Heliyon,
Journal Year:
2025,
Volume and Issue:
11(4), P. e42606 - e42606
Published: Feb. 1, 2025
Microplastic
particles
have
become
ubiquitous
in
various
ecosystems
due
to
a
drastic
increase
plastic
use
and
its
consequent
litter.
The
biological
effects
of
these
on
aquatic
fauna
are
well-documented.
However,
the
study
their
accumulation
subsequent
impact
terrestrial
flora
is
initial
stages.
Furthermore,
favorable
surface
provided
by
plastics
lodges
harmful
substances
pathogens
known
cause
varied
human
physiology.
Notably,
entry
into
gastrointestinal
tract
can
result
ailments,
including
dysbiosis
gut
microflora
microbial
biodiversity.
Moreover,
similar
physiological
ailments
been
observed
humans
action
pathogenic
microorganisms.
Therefore,
this
review,
we
aim
explore
relationship
possible
amplification
pathogenesis
ability
provide
surfaces
for
absorption
biofilm
formation
such
Additionally,
there
exists
possibility
carcinogenesis
coexistence
microbes
micro-and
nanoplastics
synergistic
leading
severe
ailments.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(4), P. 1832 - 1841
Published: Jan. 17, 2024
The
massive
production
of
plastics
causes
the
ubiquitous
existence
microplastics
(MPs)
in
biota,
therefore,
posing
exposure
risks
and
potential
health
concerns
to
human
beings.
However,
exact
mechanisms
MPs-induced
toxicities
abnormalities
are
largely
unknown.
In
this
study,
we
developed
a
mouse
model
gavage
polystyrene
(PS
MPs)
for
30
days.
We
found
that
PS
MPs
can
damage
intestinal
barrier,
accumulate
liver
tissue,
cause
injury.
intestine
both
highly
associated
with
bile
acid
(BA)
metabolism.
Indeed,
dysregulate
BA
synthesis
efflux-related
gene
expression
liver,
causing
cholestasis.
Tandemly,
alter
ratio
primary
secondary
feces
by
affecting
composition
flora.
At
last,
mice's
fecal
profile,
which
affects
normal
Taken
together,
present
study
provides
robust
data
on
mechanism
toxicity
disturbance
metabolism
via
4-step
gut-liver
loop.
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
7(1)
Published: Jan. 11, 2025
As
the
production,
usage,
and
disposal
of
plastics
increase,
microplastics
generated—plastic
particles
smaller
than
5
mm—increases,
exacerbating
environmental
pollution.
In
turn,
various
organisms
become
increasingly
exposed
to
contaminated
environments,
potentially
affecting
humans
through
food
chain.
Crucial
findings
from
in
vivo
experiments
indicate
histopathological
changes
caused
by
impact
morphology
physiological
function
organisms.
This
study
describes
induced
across
circulatory,
nervous,
digestive,
respiratory,
reproductive
systems
explains
associated
functional
alterations.
Except
nervous
system,
main
morphological
involve
degenerative
throughout
body,
such
as
apoptosis,
inflammation,
fibrosis.
Most
were
inflammatory
responses
microplastics,
leading
fibrosis
subsequent
impairments.
Various
studies
confirm
that
stimulate
cells,
increased
reactive
oxygen
species
cell
death.
Consequently,
these
impair
related
systemic
functions.
review
highlights
fundamental
organs
cells
due
discusses
limitations
involving
showing
no
changes.
Genes,
Journal Year:
2023,
Volume and Issue:
14(3), P. 590 - 590
Published: Feb. 26, 2023
Plastic
pollution
in
the
world
is
widespread
and
growing.
The
environment
swamped
with
nanoplastics
(<100
nm),
health
consequences
of
these
less
visible
pollutants
are
unknown.
Furthermore,
there
evidence
that
microplastics
can
release
by
digestive
disintegration,
implying
macroplastic
exposure
cause
direct
indirect
disease
via
nanoplastics.
existence
impact
numerous
tissues
from
invertebrates
to
larger
vertebrates
consume
significant
amounts
plastics
were
investigated,
histopathological
techniques
utilized
determine
physiological
reactions
inflammation
plastics.
Nanoplastics
enters
an
organism
through
respiratory
gastro-intestinal
tract
where
they
accumulate
into
liver
blood
circulation
absorption,
or
epidermal
infiltration.
