The (neuro)inflammatory system in anxiety disorders and PTSD: Potential treatment targets

Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108825 - 108825

Published: Feb. 1, 2025

Language: Английский

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Inflammation in Post-Traumatic Stress Disorder (PTSD): A Review of Potential Correlates of PTSD with a Neurological Perspective

Antioxidants, Journal Year: 2020, Volume and Issue: 9(2), P. 107 - 107

Published: Jan. 26, 2020

Post-traumatic stress disorder (PTSD) is a chronic condition characterized by symptoms of physiological and psychosocial burden. While growing research demonstrated signs inflammation in PTSD, specific biomarkers that may be representative PTSD such as the detailed neural correlates underlying inflammatory responses relation to trauma exposure are seldom discussed. Here, we review recent studies explored alterations key markers well neuroimaging-based further investigated within brain provide comprehensive summary literature with neurological perspective. A search was conducted on published from 2009 through 2019 PubMed Web Science. Fifty original articles were selected. Major findings included elevated levels serum proinflammatory cytokines individuals across various types, compared those without PTSD. Furthermore, altered associated structural functional regions responsible for regulation emotion, including amygdala, hippocampus, frontal cortex. Future utilize both central peripheral warranted elucidate pathway pathophysiology

Language: Английский

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The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 135, P. 111200 - 111200

Published: Jan. 1, 2021

The recent outbreak of the corona virus disease (COVID-19) has had major global impact. relationship between severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection and psychiatric diseases is great concern, with an evident link infections various central peripheral nervous system manifestations. Unmitigated neuro-inflammation been noted to underlie not only complications but also present in a range neuro-psychiatric illnesses. Several neurological disorders are characterized by immune-inflammatory states, while treatments for these have distinct anti-inflammatory properties effects. With inflammation being common contributing factor SARS-CoV-2, as well disorders, treatment either condition may affect progression other or alter response pharmacological treatment. In this review, we elucidate how viral could pre-existing conditions overall progress outcome SARS-CoV-2. We address whether any treatment-induced benefits potential adverse effects ultimately approach, considering underlying dysregulated neuro-inflammatory processes drug interactions. Finally, suggest adjunctive options SARS-CoV-2-associated symptoms.

Language: Английский

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Role of interleukin 8 in depression and other psychiatric disorders

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2020, Volume and Issue: 106, P. 110173 - 110173

Published: Nov. 10, 2020

Language: Английский

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Inflammatory and oxidative stress markers in post-traumatic stress disorder: a systematic review and meta-analysis

Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 27(8), P. 3150 - 3163

Published: April 27, 2022

Language: Английский

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Metabolic and Inflammatory Response in Post-Traumatic Stress Disorder (PTSD): A Systematic Review on Peripheral Neuroimmune Biomarkers

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(4), P. 2937 - 2937

Published: Feb. 8, 2023

Several heterogeneous pathophysiology pathways have been hypothesized for being involved in the onset and course of Post-Traumatic Stress Disorder (PTSD). This systematic review aims to summarize current evidence on role inflammation immunological dysregulations PTSD, investigating possible peripheral biomarkers linked neuroimmune response stress. A total 44 studies dysregulated inflammatory metabolic subjects with PTSD respect controls were included. Eligibility criteria included full-text publications English language, human adult samples, involving both a clinical diagnosis healthy control group. The research was focused specific blood biomarkers, namely IL-1β, TNF-α, IL-6 INF-γ, as well potential harmful reduced antioxidant activity (involving catalase, superoxide dismutase glutathione peroxidase). inflammatory-altered tryptophan metabolism also explored. results showed conflicting data pro-inflammatory cytokines individuals lack study regarding other mediators investigated. present suggests need further samples clarify pathogenesis define biomarkers.

Language: Английский

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Changes in the Serum Levels of Cytokines: IL-1β, IL-4, IL-8 and IL-10 in Depression with and without Posttraumatic Stress Disorder

Brain Sciences, Journal Year: 2022, Volume and Issue: 12(3), P. 387 - 387

Published: March 14, 2022

Both depressive disorders (DD) and post-traumatic stress (PTSD) are caused by immune system dysfunction. Affected individuals show increased proinflammatory cytokine concentration levels. Also, it has been hypothesized that DD PTSD might be associated with a generalized signature. The study assessed the of IL-1β, IL-4, IL-8 IL-10 in depression alone PTSD.The involved 460 participants. Out them, 420 subjects comprised group 40 control group. Each consisted 60 patients mild (MD), moderate (MOD), severe (SeD), MD (MD + PTSD), MOD (MOD SeD (SeD alone. All had serum measured ELISA.DD reflected It was reported mean levels increase as became more severe. A regular decrease noted onset exacerbation symptoms.The findings useful when considering chronic inflammation potential target or biomarker treatment.

