Gut dysbiosis in rheumatic diseases: A systematic review and meta-analysis of 92 observational studies

EBioMedicine, Journal Year: 2022, Volume and Issue: 80, P. 104055 - 104055

Published: May 17, 2022

BackgroundEmerging evidence suggests that dysbiosis in gut microbiota may contribute to the occurrence or development of several rheumatic diseases. Since is potentially modifiable, it has been postulated be a promising preventive therapeutic target for However, current understanding on potential associations between and diseases still inadequate. Therefore, we aimed synthesise accumulating relation diseases.MethodsThe PubMed, Embase Cochrane Library were searched from inception March 11, 2022 include observational studies evaluating Standardised mean difference (SMD) α-diversity indices controls estimated using random-effects model. β-diversity relative abundance microbes summarised qualitatively.FindingsOf included 92 (11,998 participants), 68 provided data α-diversity. Taken together as whole, decreases consistently found (observed species: SMD = −0.36, [95%CI −0.63, −0.09]; Chao1: −0.57, −0.88, −0.26]; Shannon index: −0.33, −0.48, −0.17]; Simpson −0.32, −0.49, −0.14]). when specific examined, only observed rheumatoid arthritis −0.51, −0.78, −0.24]; −0.31, −0.13]; −0.54, −0.08]), systemic lupus erythematosus (Chao1: −1.60, −2.54, −0.66]; −1.08, −0.18]), gout (Simpson −0.64, −1.07, −0.22]) fibromyalgia −0.28, −0.44, −0.11]), whereas an increase was sclerosis (Shannon 1.25, 0.09, 2.41]). Differences with statistical significance reported ankylosing spondylitis IgG4-related Although little disease specificity found, shared alterations depletion anti-inflammatory butyrate-producing microbe (i.e., Faecalibacterium) enrichment pro-inflammatory Streptococcus) arthritis, Sjögren's syndrome erythematosus.InterpretationGut associated diseases, principally non-specific, microbes.FundingNational Natural Science Foundation China (81930071, 81902265, 82072502 U21A20352).

Language: Английский

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The gut ecosystem and immune tolerance

Journal of Autoimmunity, Journal Year: 2023, Volume and Issue: 141, P. 103114 - 103114

Published: Sept. 23, 2023

The gastrointestinal tract is home to the largest microbial population in human body. gut microbiota plays significant roles development of immune system and has a substantial impact on maintenance tolerance beginning early life. These microbes interact with dynamic interdependent manner. They generate signals by presenting vast repertoire antigenic determinants metabolites that influence development, maturation immunological function homeostasis. At same time, both innate adaptive systems are involved modulating stable ecosystem between commensal pathogenic microorganisms. Hence, host work together maintain homeostasis synergistically. In susceptible hosts, disruption such harmonious state can greatly affect health lead various auto-inflammatory autoimmune disorders. this review, we discuss our current understanding interactions immunity an emphasis on: a) important players immunity; b) contribution metabolites; c) effect as well alteration microbiome molecular mechanisms driving autoimmunity diseases.

Language: Английский

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Gut Microbiota and Autoimmune Diseases: Mechanisms, Treatment, Challenges, and Future Recommendations

Current Clinical Microbiology Reports, Journal Year: 2024, Volume and Issue: 11(1), P. 18 - 33

Published: Jan. 16, 2024

Abstract Purpose of Review This review provides an overview the role dysbiosis (imbalanced gut microbiota) in maintenance host homeostasis and immune function summarizes recent evidence connecting microbiota to development autoimmune diseases (ADs) (such as rheumatoid arthritis, type 1 diabetes, systemic lupus erythematosus, multiple sclerosis, spondyloarthritis, irritable bowel syndrome). The potential mechanisms that underlie host-microbiota interaction are also discussed evaluate manipulation a therapeutic approach managing ADs. Additionally, this addresses current challenges microbiota-host research future recommendations. Recent Findings findings suggested pathogenesis ADs appears be multifaceted involving both genetic environmental factors. Dysbiosis or imbalanced has been increasingly identified one main factors can modulate responses contribute Summary New highlighted significance microbial etiology numerous diseases. Understanding relationship between host, however, goes beyond taxonomic concerns, demanding multidisciplinary efforts design new approaches take individual variances into account.

