Current Opinion in Pharmacology, Journal Year: 2024, Volume and Issue: 75, P. 102431 - 102431
Published: Jan. 25, 2024
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114620 - 114620
Published: March 31, 2023
There is emerging evidence that microbiota and its metabolites play an important role in helath diseases. In this regard, gut has been found as a crucial component influences immune responses well immune-related disorders such autoimmune Gut bacterial dysbiosis shown to cause disease altered metabolite synthesis, leading immunological metabolic dysregulation. Of note, the produce short-chain fatty acids (SCFAs) acetate, butyrate, propionate, remodeling these linked pathophysiology of number type 1 diabetes, multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis, celiac systemic lupus erythematosus. review, we will address most recent findings from noteworthy studies investigating impact SCFAs on various
Language: Английский
Citations
48
Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 329, P. 64 - 71
Published: Feb. 25, 2023
Several studies have linked gut microbiota to human brain activity. This study used Mendelian randomization (MR) investigate the causal relationship between microbes and delirium.MR was select SNPs from large-scale GWAS summary data on 211 taxa delirium. Inverse variance weighting (IVW), weighted median, MR-Egger methods were for statistical analyses. Outliers assessed using leave-one-out method. To avoid horizontal pleiotropy, we performed MR-PRESSO intercept tests. Cochran's Q I2 values IVW assess heterogeneity.IVW suggested that genetic prediction of family Desulfovibrionaceae (1.784 (1.267-2.512), P = 0.001), order Desulfovibrionales (1.501 (1.058-2.128), 0.023), genus Candidatus Soleaferrea (1.322 (1.052-1.659), 0.016) increased risk delirium, but Oxalobacteraceae (0.841 (0.722-0.981), 0.027), genera Holdemania (0.766 (0.620-0.946), 0.013), Ruminococcus gnavus (0.806 (0.661-0.982), 0.033), Eggerthella (0.815 (0.667-0.997), 0.047) reduced delirium.(1) Limited sample size, (2) inability interactions, (3) limited European populations.Our results suggest presence microbial Desulfovibrionaceae, Desulfovibrionales, whereas family, Holdemania, gnavus, decreased However, potential probiotic interventions in prevention perioperative delirium should be emphasized.
Language: Английский
Citations
47
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: May 3, 2024
Accumulating studies have indicated that the gut microbiota plays a pivotal role in onset of autoimmune diseases by engaging complex interactions with host. This review aims to provide comprehensive overview existing literatures concerning relationship between and diseases, shedding light on interplay microbiota, host immune system. Furthermore, we aim summarize impacts potential mechanisms underlie primarily focusing systemic lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, type 1 diabetes mellitus, ulcerative colitis psoriasis. The present will emphasize clinical significance applications interventions based as innovative adjunctive therapies for diseases.
Language: Английский
Citations
22
International Ophthalmology, Journal Year: 2022, Volume and Issue: 42(10), P. 3253 - 3272
Published: June 9, 2022
Language: Английский
Citations
43
The Ocular Surface, Journal Year: 2023, Volume and Issue: 29, P. 175 - 219
Published: May 4, 2023
Language: Английский
Citations
38
The Ocular Surface, Journal Year: 2023, Volume and Issue: 29, P. 226 - 271
Published: April 25, 2023
Language: Английский
Citations
27
Progress in Retinal and Eye Research, Journal Year: 2024, Volume and Issue: 100, P. 101250 - 101250
Published: March 8, 2024
Changes in the bacterial flora gut, also described as gut microbiota, are readily acknowledged to be associated with several systemic diseases, especially those an inflammatory, neuronal, psychological or hormonal factor involved pathogenesis and/or perception of disease. Maintaining ocular surface homeostasis is based on all these four factors, and there accumulating evidence literature relationship between microbiota diseases. The mechanisms mostly interconnected due interaction central peripheral neuronal networks, inflammatory effectors system. A better understanding influence maintenance homeostasis, onset persistence disorders could bring new insights help elucidate epidemiology pathology dynamics health Revealing exact nature associations paramount importance for developing a holistic approach using highly promising therapeutic strategies targeting
Language: Английский
Citations
13
Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13
Published: Aug. 9, 2023
Introduction Recently the role of gut microbial dysbiosis in many ocular disorders, including but not limited to uveitis, age-related macular degeneration (AMD), diabetic retinopathy (DR), dry eye, keratitis and orbitopathy is a hot research topic field. Targeting microbiota treat these diseases has become an unstoppable trend. Bibliometric study visualization analysis have essential methods for literature medical We aim depict this area's hotspots future directions by bibliometric software methods. Methods search all related publications from Web Science Core Collection. Then, CiteSpace was applied analyze visualize country distributions, dual-map overlay journals, keyword bursts, co-cited references. VOSviewer employed identify authors, journals display co-occurrence networks. Results A total 284 relevant were identified 2009 2023. The number studies been small first five years grown steadily since 2016. These completed 1,376 authors 41 countries worldwide, with United States lead. Lin P published most papers while Horai R author. top journal are both Investigative Ophthalmology & Visual Science. In network, except microbiota, inflammation becomes highest frequency. Co-citation analyses reveal that involved common immune- inflammation-mediated eye diseases, retinopathy, degeneration, Graves' orbitopathy, microbiomes no longer bacterial populations. Therapeutic strategies target such as probiotics, healthy diet patterns, fecal transplantation, effective critical research. Conclusions conclusion, displays developmental involvement pathogenesis treatment some diseases. It provides overview field's dynamic evolution structural relationships.
Language: Английский
Citations
17
Experimental Eye Research, Journal Year: 2024, Volume and Issue: 240, P. 109788 - 109788
Published: Jan. 11, 2024
Language: Английский
Citations
7
Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: May 10, 2024
The intricate interplay between the gut microbiota and ocular health has surpassed conventional medical beliefs, fundamentally reshaping our understanding of organ interconnectivity. This review investigates into relationship microbiota-derived metabolites their consequential impact on disease pathogenesis. By examining role specific metabolites, such as short-chain fatty acids (SCFAs) like butyrate bile (BAs), herein we elucidate significant contributions to pathologies, thought-provoking traditional belief sterility, particularly in field ophthalmology. Highlighting dynamic nature its profound influence health, this underlines necessity comprehending complex workings gut-eye axis, an emerging science ready for further exploration scrutiny. While acknowledging therapeutic promise manipulating microbiome available literature advocates a targeted, precise approach. Instead broad interventions, it emphasizes potential exploiting microbiome-related focused strategy. targeted approach compared precision tool rather than broad-spectrum solution, aims explore applications context various retinal diseases. proposing nuanced strategy at microbial suggests that addressing deficiencies or imbalances through might yield expedited pronounced outcomes systemic extending eye. holds bypassing irregularity associated with microbes themselves, paving more efficient pathway toward desired optimizing implications
Language: Английский
Citations
6