Language: Английский

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Sex-dependent effects of microglial reduction on impaired fear extinction induced by single prolonged stress

Frontiers in Behavioral Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: Jan. 9, 2023

Single prolonged stress (SPS) is a preclinical rodent model for studying post-traumatic disorder (PTSD)-like behaviors. Previously we found that increased expression of the microglial marker Iba-1 in ventral hippocampus after SPS exposure was associated with impaired fear extinction, suggesting activity contributed to SPS-induced behavioral changes. To test this, examined whether reducing microglia colony-stimulating factor 1 receptor blocker, PLX3397, diet would prevent extinction impairment. Male rats exposed showed enhanced acquisition and memory. Adding PLX3397 prevented these In contrast, did not from impairing memory female rats. Despite sex-dependent effects, reduced number area fraction Iba-1+ both male had similar effects on sexes. Altogether, results suggest contribute changes induced by but

Language: Английский

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Association of pro-inflammatory cytokines with trauma and post-traumatic stress disorder visiting a tertiary care hospital in Kathmandu

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(2), P. e0281125 - e0281125

Published: Feb. 2, 2023

Post-traumatic stress disorder (PTSD) is a mental that can occur after trauma. Although inflammatory markers such as cytokines are found altered in trauma and PTSD, there no consensus regarding which be considered biomarkers. Studies from South Asia region also rare. We studied among affected patients matched healthy controls. Fifty (cases) with trauma, visiting the University hospital Kathmandu thirty-nine controls were selected, levels of determined using Luminex IS 200. compared thirty-four age gender pairs case control three groups: volunteers, cases diagnosed without PTSD. Among 34 pair-matched controls, IL-6 was significantly higher both PTSD positive [2.43 (0.00–14.54) pg/ml; p = 0.004] negative [3.00 (0.92–3.86) 0.005], than [0.39 (0.00–11.38) pg/ml]. IL-1β [0.17 (0.00–5.27) 0.011] 0.00 (0.00–0.12) pg/ml. Other did not show significant differences. groups group when to This supports immune system activation hypothesis

Language: Английский

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Learning from Hindsight: Examining Autonomic, Inflammatory, and Endocrine Stress Biomarkers and Mental Health in Healthy Terrorism Survivors Many Years Later

Prehospital and Disaster Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Jan. 8, 2025

Abstract Introduction: Terrorism and trauma survivors often experience changes in biomarkers of autonomic, inflammatory hypothalamic-pituitary-adrenal (HPA) axis assessed at various times. Research suggests interactions these systems chronic stress. Study Objective: This unprecedented retrospective study explores long-term stress three terrorism survivors. Methods: Sixty healthy, direct were compared to non-exposed community members for cardiovascular reactivity a script, morning salivary cortisol, interleukin 1-β (IL-1β), 2-R (IL-2R). Survivors’ correlated with psychiatric symptoms diagnoses reported functioning well-being seven years after the Oklahoma City (OKC) bombing. Main outcome measures Diagnostic Interview Schedule (DIS) Disaster Supplement Statistical Manual Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) diagnoses, Impact Events Scale-Revised (IES-R), Beck Depression Inventory-II (BDI-II), Distress Functioning Scale (DAF), General Physical Well-Being Scale. Results: Survivors had higher IL-1β, lower anti-inflammatory IL-2R, resting diastolic blood pressure (BP), less script than comparisons. mean posttraumatic (PTS) symptom levels did not differ from comparisons, but worse well-being. None survivors’ PTS or depressive functioning. Conclusions: Alterations biological cardiovascular, inflammatory, cortisol coexisted as an apparent generalized response rather related specific gauges mental health. Potential long exposure is discussed considering relevant research. Longer-term follow-up could determine whether continue correlate subjective measures, if they accompany health problems over time. Given recent international terrorism, understanding sequelae among increasingly relevant.

Language: Английский

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