The Relationship Between Perioperative Use of Esketamine and Postpartum Depression Risk: A Systematic Review and Meta-Analysis of Randomized Controlled Trials DOI Creative Commons

Yuansheng Cao,

Lijuan Fu, Xianjie Zhang

et al.

Neuropsychiatric Disease and Treatment, Journal Year: 2024, Volume and Issue: Volume 20, P. 1041 - 1048

Published: May 1, 2024

Purpose: To determine whether perioperative esketamine use decreases the risk of postpartum depression (PPD). Methods: Online search PubMed, Web Science, and Embase was conducted to identify relevant studies. Key words for included, but were not limited to, depression, esketamine, clinical trials. The mean standard deviation Edinburgh Postnatal Depression Scale (EPDS) scores extracted from studies as primary parameters. Results: literature identified 226 articles, which 5 met criteria enrolled in study. In total, 886 patients taken into analysis. EPDS group lower than those control at early stage puerperium (WMD=− 2.05, 95% CI: − 3.77, 0.34, p =0.019), whereas there no significant difference middle later stages 1.41, 2.86, 0.04, =0.056). sensitivity analyses indicated that result stable, it unreliable stages. results Egger's test publication bias. Conclusion: Perioperative contributes a PPD further verify this conclusion, more high-quality are required. Keywords: pregnant women, mental health

Language: Английский

Efficacy and safety of esketamine for perioperative depression in patients undergoing elective surgery: A meta-analysis of randomized controlled trials DOI

Xue-jie Lou,

Di Qiu,

Zhuo-Yu Ren

et al.

Asian Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 95, P. 103997 - 103997

Published: March 11, 2024

Language: Английский

Citations

8
Efficacy and safety of peri-partum Esketamine for prevention of post-partum depression in women undergoing caesarian section: A Meta-Analysis and Systematic Review of Randomized Controlled Trials DOI

Muhammad Anas Nayyer,

Suchna Meeral Khan,

Mohammad Umer

et al.

Asian Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 97, P. 104090 - 104090

Published: May 21, 2024

Language: Английский

Citations

8
Perioperative esketamine administration for prevention of postpartum depression after the cesarean section: A systematic review and meta-analysis DOI
Mohammadamin Parsaei,

Seyedeh Melika Hasehmi,

Homa Seyedmirzaei

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 361, P. 564 - 580

Published: June 24, 2024

Language: Английский

Citations

6
Esketamine alleviates ferroptosis-mediated acute lung injury by modulating the HIF-1α/HO-1 pathway DOI

Jinye Shi,

Shuang Song, Yajie Wang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113065 - 113065

Published: Sept. 7, 2024

Language: Английский

Citations

6
Effect of intraoperative and/or postoperative esketamine administration on preventing postpartum depression: A systematic review and meta-analysis DOI
Jinping Wang, Hui Liu,

Xinchuan Wei

et al.

Psychiatry Research, Journal Year: 2024, Volume and Issue: 335, P. 115890 - 115890

Published: April 2, 2024

Language: Английский

Citations

5
Effects of perioperative application of esketamine on postpartum depression in cesarean section: A systematic review and meta-analysis DOI Creative Commons
Baoyu Ma,

Xinyi Tao,

Yanyu Qi

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(27), P. e38821 - e38821

Published: July 5, 2024

Background: To evaluate the effect of perioperative esketamine administration on postpartum depression in pregnant women undergoing cesarean section. Methods: Data sources was PubMed, Embase, Web Science, and Cochrane Library from inception to February 1, 2024. Randomized controlled trials section were selected compared use period. The primary outcome measure incidence maternal depression. Preferred reporting items for systematic reviews meta-analyses used. pooled by random-effects models are presented as risk ratios (RR) (95% confidence intervals, 95% CI) or mean differences CI). This review registered PROSPERO (ID: CRD42023431197). Results: We included 8 studies with a total 1655 participants. quality rated high unclear. Seven involving 1485 participants reported Compared without esketamine, those using period showed 48% decreased developing (RR: 0.52, CI: 0.35–0.79) 1.43-point reduction EPDS (Edinburgh Postnatal Depression Scale) (mean difference: −1.43, −2.32 −0.54). For immediate intraoperative adverse reactions, application caused nausea vomiting 2.16, 1.22–3.81), dizziness 6.11, 1.49–24.98), hallucinations 6.83, 1.57–29.68) no use. Conclusions: Perioperative may reduce increase but has significant postoperative reactions.

Language: Английский

Citations

4
Prevention of sufentanil-induced cough during induction of general anesthesia by low-dose esketamine DOI Creative Commons

Xueyue Zhou,

Chaoping Guo, Boyu Liu

et al.

