Mendelian randomization study reveals the relationship between dietary factors and respiratory diseases

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 18, 2023

Abstract The existence of causal relationship between dietary factors and respiratory diseases is uncertain. We comprehensively investigated the association by using Mendelian randomization (MR). Genetic variants linked to were selected as instrumental variables with genome-wide significance. These obtained from large GWAS databases. databases include Biobank, FinnGen study, other consortia. used multivariate MR analyses control effects smoking education. Median analysis was conducted evaluate whether body mass index (BMI) played a role in diseases. Dried fruit intake found be associated decreased risk chronic obstructive pulmonary disease (COPD) (OR: 0.211; 95% CI 0.117–0.378; P < 0.001) asthma 0.539; 0.357–0.815; = 0.003). Conversely, pork an increased international pharmaceutical federation (IPF) 1.051*10 2 , 4.354–2.56*10 3 0.004). However, no significant associations observed 20 sleep apnea (OSA). In addition, showed that above results unchanged nonsmoking populations, while effect dried on significantly attenuated after corrective mediator variable indicated BMI could serve results. This study fruits slowed progression COPD asthma, promoted IPF. OSA found. Meanwhile, we non-smoking populations. contrast, education influence diet mediating

Language: Английский

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Gut microbiota and risk of endocarditis: a bidirectional Mendelian randomization study

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 17, 2024

Background The associations between gut microbiota and cardiovascular disease have been reported in previous studies. However, the relationship endocarditis remains unclear. Methods A bidirectional Mendelian randomization (MR) study was performed to detect association endocarditis. Inverse variance weighted (IVW) method considered main result. Simultaneously, heterogeneity pleiotropy tests were conducted. Results Our suggests that family Victivallaceae ( p = 0.020), genus Eubacterium fissicatena group 0.047), Escherichia Shigella 0.024), Peptococcus 0.028) Sellimonas 0.005) play protective roles Two microbial taxa, including Blautia 0.006) Ruminococcus2 0.024) increase risk of At same time, has a negative effect on 0.048). Besides, no or found this study. Conclusion emphasized certain role specific patients with clarified microbiota.

Language: Английский

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The causality between gut microbiome and chronic regional pain: a Mendelian randomization analysis

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 29, 2024

Background Numerous investigations have underscored the causal effect between chronic pain (CP) and gut microbiota, jointly contributing to onset development of widespread CP. Nonetheless, there was still uncertainty about microbiota regional (CRP). Methods Genome-wide association study (GWAS) summary data microbial taxa (MiBioGen Consortium: 211 microbiotas Dutch Microbiome Project: 207 microbiotas) eight types CRP were used reveal persistent in a specific region body microbiota. A two-sample bidirectional Mendelian randomization (MR) design used. In order ensure accuracy results, multiple sensitivity analyses employed. Results This uncovered significant associations six three (forward: Genus Parabacteroides for general pain; Class Bacteroidia , Order Bacteroidales, Phylum Bacteroidetes back pain. Reverse: knee Howardella Coriobacteriales ) by forward reverse MR analysis. These findings had been verified rigorous Bonferroni correction. Furthermore, this research identified 19 that exhibited potential correlations with four CRP. There are no or associated other CRP, including fascial pain, stomach abdominal hip Conclusion analysis unveiled causality conditions. The interplay 6 while also delineating corresponding diverse locations

Language: Английский

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Pancreatitis affects gut microbiota via metabolites and inflammatory cytokines: an exploratory two-step Mendelian randomisation study

Molecular Genetics and Genomics, Journal Year: 2024, Volume and Issue: 299(1)

Published: March 16, 2024

Abstract Previous studies have observed relationships between pancreatitis and gut microbiota; however, specific changes in microbiota abundance underlying mechanisms remain unknown. Metabolites are important for to fulfil their biological functions, the metabolic immune environments closely linked abundance. We aimed clarify of gut–pancreas interactions explore possible role metabolites system. To this end, we conducted two-sample Mendelian randomisation (MR) analysis evaluate casual links four different types microbiota, metabolites, inflammatory cytokines. A two-step MR was further probable mediating pathways involving cytokines causal relationship microbiota. In total, six potential mediators were identified Nineteen species seven genetically associated with pancreatitis. involved glucose amino acid metabolisms chronic pancreatitis, those lipid metabolism acute Our study alterations at genetic level found pancreas–gut axis, which may provide insights into precise diagnosis treatment interventions prevent exacerbation Future could elucidate mechanism association

Language: Английский

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Relationships between the gut microbiome and brain functional alterations in first-episode, drug-naïve patients with major depressive disorder

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 362, P. 578 - 584

Published: July 6, 2024

Language: Английский

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