Language: Английский

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Emerging role of gut microbiota in autoimmune diseases

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 3, 2024

Accumulating studies have indicated that the gut microbiota plays a pivotal role in onset of autoimmune diseases by engaging complex interactions with host. This review aims to provide comprehensive overview existing literatures concerning relationship between and diseases, shedding light on interplay microbiota, host immune system. Furthermore, we aim summarize impacts potential mechanisms underlie primarily focusing systemic lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, type 1 diabetes mellitus, ulcerative colitis psoriasis. The present will emphasize clinical significance applications interventions based as innovative adjunctive therapies for diseases.

Language: Английский

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Efficacy and safety of gut microbiota-based therapies in autoimmune and rheumatic diseases: a systematic review and meta-analysis of 80 randomized controlled trials

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 13, 2024

Abstract Background Previous randomized controlled trials (RCTs) suggested that gut microbiota-based therapies may be effective in treating autoimmune diseases, but a systematic summary is lacking. Methods Pubmed, EMbase, Sinomed, and other databases were searched for RCTs related to the treatment of diseases with probiotics from inception June 2022. RevMan 5.4 software was used meta-analysis after 2 investigators independently screened literature, extracted data, assessed risk bias included studies. Results A total 80 14 types disease [celiac sprue, SLE, lupus nephritis (LN), RA, juvenile idiopathic arthritis (JIA), spondyloarthritis, psoriasis, fibromyalgia syndrome, MS, systemic sclerosis, type 1 diabetes mellitus (T1DM), oral lichen planus (OLP), Crohn’s disease, ulcerative colitis] included. The results showed improve symptoms and/or inflammatory factor celiac SLE LN, JIA, PSS, colitis. However, not spondyloarthritis RA. Gut relieve pain effect on impact questionnaire score significant. HbA1c T1DM, its insulin requirement does seem These did increase incidence adverse events. Conclusions several (celiac colitis).

Language: Английский

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Gut Microbiome and Metabolites in Systemic Lupus Erythematosus: Link, Mechanisms and Intervention

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: July 15, 2021

Systemic lupus erythematosus (SLE), often considered the prototype of autoimmune diseases, is characterized by over-activation system with abnormal functions innate and adaptive immune cells production a large number autoantibodies against nuclear components. Given highly complex heterogeneous nature SLE, pathogenesis this disease remains incompletely understood presumed to involve both genetic environmental factors. Currently, disturbance gut microbiota has emerged as novel player involved in SLE. With in-depth research, understanding intestinal bacteria-host interaction SLE much more comprehensive. Recent years have also seen an increase metabolomics studies attempt identify potential biomarkers for diagnosis or activity monitoring. An intricate relationship between microbiome changes metabolic alterations could help explain mechanisms which bacteria play roles Here, we review role dysbiosis aetiology how interact host metabolism axis. A proposed treatment strategy based on (GM) regulation discussed review. Increasing our their function will provide us opportunities develop effective precise diagnostic strategies explore microbiota-based treatments patients lupus.

Language: Английский

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Recent Advances in Our Understanding of the Link between the Intestinal Microbiota and Systemic Lupus Erythematosus

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(19), P. 4871 - 4871

Published: Sept. 30, 2019

Systemic lupus erythematosus (SLE) is an autoimmune disease featuring enhanced expression of type I interferon (IFN) and autoantibody production triggering inflammation of, damage to, multiple organs. Continuing research efforts focus on how gut microbes trigger systemic autoimmunity SLE. The microbial communities mice humans with have been investigated via high-throughput sequencing. Firmicutes-to-Bacteroidetes ratio consistently reduced in SLE patients, regardless ethnicity. relative abundance Lactobacillus differs from the animal model used (MRL/lpr or NZB/W F1 mice). This may indicate that interactions between host, rather than enrichment certain microbes, are especially significant terms development. Enterococcus gallinarum reuteri, both which possible pathobionts, become translocated into tissue if epithelial barrier impaired. then interact host immune systems, activating IFN pathway inducing production. In addition, molecular mimicry critically link microbiome to Gut commensals patients share protein epitopes Ro60 autoantigen. Ruminococcus gnavus strain cross-reacted native DNA, anti-double-stranded DNA antibody response. Expansion R. paralleled increase activity nephritis. Such insights microbiota enhance our understanding pathogenesis will identify biomarkers predicting active disease.