BMC Anesthesiology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 8, 2025

Language: Английский

Citations

0
Efficacy and safety of ketamine and esketamine in reducing the incidence of postpartum depression: an updated systematic review and meta-analysis DOI Creative Commons
Moaz Yasser Darwish, Abdallah A. Helal, Yousif Ahmed Othman

et al.

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 6, 2025

Abstract Background Postpartum depression (PPD) is categorized by the Disorders-Fifth Edition as that begins during pregnancy or within first month after giving birth. Ketamine and esketamine have shown promising results in treatment of several depressive disorders, which suggests they may a role prevention PPD. This systematic review meta-analysis aim to update evidence about efficacy safety using ketamine reduce PPD incidence. Methods We searched four databases, PubMed, Scopus, Web Science, Cochrane, collect relevant studies. included studies investigated preventive effect on among women birth through caesarean vaginal delivery. extracted occurrence rate, score, pain score side effects. Finally, was conducted RevMan software. Results Twenty-one eligible were incorporated current involving 4,389 pregnant women. Esketamine intervention 14 studies, used 7 In subgroup analysis, both significantly effective reducing incidence short-term (ketamine: RR = 0.72, 95% CI [0.56, 0.93], P 0.01; esketamine: 0.43, < 0.0001). only reduced long-term (RR 0.44, 0.00001). Low doses high (high dose: 0.48, 0.0005; low 0.46, 0.002) 0.54, 0.0001; 0.61, 0.009). Regarding risk effects, patients Ketamine/esketamine group showed statistically significant higher rates developing dizziness ( 0.0007), blurred vision 0.02), vomiting 0.004) hallucinations 0,002) than control group. Conclusion Both are lowering On other hand, It recommended use smaller for more tolerable period since less 0.5 mg effective. Temporary effects such dizziness, vision, reported.

Language: Английский

Citations

0
Intraoperative Esketamine and Postpartum Depression Among Women With Cesarean Delivery DOI Creative Commons
Li Ren, Ting Zhang,

Bingyu Zou

et al.

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(2), P. e2459331 - e2459331

Published: Feb. 13, 2025

Importance Esketamine has been found to reduce the incidence of postpartum depression (PPD) in randomized clinical trials. However, current evidence from trials does not reflect esketamine’s efficacy settings. Objective To assess intraoperative esketamine administration for preventing PPD among women who underwent cesarean delivery. Design, Setting, and Participants This trial was conducted at The First Affiliated Hospital Chongqing Medical University Chongqing, China, March 2023 February 2024. Pregnant patients admitted delivery were included, while those with intellectual dysfunction or contraindications excluded. All participants assigned randomly either group control a 1:1 ratio. Data analysis based on intention-to-treat principle. Interventions Patients received an infusion 0.25 mg/kg 20 mL saline over minutes, whereas minutes. Main Outcomes Measures primary outcome 6 weeks post partum. assessed using Edinburgh Postnatal Depression Scale. Results A total 308 pregnant 1 2 groups: (n = 154; mean [SD] patient age, 31.57 [4.26] years) 32.53 [7.74] years). Incidence significantly lower compared partum (10.4% [16] vs 19.5% [30]; relative risk, 0.53; 95% CI, 0.30-0.93; P .02). Conclusions Relevance demonstrated advantage reducing safety warrant further investigation practice. Trial Registration Chinese Clinical Registry Identifier: ChiCTR2200065494

Language: Английский

Citations

0
Effect of intravenous esketamine on postoperative sleep disturbance, anxiety, and depression in elderly patients undergoing laparoscopic abdominal surgery: a randomized controlled trial DOI Creative Commons
Haijin Wang,

Lan Wang,

Jing Gao

et al.

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 5, 2025

The population of elderly individuals undergoing surgical procedures is increasing, necessitating effective postoperative management strategies. Postoperative sleep disturbance, anxiety, and depression are significant contributors to overall recovery in this demographic, especially following laparoscopic abdominal surgery. This study included 200 records patients Patients were divided into an esketamine group, receiving intravenous esketamine, a control normal saline. Parameters such as surgery anesthesia duration, fluid volume, blood loss, urine output, depression, pain assessment, adverse events compared between the two groups. group had significantly fewer disturbances, lower anxiety scores on days 1 3, Visual Analog Scale (VAS) (P < 0.05). They also required less rescue analgesia, used opioids, consumed non-opioid analgesics However, experienced higher incidence dissociative symptoms 0.05), while other similar Overall, improved reduced but increased risk symptoms. Intravenous administration was associated with scores, decreased analgesia requirements, opioid consumption, use analgesic medications. clinical registered at Chinese Clinical Trial Registry (ChiCTR, ChiCTR2400087795).

Language: Английский

Citations

0