Patient Perceptions of Microbiome-Based Therapies as Novel Treatments for Mood Disorders: A Mixed Methods Study: Perceptions des patients sur les thérapies basées sur le microbiome pour les troubles de l’humeur : une étude à méthodes mixtes DOI Creative Commons
Dina Moinul,

Chenhui Hao,

Gina Dimitropoulos

et al.

The Canadian Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 69(7), P. 503 - 512

Published: Feb. 28, 2024

Objective Medications are critical for treating major depressive disorder (MDD) and bipolar (BD). Unfortunately, 30% to 40% of individuals do not respond well current pharmacotherapy. Given the compelling growing body research on gut-brain axis, this study aims assess patient perspectives regarding microbiome-based therapies (MBT) such as probiotics, prebiotics, dietary changes, or fecal microbiota transplantation (FMT) in management MDD BD. Methods This single-centred observational used quantitative qualitative assessments examine perceptions MBT. Participants diagnosed with BD completed an anonymous questionnaire obtaining demographics, prior medication history, symptom burden. Self-assessment questionnaires specific each diagnosis were also used: Quick Inventory Depressive Symptomatology Self-Report (QIDS-SR), Altman Self-Rating Mania Scale (ASRM), General Anxiety Disorder Questionnaire (GAD-7). A logistic regression model analysed association MBT acceptance type, QIDS-SR, GAD-7 scores. bootstrap method assessed proportion acceptance. The assessment consisted 30-minute interviews elicit attitudes towards Results achieved information power n = 20. from 63-item ( 43) showed probiotics (37.2%) top choice, followed by FMT (32.6%), change (25.6%), prebiotics (4.6%). majority participants (72.1%) expressed willingness try their mood disorder, however, analysis did identify statistically significant predictors among GAD-7. Conclusion There is increased focus gut microbiota's role disorders’ etiology treatment. Promising interest underscore necessity exploring educating factors influencing

Language: Английский

Exploring Depression and Nutritional Covariates Amongst US Adults using Shapely Additive Explanations DOI Creative Commons
Alexander A. Huang, Samuel Y. Huang

Health Science Reports, Journal Year: 2023, Volume and Issue: 6(10)

Published: Oct. 1, 2023

Abstract Background Depression affects personal and public well‐being identification of natural therapeutics such as nutrition is necessary to help alleviate this health concern. Objective The study aimed identify feature importance in a machine learning model using solely covariates. Methods A retrospective analysis was conducted modern, nationally representative cohort, the National Health Nutrition Examination Surveys (NHANES 2017−2020). Depressive symptoms were evaluated validated 9‐item Patient Questionnaire (PHQ‐9), all adult patients (total 7929 individuals) who completed PHQ‐9 total nutritional intake questionnaire included study. Univariable regression used significant covariates be reported. acquisition data authorized by Center for Statistics Ethics Review Board. Results met inclusion criteria had 24 out 60 features that found on univariate ( p < 0.01 used). In XGBoost an Area Under Receiver Operator Characteristic Curve (AUROC) = 0.603, Sensitivity 0.943, Specificity 0.163. top four highest ranked gain, measure percentage contribution covariate overall prediction, Potassium Intake (Gain 6.8%), Vitamin E 5.7%), Number Foods Beverages Reported K 5.6%). Conclusion Machine models with can utilized further clinical depression.

Language: Английский

Citations

10

Adherence to the Mediterranean diet and depression, anxiety, and stress symptoms in Chilean university students: a cross-sectional study DOI Creative Commons
Gladys Morales, Teresa Balboa‐Castillo, Rubén Fernández‐Rodríguez

et al.

