Overview of analytical methods for the determination of microplastics: Current status and trends

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 167, P. 117261 - 117261

Published: Sept. 1, 2023

Language: Английский

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MicroRaman spectroscopy detects the presence of microplastics in human urine and kidney tissue

Environment International, Journal Year: 2024, Volume and Issue: 184, P. 108444 - 108444

Published: Jan. 19, 2024

There is a growing concern within the medical community about potential burden of microplastics on human organs and tissues. In this study, we investigated by microRaman spectroscopy presence in kidneys urine. Moreover, an open-access software was developed validated for project, which enabled comparison between spectra self-created spectral database, thus enhancing ability to characterize polymers pigments biological matrices. Healthy portions ten obtained from nephrectomies, as well urine samples healthy donors were analyzed: 26 particles both kidney identified, with sizes ranging 3 13 μm 1 29 kidneys. The most frequently determined are polyethylene polystyrene, while common hematite Cu-phthalocyanine. This preclinical study proves renal tissues confirms their urine, providing first evidence deposition humans.

Language: Английский

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Human Microplastics Exposure and Potential Health Risks to Target Organs by Different Routes: A Review

Current Pollution Reports, Journal Year: 2023, Volume and Issue: 9(3), P. 468 - 485

Published: Aug. 17, 2023

Language: Английский

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Microplastic migration and distribution in the terrestrial and aquatic environments: A threat to biotic safety

Journal of Environmental Management, Journal Year: 2023, Volume and Issue: 333, P. 117412 - 117412

Published: Feb. 7, 2023

Language: Английский

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Low-dose of polystyrene microplastics induce cardiotoxicity in mice and human-originated cardiac organoids

Environment International, Journal Year: 2023, Volume and Issue: 179, P. 108171 - 108171

Published: Aug. 25, 2023

Microplastic particles (MP) are prevalent in both industrial production and the natural environment, posing a significant concern for human health. Daily diet, air inhalation, skin contact major routines of MP intake human. The main injury target systems MPs include digestive system, respiratory cardiovascular system. However, study on MPs' adverse effects heart is less than other organs. Previous vivo studies have demonstrated that can induce injuries, including abnormal rate, apoptosis cardiomyocytes, mitochondrial membrane potential change, fibrin overexpression. To address animal welfare concerns overcome inter-species variations, this employed pluripotent stem cell-derived vitro three-dimensional cardiac organoid (CO) model to investigate heart. distinct cavities COs allowed observation aggregation spatial distribution following polystyrene-MP (PS) exposure dynamic After various concentrations PS (0.025, 0.25 2.5 µg/mL, with lowest concentration equivalent internal levels), exhibited increased oxidative stress, inflammatory response, apoptosis, collagen accumulation. These findings were consistent observations, terms increases interventricular septal thickness. expression hypertrophic-related genes (MYH7B/ANP/BNP/COL1A1) changed noticeably cardiac-specific markers MYL2/MYL4/CX43 also markedly elevated. Our revealed could induced hypertrophy vitro, indicating may be an under-recognized risk factor

Language: Английский

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Micro- and nano-plastics in the atmosphere: A review of occurrence, properties and human health risks

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 465, P. 133412 - 133412

Published: Jan. 9, 2024

Language: Английский

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Acute Exposure to Microplastics Induced Changes in Behavior and Inflammation in Young and Old Mice

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12308 - 12308

Published: Aug. 1, 2023

Environmental pollutants have become quite ubiquitous over the past two centuries; of those, plastics, and in particular, microplastics (<5 mm), are among most pervasive pollutants. Microplastics (MPs) found their way into air, water system, food chain either purposely produced or derived from breakdown larger plastic materials. Despite societal advancements that plastics allowed, mismanagement waste has a pressing global issue. Pioneering studies on MPs toxicity shown exposure to induces oxidative stress, inflammation, decreased cell viability marine organisms. Current research suggests these transported throughout environment can accumulate human tissues; however, health effects MPs, especially mammals, is still very limited. This led our group explore biological cognitive consequences rodent model. Following three-week treated with fluorescently-labeled pristine polystyrene young old C57BL/6J mice were assessed using behavioral assays, such as open-field light-dark preference, followed by tissue analyses fluorescent immunohistochemistry, Western blot, qPCR. Data assays suggest short-term both changes well alterations immune markers liver brain tissues. Additionally, we noted differed depending age, indicating possible age-dependent effect. These findings need for further better understand mechanisms which may induce physiological changes.

