A Bibliometric Analysis of Pyroptosis From 2001 to 2021

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Aug. 18, 2021

Pyroptosis is a new programmed cell death discovered in recent years. plays an important role various diseases. Nevertheless, there are few bibliometric analysis systematically studies this field. We aimed to visualize the research hotspots and trends of pyroptosis using help understand future development basic clinical research.The articles reviews regarding were culled from Web Science Core Collection. Countries, institutions, authors, references keywords field visually analyzed by CtieSpace VOSviewer software.A total 2845 included. The number significantly increased yearly. These publications mainly come 70 countries led China USA 418 institutions. identified 605 among which Thirumaladevi Kanneganti had most significant articles, Shi JJ was co-cited often. Frontiers immunology journal with studies, Nature commonly cited journal. After analysis, common nod like receptor family pyrin domain containing 3 inflammasome, apoptosis, death, gasdermin D, mechanism, caspase-1, others current developing areas study.Research on flourishing. Cooperation exchanges between institutions must be strengthened future. related pathway mechanism pyroptosis, relationship other types deaths as well diseases have been focus developmental research.

Language: Английский

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Urolithin A alleviates NLRP3 inflammasome activation and pyroptosis by promoting microglial mitophagy following spinal cord injury

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114057 - 114057

Published: Jan. 18, 2025

Language: Английский

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Long-read sequencing of 945 Han individuals identifies structural variants associated with phenotypic diversity and disease susceptibility

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 10, 2025

Genomic structural variants (SVs) are a major source of genetic diversity in humans. Here, through long-read sequencing 945 Han Chinese genomes, we identify 111,288 SVs, including 24.56% unreported variants, many with predicted functional importance. By integrating human population-level phenotypic and multi-omics data as well two humanized mouse models, demonstrate the causal roles SVs: one SV that emerges at common ancestor modern humans, Neanderthals, Denisovans GSDMD for bone mineral density modern-human-specific WWP2 impacting height, weight, fat, craniofacial phenotypes immunity. Our results suggest could serve rapid cost-effective biomarker assessing risk cisplatin-induced acute kidney injury. The conservation from to widespread signals positive natural selection both SVs likely influence local adaptation, diversity, disease susceptibility across diverse populations. Genetic studies individuals have been performed, but mostly short read sequencing, limiting types can be identified. authors perform long han individuals, finding under those associated traits evolutionary history.

Language: Английский

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BMSC-Derived Exosomes Ameliorate Osteoarthritis by Inhibiting Pyroptosis of Cartilage via Delivering miR-326 Targeting HDAC3 and STAT1//NF-κB p65 to Chondrocytes

Mediators of Inflammation, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 26

Published: Nov. 2, 2021

In the past decade, mesenchymal stem cells (MSCs) have been widely used for treatment of osteoarthritis (OA), and noncoding RNAs in exosomes may play a major role.The present study is aimed at exploring effect mechanism miR-326 secreted by bone marrow (BMSCs) on pyroptosis cartilage OA improvement.Exosomes from BMSCs (BMSC-Exos) were isolated identified to incubate with chondrocytes. Proliferation, migration, specific gene expression, chondrocytes detected. or transfected mimics inhibitors investigate BMSC-Exos potential mechanism. Finally, rat model was established verify pyroptosis.Incubation could significantly improve survival rate, migration ability, chondrocyte-specific genes (COL2A1, SOX9, Agg, Prg4) expression inhibit downregulation levels inflammatory cytokines, Caspase-1 activity, pyroptosis-related proteins such as GSDMD, NLRP3, ASC, IL-1β, IL-18 (P < 0.01). PKH26 labeling confirmed uptake Incubation extracted overexpressing can repress chondrocytes, while knockdown had opposite The same result also demonstrated direct interference level addition, we found that overexpression inhibited HDAC3 NF-κB p65 promoted STAT1, acetylated targeted relationship between verified dual-luciferase reporter assay. Animal experiments which delivered inhibits targeting STAT1/NF-κB signaling pathway.BMSC-Exos deliver STAT1//NF-κB cartilage. Our findings provide new treat OA.

Language: Английский

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GSDMD-mediated pyroptosis: a critical mechanism of diabetic nephropathy

Expert Reviews in Molecular Medicine, Journal Year: 2021, Volume and Issue: 23

Published: Jan. 1, 2021

Pyroptosis is a recently identified mechanism of programmed cell death related to Caspase-1 that triggers series inflammatory reactions by releasing several proinflammatory factors such as IL-1β and IL-18. The process characterised the rupture membranes release contents through mediation gasdermin (GSDM) proteins. GSDMD an important member GSDM family plays critical role in two pathways pyroptosis. Diabetic nephropathy (DN) microvascular complication diabetes major cause end-stage renal disease. Recently, it was revealed GSDMD-mediated pyroptosis occurrence development DN. In this review, we focus on types kidney cells, tubular epithelial cells podocytes, illustrate DN provide new ideas for prevention, early diagnosis molecular therapy