Language: Английский

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Interconnections between the Oral and Gut Microbiomes: Reversal of Microbial Dysbiosis and the Balance between Systemic Health and Disease

Microorganisms, Journal Year: 2021, Volume and Issue: 9(3), P. 496 - 496

Published: Feb. 26, 2021

The human microbiota represents a complex array of microbial species that influence the balance between health and pathology their surrounding environment. These microorganisms impart important biological benefits to host, such as immune regulation resistance pathogen colonization. Dysbiosis communities in gut mouth precede many oral systemic diseases cancer, autoimmune-related conditions, inflammatory states, can involve breakdown innate barriers, dysregulation, pro-inflammatory signaling, molecular mimicry. Emerging evidence suggests periodontitis-associated pathogens translocate distant sites elicit severe local pathologies, which necessitates research into future therapies. Fecal transplantation, probiotics, prebiotics, synbiotics represent current modes treatment reverse dysbiosis through introduction health-related bacterial substrates. Furthermore, emerging field precision medicine has been shown be an effective method modulating host response targeting biomarkers mediators. Although connections microbiome, system, disease are becoming more apparent, interplay innovations modalities will become elucidated continued cross-disciplinary collaboration.

Language: Английский

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Can Gut Microbiota Affect Dry Eye Syndrome?

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(22), P. 8443 - 8443

Published: Nov. 10, 2020

Using metagenomics, continuing evidence has elicited how intestinal microbiota trigger distant autoimmunity. Sjögren’s syndrome (SS) is an autoimmune disease that affects the ocular surface, with frequently unmet therapeutic needs requiring new interventions for dry eye management. Current studies also suggest possible relation of gut microbiota. Herein, we review current knowledge interact immune system in homeostasis as well its influence on rheumatic and diseases, compare their characteristics SS. Both rodent human regarding SS environmental are explored, effects prebiotics probiotics discussed. Recent clinical have commonly observed a correlation between dysbiosis manifestations SS, while portrays normal autoimmune. Moreover, decrease both Firmicutes/Bacteroidetes ratio genus Faecalibacterium most been subjects. The presumable pathways forming “gut dysbiosis–ocular surface–lacrimal gland axis” introduced. This may provide perspectives into link microbiome eye, enhance our understanding pathogenesis be useful development future interventions.

Language: Английский

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The Immunomodulatory Effect of the Gut Microbiota in Kidney Disease

Journal of Immunology Research, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 16

Published: May 15, 2021

The human gut microbiota is a complex cluster composed of 100 trillion microorganisms, which holds symbiotic relationship with the host under normal circumstances. Intestinal flora can facilitate treatment metabolic dysfunctions and interact intestinal tract, could influence tolerance, immunity, sensitivity to inflammation. In recent years, significant interests have evolved on association kidney diseases within academic circle. Abnormal changes in microbiota, known as dysbiosis, affect integrity barrier, resulting bacterial translocation, production, accumulation dysbiotic gut-derived metabolites, such urea, indoxyl sulfate (IS), p-cresyl (PCS). These processes lead abnormal activation immune cells; overproduction antibodies, complexes, inflammatory factors; cell infiltration that directly or indirectly cause damage renal parenchyma. aim this review summarize role development progression several diseases, lupus nephritis, chronic disease, diabetic nephropathy, ischemia-reperfusion injury. Further research these mechanisms should provide insights into therapeutic potential regulating intervening related molecular targets for abovementioned nephropathy.

Language: Английский

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