Cadernos de Saúde Pública, Journal Year: 2023, Volume and Issue: 39(10)

Published: Jan. 1, 2023

Abstract: This study aims to determine the association of adherence Mediterranean diet and its food groups with depressive symptoms in Chilean university students. The design was cross-sectional. A total 934 first-year students at a public completed self-report questionnaire. To assess diet, an index validated Chile (Chilean-MDI) used, depression, anxiety, stress were assessed using Depression Anxiety Stress Scale (DASS-21). Logistic regression models used analyze adjusted for main confounders. Students moderate high showed lower odds depression [DASS-21 > 5, ratio (OR) = 0.64; 95% confidence interval (95%CI): 0.47-0.88] than those low diet. consumption 1-2 servings/day vegetables (OR 0.63; 95%CI: 0.43-0.92), 2 servings/week nuts 0.41; 0.21-0.80), fruits 0.60; 0.42-0.85), fish seafood 0.67; 0.48-0.94), 1/2-3 units/week avocado 0.48-0.93) symptoms. whole grains cereals (> servings/day) 1.63; 1.02-2.61) opposite association. Adherence fruits, vegetables, nuts, avocado, fish, are associated likelihood New policies educational strategies recommended improve quality mental health entire community.

Language: Английский

Citations

7

EPA guidance on lifestyle interventions for adults with severe mental illness: A meta-review of the evidence DOI Creative Commons
Isabel Maurus, Sarah Wagner, Johanna Spaeth

et al.

European Psychiatry, Journal Year: 2024, Volume and Issue: 67(1)

Published: Jan. 1, 2024

Abstract There is growing interest in lifestyle interventions as stand-alone and add-on therapies mental health care due to their potential benefits for both physical outcomes. We evaluated focusing on activity, diet, sleep adults with severe illness (SMI) the evidence effectiveness. To this end, we conducted a meta-review searched major electronic databases articles published prior 09/2022 updated our search 03/2024. identified 89 relevant systematic reviews assessed quality using SIGN checklist. Based findings of clinical expertise authors, formulated seven recommendations. In brief, supports application that combine behavioural change techniques, dietary modification, activity reduce weight improve cardiovascular parameters SMI. Furthermore, should be used an adjunct treatment SMI, including psychotic symptoms cognition schizophrenia or depressive depression. ameliorate quality, cognitive informed can considered. Additionally, provide overview key gaps current literature. Future studies integrate outcomes reflect multi-faceted interventions. Moreover, highlighted relative dearth relating bipolar disorder nutritional research could help establish core component care.

Language: Английский

Citations

2

Protein-enriched and anti-inflammatory dietary patterns, healthy lifestyle index and depressive symptoms: A cross-sectional study of 287,945 adults in China DOI

Xiaoqian Dong,

Yaqin Wang, Yue Kang

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 351, P. 863 - 869

Published: Feb. 9, 2024

Language: Английский

Citations

1

Patient Perceptions of Microbiome-Based Therapies as Novel Treatments for Mood Disorders: A Mixed Methods Study: Perceptions des patients sur les thérapies basées sur le microbiome pour les troubles de l’humeur : une étude à méthodes mixtes DOI Creative Commons
Dina Moinul,

Chenhui Hao,

Gina Dimitropoulos

et al.

The Canadian Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 69(7), P. 503 - 512

Published: Feb. 28, 2024

Objective Medications are critical for treating major depressive disorder (MDD) and bipolar (BD). Unfortunately, 30% to 40% of individuals do not respond well current pharmacotherapy. Given the compelling growing body research on gut-brain axis, this study aims assess patient perspectives regarding microbiome-based therapies (MBT) such as probiotics, prebiotics, dietary changes, or fecal microbiota transplantation (FMT) in management MDD BD. Methods This single-centred observational used quantitative qualitative assessments examine perceptions MBT. Participants diagnosed with BD completed an anonymous questionnaire obtaining demographics, prior medication history, symptom burden. Self-assessment questionnaires specific each diagnosis were also used: Quick Inventory Depressive Symptomatology Self-Report (QIDS-SR), Altman Self-Rating Mania Scale (ASRM), General Anxiety Disorder Questionnaire (GAD-7). A logistic regression model analysed association MBT acceptance type, QIDS-SR, GAD-7 scores. bootstrap method assessed proportion acceptance. The assessment consisted 30-minute interviews elicit attitudes towards Results achieved information power n = 20. from 63-item ( 43) showed probiotics (37.2%) top choice, followed by FMT (32.6%), change (25.6%), prebiotics (4.6%). majority participants (72.1%) expressed willingness try their mood disorder, however, analysis did identify statistically significant predictors among GAD-7. Conclusion There is increased focus gut microbiota's role disorders’ etiology treatment. Promising interest underscore necessity exploring educating factors influencing

Language: Английский

Citations

1