Language: Английский

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Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response

Biochemical Pharmacology, Journal Year: 2021, Volume and Issue: 195, P. 114863 - 114863

Published: Nov. 30, 2021

Language: Английский

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Exosomal miR-17-5p from adipose-derived mesenchymal stem cells inhibits abdominal aortic aneurysm by suppressing TXNIP-NLRP3 inflammasome

Stem Cell Research & Therapy, Journal Year: 2022, Volume and Issue: 13(1)

Published: July 26, 2022

Preclinical studies have suggested that adipose-derived mesenchymal stem cells (ADSCs) transplantation can suppress abdominal aortic inflammation and aneurysm expansion through paracrine factors. Yet, the mechanism of action is not fully understood. In present study, we further examined function ADSC-derived exosomes (ADSC-exos) their microRNA-17-5p (miR-17-5p) on (AAA) progression.ADSC-exos were isolated identified. DiR PKH67 staining used to trace ADSC-exo in vivo vitro. Raw264.7 applied perform vitro experiments, while a murine AAA model induced using angiotensin II (Ang II) was for testing. The expression level miR-17-5p macrophages Ang II-treated after ADSC-exos treatment determined reverse transcription-quantitative polymerase chain reaction (RT-qPCR). target relation between thioredoxin-interacting protein (TXNIP) identified by dual-luciferase reporter gene assay. Artificial activation block experiments TXNIP conducted clarify functions during progression. severity groups assessed maximal aorta diameter, incidence, survival rate, histological stainings. Besides, inflammasome-related proteins macrophage pyroptosis evaluated western blot, RT-qPCR, enzyme-linked immunosorbent assay (ELISA).The testing showed mainly distributed liver. Meanwhile, taken up macrophages, inside, decreased directly binding its 3'-untranslated region (3'UTR). Furthermore, overexpression enhanced therapeutic vivo, inhibition reversed this process. Finally, overexpressed triggered alleviated vitro.ADSC-exos regulated progression via TXNIP-NLRP3 signaling pathway, thus providing novel insight treatment.

Language: Английский

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Exosome-Shuttled miR-672-5p from Anti-Inflammatory Microglia Repair Traumatic Spinal Cord Injury by Inhibiting AIM2/ASC/Caspase-1 Signaling Pathway Mediated Neuronal Pyroptosis

Journal of Neurotrauma, Journal Year: 2022, Volume and Issue: 39(15-16), P. 1057 - 1074

Published: March 4, 2022

Traumatic spinal cord injury (TSCI) is a devastating traumatic disease of the central nervous system, which leads to refractory loss motor and sensory function. So far, there no effective treatment for TSCI. Recently, however, nano-sized exosomes from various cells have shown great prospects in diseases, including Microglia are one components microenvironment. Anti-inflammatory microglia (M2) been inhibit inflammation promote functional recovery after However, role micro RNAs (miRNAs) derived M2 TSCI unclear. In this study, we investigated whether microglial (M2-Exos) could better behavior mice with than M0 (Exos). Compared Exos, M2-Exos were found effect promoting behavior, axon regeneration reducing level pyroptosis neurons Through series experiments, also confirmed that miR-672-5p most critical miRNA associated M2-Exos, its targeting gene AIM2. rich AIM2/ASC/caspase-1 signaling pathway by inhibiting AIM2 activity, so as neuronal finally conclusion, our study suggests application may be promising strategy

Language: Английский

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Treg cell-derived exosomes miR-709 attenuates microglia pyroptosis and promotes motor function recovery after spinal cord injury

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Dec. 13, 2022

Abstract Neuroinflammation is an important cause of poor prognosis in patients with spinal cord injury. pyroptosis a new type inflammatory cell death. Treg cells has been shown to play anti-inflammatory role variety diseases, including bowel disease, amyotrophic lateral sclerosis, and arthritis. However, little known about cells' potential following The aim this research was look into the effect motor function recovery, mechanism behind it after SCI. Here, we found that mainly occurred microglia on seventh day Konckout resulted widely recovery In conversely, over-infiltration mice by tail vein injection had beneficial effects SCI.Treg cell-derived exosomes promote functional inhibiting vivo. Bioinformatic analysis revealed miRNA-709 significantly enriched cell-secreted exosomes. NKAP identified as target gene. Moreover, experiments confirmed targeted via exosomal miR-709 reduce More importantly, overexpressed constructed reduced response improved brief, our findings indicate possible for communication between microglia, which opens up perspective alleviating neuroinflammation

Language: Английский

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Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO-1 signaling pathway

Redox Biology, Journal Year: 2023, Volume and Issue: 68, P. 102938 - 102938

Published: Oct. 18, 2023

To investigate the therapeutic potential of dimethyl fumarate (DMF) in improving erectile function bilateral cavernous nerve injury (BCNI) rats, along with elucidating its underlying mechanisms.

Language: Английский

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