It
stated
macroplastics
damage
directly
at
site
exposure,
whereas
influence
liver,
causing
subsequent
other
organs.
Multi-organ
dysfunction
brought
on
changes,
readily
enter
gut-liver
axis
disturb
gut
microflora.
By
exploring
literature
summarizing
research
has
been
published
date,
this
review
article
reveals
deleterious
effect
mechanisms
pathophysiological
functions
hepatic
system.
Foods,
Journal Year:
2023,
Volume and Issue:
12(16), P. 3043 - 3043
Published: Aug. 14, 2023
The
ongoing
use
of
plastic
polymers
to
manufacture
food
packaging
has
raised
concerns
about
the
presence
nano-
and
microplastics
(NMPs)
in
a
variety
foods.
This
review
provides
most
recent
data
on
NMPs'
migration
from
into
dairy
products.
Also
discussed
are
possible
effects
NMPs
nutrient
digestion,
absorption,
metabolism.
Different
kinds
products,
including
skimmed
milk,
whole
liquid
powder
infant
formula
have
been
found
contain
various
sizes,
shapes,
concentrations.
may
interact
with
proteins,
carbohydrates,
fats
detrimental
impact
how
well
these
nutrients
digested
absorbed
by
body.
gastrointestinal
tract
lipids,
glucose,
iron,
energy
metabolized,
increasing
risk
developing
health
conditions.
In
addition
NMPs,
oligomers
released
material
migrate
foods
simulants,
though
information
regarding
their
effect
human
is
limited.
Viewpoints
potential
directions
for
future
studies
also
presented
this
review.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 6, 2025
Cadmium
(Cd)
and
polystyrene
microplastics
(PS-MPs),
two
ubiquitous
environmental
contaminants,
produce
unique
synergistic
toxicity
when
co-existing.
Key
unanswered
questions
include
specific
effects
on
liver
function
potential
mechanisms.
In
this
study,
C57BL/6
mice
AML12
cells
were
used
to
establish
in
vivo
vitro
models
elucidate
the
of
combined
exposure
PS-MPs
Cd
their
The
results
showed
that
caused
significantly
more
damage
than
alone.
As
observed
by
transmission
electron
microscopy
(TEM),
number
autophagosomes
was
increased
co-treated
group.
addition,
autophagic
flux
assayed
RFP-GFP-LC3,
a
reporter
system
expressing
dual
fluorescent
proteins,
which
an
overwhelming
enhancement
co-exposure
compared
To
further
investigate
involvement
carnitine
palmitoyltransferase1(CPT1)
injury
induced
PS-MPs,
we
co-exposed
Baicalin,
activator
CPT1,
with
Cd,
activation
CPT1
alleviated
impairment
fluxes
changes
lipid
accumulation
associated
protein
levels.
conclusion,
concurrent
resulted
blockage
hepatic
pathway
aggravated
toxic
liver.
Activation
could
alleviate
Cd-induced
autophagy
thus
reducing
injury.
Environmental Toxicology,
Journal Year:
2023,
Volume and Issue:
38(6), P. 1226 - 1238
Published: March 8, 2023
Abstract
Di(2‐ethylhexyl)
phthalate
(DEHP)
is
a
plasticizer
and
an
endocrine
disruptor.
Microplastics
(MPs)
are
pathogenic
small
plastic
particles
abundant
in
the
aqueous
environment.
The
problem
of
residual
hazards
products
worthy
study,
especially
joint
exposure
variety
plastic‐related
to
toxic
effect.
We
used
200
mg/kg
DEHP
10
mg/L
MPs
establish
model
vivo
2
mM
μg/L
AML12
cell
vitro.
In
study
results
showed
that
compared
with
control
group
(NC)
group,
significantly
increased
contents
malondialdehyde
hydrogen
peroxide,
decreased
glutathione
activity
superoxide
dismutase,
total
antioxidant
capacity,
catalase
peroxidase.
level
oxidative
stress
was
further
aggravated
after
combined
exposure.
reactive
oxygen
species
exposed
vitro
higher
than
NC
single
also
confirmed
could
increase
mRNA
protein
levels
apoptosis
markers
necroptosis
there
additive
After
N‐acetylcysteine
treatment
vitro,
above‐mentioned
damage
significantly.
This
provided
reference
for
advocating
reduction
mixed
use
products,
basis
preventing
harm
residues.
