised
boost
power
detect
signal
identify
loci
contributing
risk.
Here,
we
present
multi-ancestry
GWAS
meta-analysis
of
twelve
cohorts
from
five
ancestral
populations
totaling
56,146
cases
602,280
controls.
We
report
101
genomic
associated
with
dermatitis,
including
16
that
have
not
been
previously
or
eczema.
Fine-mapping,
QTL
colocalization,
cell-type
enrichment
analyses
identified
genes
cell
types
implicated
in
pathophysiology.
Functional
keratinocytes
provide
evidence
for
could
play
role
through
epidermal
barrier
function.
Our
study
provides
insights
into
the
etiology
by
harnessing
multiple
functional
unveil
mechanisms
which
dermatitis-associated
variants
impact
types.
condition.
authors
perform
carry
out
downstream
experiments
understand
they
identify.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(8), P. 3827 - 3827
Published: April 18, 2025
Extracellular
vesicles
(EVs),
including
exosomes,
microvesicles,
and
apoptotic
bodies,
are
released
into
the
extracellular
space
by
almost
all
known
cell
types.
They
facilitate
communication
between
cells
transferring
bioactive
molecules,
which
impact
both
physiological
processes
development
of
diseases.
EVs
play
a
crucial
role
in
pathogenesis
various
diseases
participating
multiple
pathological
processes.
contribute
to
disease
progression
triggering
cytokine
release,
modulating
immune
activity,
inducing
inflammatory
responses.
Beyond
their
implications,
also
offer
significant
therapeutic
potential.
Both
natural
engineered
show
great
potential
fields
targeted
therapy,
drug
delivery,
modulation
dermatological
applications.
The
EV-based
treatments
is
showing
promise
advancing
patient
outcomes,
particularly
chronic
immune-mediated
skin
conditions.
This
review
comprehensively
examined
biogenesis,
classification,
functional
roles
EVs,
advanced
methods
for
isolation
characterization.
Furthermore,
we
summarized
recent
studies
highlighting
involvement
four
major
diseases:
psoriasis,
atopic
dermatitis,
systemic
lupus
erythematosus,
wound
healing.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 28, 2025
Atopic
dermatitis
is
a
chronic
inflammatory
skin
condition
with
higher
incidence
rate
among
children.
In
recent
years,
the
role
of
gut
microbiota
in
pathogenesis
atopic
has
garnered
increasing
attention.
This
review
systematically
delineates
research
advancements
structural
characteristics
children
and
its
influencing
factors.
Studies
have
revealed
significant
differences
structure
between
healthy
controls,
characterized
by
reduction
microbial
diversity,
decrease
beneficial
bacteria,
an
increase
harmful
bacteria.
Dietary
patterns,
environmental
factors,
birth
antibiotic
use,
gestational
diabetes
mellitus
are
factors
could
impact
hence
susceptibility
to
dermatitis.
Moreover,
this
explores
interplay
immune
system
dermatitis,
potential
inform
more
effective
probiotic
treatment
strategies
for