Language: Английский

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Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo

Particle and Fibre Toxicology, Journal Year: 2023, Volume and Issue: 20(1)

Published: Nov. 22, 2023

Microplastics and nanoplastics (MNPs) are emerging environmental contaminants detected in human samples, have raised concerns regarding their potential risks to health, particularly neurotoxicity. This study aimed investigate the deleterious effects of polystyrene (PS-NPs, 50 nm) understand mechanisms inducing Parkinson's disease (PD)-like neurodegeneration, along with exploring preventive strategies.

Language: Английский

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Micro(nano)plastics in the Human Body: Sources, Occurrences, Fates, and Health Risks

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 5, 2024

The increasing global attention on micro(nano)plastics (MNPs) is a result of their ubiquity in the water, air, soil, and biosphere, exposing humans to MNPs daily basis threatening human health. However, crucial data body, including sources, occurrences, behaviors, health risks, are limited, which greatly impedes any systematic assessment impact body. To further understand effects we must identify existing knowledge gaps that need be immediately addressed provide potential solutions these issues. Herein, examined current literature behaviors body as well risks. Furthermore, identified key resolved comprehensively assess Additionally, complexity lack efficient analytical methods main barriers impeding investigations necessitating development standard unified method. Finally, highlighted for interdisciplinary studies from environmental, biological, medical, chemical, computer, material scientists fill drive research. Considering inevitability occurrence exposure MNPs, more urgently required enhance our understanding negative

Language: Английский

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Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites

EBioMedicine, Journal Year: 2024, Volume and Issue: 103, P. 105118 - 105118

Published: April 13, 2024

BackgroundMicroplastic (MP) pollution has emerged as a significant environmental concern worldwide. While extensive research focused on their presence in marine organisms and ecosystems, potential impact human health, particularly the circulatory system, remains understudied. This project aimed to identify quantify mass concentrations, polymer types, physical properties of MPs thrombi surgically retrieved from both arterial venous systems at three anatomically distinct sites, namely, cerebral arteries brain, coronary heart, deep veins lower extremities. Furthermore, this study investigate association between levels disease severity.MethodsThrombus samples were collected 30 patients who underwent thrombectomy procedures due ischaemic stroke (IS), myocardial infarction (MI), or vein thrombosis (DVT). Pyrolysis–gas chromatography spectrometry (Py-GC/MS) was employed concentrations MPs. Laser direct infrared (LDIR) spectroscopy scanning electron microscopy (SEM) used analyse Demographic clinical information also examined. A rigorous quality control system eliminate contamination.FindingsMPs detected by Py-GC/MS 80% (24/30) obtained with IS, MI, DVT, median 61.75 μg/g, 141.80 69.62 respectively. Among 10 target types MP polymers, polyamide 66 (PA66), polyvinyl chloride (PVC), polyethylene (PE) identified. Further analyses suggested that higher may be associated greater severity (adjusted β = 7.72, 95% CI: 2.01–13.43, p < 0.05). The level D-dimer MP-detected group significantly than MP-undetected (8.3 ± 1.5 μg/L vs 6.6 0.5 μg/L, 0.001). Additionally, LDIR analysis showed PE dominant among 15 identified MPs, accounting for 53.6% all mean diameter 35.6 μm. shapes polymers using SEM found heterogeneous.InterpretationThis presents qualitative quantitative evidence thrombotic diseases through use multimodal detection methods. Higher increased severity. Future larger sample size is urgently needed sources exposure validate observed trends study.FundingThis funded SUMC Scientific Research Initiation Grant (SRIG, No. 009-510858038), Postdoctoral (No. 202205230031-3), 2020 Li Ka Shing Foundation Cross-Disciplinary 2020LKSFG02C).

Language: Английский

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