Cited by Association between cardiorenal syndrome and depressive symptoms among the US population: a mediation analysis via lipid indices

Prebiotics modulate the microbiota–gut–brain axis and ameliorate anxiety and depression-like behavior in HFD-fed mice DOI

Igor Henrique Rodrigues de Paiva,

Laís Macêdo Maciel, Rodrigo Soares da Silva

et al.

Food Research International, Journal Year: 2024, Volume and Issue: 182, P. 114153 - 114153

Published: Feb. 23, 2024

Language: Английский

Citations

Serotonin Signaling through Lipid Membranes DOI

Liubov S. Kalinichenko, Johannes Kornhuber, Steffen Sinning

et al.

ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(7), P. 1298 - 1320

Published: March 18, 2024

Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most behaviors in the brain. An inefficient 5-HT synaptic function often linked to various mental disorders. Primarily, membrane proteins controlling expression and activity of synthesis, storage, release, receptor activation, inactivation are critical signaling extra-synaptic sites. Moreover, these signals represent information transmission across membranes. Although lipid environment viewed as fairly stable, emerging research suggests significant functional lipid–protein interactions with many proteins. These protein–lipid extend almost all primary classes that form plasma membrane. Collectively, affect efficacy at synapse. The highly dynamic composition membranes lipids their may contribute plasticity Therefore, this broader model synapse necessitates reconsideration 5-HT's role associated

Language: Английский

Citations

Exploring the impacts of ketogenic diet on reversible hepatic steatosis: initial analysis in male mice DOI

Gaétan Ravaut,

Anthony Carneiro,

Cathérine Mounier

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: March 21, 2024

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common chronic disease. Ketogenic diet (KD), a with very low intake in carbohydrates, gained popularity as weight-loss approach. However, mice models, it has been reported that an excess exposition of dietary fat induces hepatic insulin resistance and steatosis. data published inconsistent. Herein, we investigated mouse model, metabolic effects KD its contribution to pathogenesis NALFD. Mice were exposed or CHOW for 12 weeks while third group was also then switched 4 determine if can rescue phenotype. We evaluated treatments on distribution, glucose, homeostasis well fed developed glucose intolerance but not accompanied by increase inflammation. KD-fed showed accumulation white adipose tissue liver. This effect could be explained uptake no changes catabolism leading MAFLD. Interestingly, able phenotype switching diet. Our studies demonstrate even develop steatosis after KD, they do more importantly, reversed from CHOW.

Language: Английский

Citations

Acipimox mitigates depression like behavior following high fat rich diet in rats DOI

Natasha Manzoor,

Noreen Samad,

Saima Khaliq

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111342 - 111342

Published: April 1, 2025

Language: Английский

Citations

Body Roundness Index Trajectories and the Risk of Cancer: A Cohort Study DOI

Yue Chen, Yiming Wang, Xin Zheng

et al.

Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(23)

Published: Nov. 28, 2024

ABSTRACT Background The body rounds index (BRI), an innovative obesity indicator integrating waist circumference (WC) and height, offers a two‐dimensional assessment of obesity. relationship between BRI trajectories cancer has been overlooked in previous studies. This study aims to explore the association incidence cancer. Methods included 42,022 participants with median age 48.91 years. Based on changes participants' during period from 2006 2010, three trajectory patterns were identified: low‐stable, medium‐stable, high‐stable. primary outcome was secondary cancer‐specific deaths. death explored by cox regression analysis total, sex‐specific age‐specific populations, respectively. Additionally, we further investigated site‐specific incidence. Sensitivity analyses applied exclude interferences ensure stability results. Results After follow‐up time 11.04 years, high‐stable significantly associated increased risk occurrence compared low‐stable trajectory. more pronounced middle‐aged men (men: HR = 1.46, 95% CI 1.21–1.77, p < 0.001; 65: 11.38, 1.15–1.66, 0.001). substantial increase uterine cancers (HR 4.92, 1.69–14.33, 0.004). confirmed Conclusion Our identified significant incidence, this being most men. Moreover, strongly development. findings underscore importance implementing lifestyle modifications monitoring values their provide effective health guidance.

Language: Английский

Citations

Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus DOI

Tianbao Wang,

Ying He,

Rui-Cheng Li

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 126, P. 155448 - 155448

Published: Feb. 12, 2024

Language: Английский

Citations

From blood to brain: Exploring the role of fibrinogen in the pathophysiology of depression and other neurological disorders DOI

Shashikant Patel,

Venkatesh Govindarajan,

Sumana Chakravarty

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113326 - 113326

Published: Oct. 10, 2024

Language: Английский

Citations

Amelioration impact of gut-brain communication on obesity control by regulating gut microbiota composition through the ingestion of animal-plant-derived peptides and dietary fiber: can food reward effect as a hidden regulator? DOI

Wei Jia, Jian Peng, Yan Zhang

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(31), P. 11575 - 11589

Published: Aug. 1, 2023

Various roles of intestinal flora in the gut-brain axis response pathway have received enormous attention because their unique position flora-derived metabolites regulating hormones, inducing appetite, and modulating energy metabolism. Reward pathways brain play a crucial role communications, but mechanisms not been methodically understood. This review outlined by which leptin, ghrelin, insulin are influenced to regulate appetite body weight, focused on significance paraventricular nucleus ventromedial prefrontal cortex food reward. The vagus nerve mitochondria essential involved modulation neurotransmitters, neural signaling, neurotransmission communications. dynamic nutrient intake changes characteristics feeding activity requires participation transmit messages be completed. SCFAs, Bas, BCAAs, induced hormones mediate sensory information reward signaling host complex regulatory mechanism selection, composition significantly impacts this process. Food process obesity based communications expands new ideas for prevention treatment obesity.

Language: Английский

Citations

Pitavastatin attenuates hypercholesterolemia-induced decline in serotonin transporter availability DOI

Sy‐Jou Chen,

Rou-Ling Cho,

Skye Hsin‐Hsien Yeh

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 17, 2024

Hypercholesterolemia is associated with increased inflammation and impaired serotonin neurotransmission, potentially contributing to depressive symptoms. However, the role of statins, particularly pitavastatin, in modulating transporter (SERT) function within this context remains underexplored. This study aimed investigate whether pitavastatin counteracts neurobiological effects hypercholesterolemia.

Language: Английский

Citations

Long-Term High-Fat Diet Aggravates Absence Seizures and Neurobehavioral Disorders Without Inducing Metabolic Disorders in WAG/Rij Rats: Involvement of Systemic and Central Inflammation DOI

Lorenza Guarnieri, Francesca Bosco, Stefano Ruga

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 62(4), P. 4837 - 4853

Published: Nov. 2, 2024

Language: Английский

Citations