An update on the regulatory mechanisms of NLRP3 inflammasome activation

Cellular and Molecular Immunology, Journal Year: 2021, Volume and Issue: 18(5), P. 1141 - 1160

Published: April 13, 2021

Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is a multiprotein complex involved in the release of mature interleukin-1β triggering pyroptosis, which paramount importance variety physiological pathological conditions. Over past decade, considerable advances have been made elucidating molecular mechanisms underlying priming/licensing (Signal 1) assembly 2) NLRP3 activation. Recently, number studies indicated that step regulated by complicated at both transcriptional posttranslational levels. In this review, we discuss current understanding mechanistic details activation with particular emphasis on protein-protein interactions, modifications, spatiotemporal regulation machinery. We also present detailed summary multiple positive and/or negative regulatory pathways providing upstream signals culminate assembly. A better will provide opportunities for development methods prevention treatment inflammasome-related diseases.

Language: Английский

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Kinase inhibition in autoimmunity and inflammation

Nature Reviews Drug Discovery, Journal Year: 2020, Volume and Issue: 20(1), P. 39 - 63

Published: Oct. 19, 2020

Language: Английский

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Ankylosing spondylitis: an autoimmune or autoinflammatory disease?

Nature Reviews Rheumatology, Journal Year: 2021, Volume and Issue: 17(7), P. 387 - 404

Published: June 10, 2021

Language: Английский

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Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases

Nature Reviews Rheumatology, Journal Year: 2021, Volume and Issue: 17(10), P. 585 - 595

Published: Aug. 2, 2021

Language: Английский

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COVID-19 and the clinical course of rheumatic manifestations

Clinical Rheumatology, Journal Year: 2021, Volume and Issue: 40(7), P. 2611 - 2619

Published: March 17, 2021

Language: Английский

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Pyroptosis and Its Role in Autoimmune Disease: A Potential Therapeutic Target

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: May 25, 2022

Autoimmune diseases are a group of heterogeneous with diverse clinical manifestations that can be divided into systemic and organ-specific. The common etiology autoimmune is the destruction immune tolerance production autoantibodies, which attack specific tissues and/or organs in body. pathogenesis complicated, genetic, environmental, infectious, even psychological factors work together to cause aberrant innate adaptive responses. Although exact mechanisms unclear, recently, excessive exacerbation pyroptosis, as bond between immunity, has been proven play crucial role development disease. Pyroptosis characterized by pore formation on cell membranes, well rupture excretion intracellular contents pro-inflammatory cytokines, such IL-1β IL-18. This overactive inflammatory programmed death disrupts system homeostasis promotes autoimmunity. review examines molecular structure classical inflammasomes, including NLRP3, AIM2, P2X7-NLRP3, switches their regulation mechanisms. sophisticated pyroptosis pathways, canonical caspase-1-mediated pathway, noncanonical caspase-4/5/11-mediated emerging caspase-3-mediated caspase-independent also described. We highlight recent advances diseases, lupus erythematosus, rheumatoid arthritis, bowel disease, Sjögren’s syndrome dermatomyositis, attempt identify its potential advantages therapeutic target or prognostic marker these diseases.

Language: Английский

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The role of inflammation in autoimmune disease: a therapeutic target

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 4, 2023

Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence increasing year by year. AIDs produced the system’s misidentification of self-antigens, seemingly caused excessive function, but in fact they result reduced accuracy due to decline system which cannot clearly identify foreign invaders thus issuing false attacks, eventually leading disease. The occurrence is often accompanied emergence inflammation, inflammatory mediators (inflammatory factors, inflammasomes) play an important role pathogenesis AIDs, mediate process affecting innate cells (such as macrophages) adaptive T B cells), ultimately promote autoimmune responses, so targeting mediators/pathways one emerging treatment strategies AIDs. This review will briefly describe inflammation different give a rough introduction inhibitors hoping have reference significance for subsequent options

Language: Английский

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Isoliquiritigenin, a potential therapeutic agent for treatment of inflammation-associated diseases

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 318, P. 117059 - 117059

Published: Aug. 20, 2023

Language: Английский

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The diagnostic role of the systemic inflammation index in patients with immunological diseases: a systematic review and meta-analysis

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 29, 2024

Abstract The identification of novel, easily measurable biomarkers inflammation might enhance the diagnosis and management immunological diseases (IDs). We conducted a systematic review meta-analysis to investigate an emerging biomarker derived from full blood count, systemic index (SII), in patients with IDs healthy controls. searched Scopus, PubMed, Web Science inception 12 December 2023 for relevant articles evaluated risk bias certainty evidence using Joanna Briggs Checklist Grades Recommendation, Assessment, Development, Evaluation Working Group system, respectively. In 16 eligible studies, had significantly higher SII when compared controls (standard mean difference, SMD = 1.08, 95% CI 0.75 1.41, p < 0.001; I 2 96.2%, moderate evidence). pooled area under curve (AUC) diagnostic accuracy was 0.85 (95% 0.82–0.88). subgroup analysis, effect size significant across different types ID, barring lupus erythematosus ( 0.20). further analyses, ID active disease vs. those remission (SMD 0.81, 0.34–1.27, 93.6%, AUC 0.74 0.70–0.78). Our study suggests that can effectively discriminate between subjects without disease. Prospective studies are warranted determine whether routine practice. (PROSPERO registration number: CRD42023493142).

Language: Английский

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Deciphering the relationship between temperature and immunity

Discovery Immunology, Journal Year: 2024, Volume and Issue: 3(1)

Published: Jan. 1, 2024

Fever is a hallmark symptom of disease across the animal kingdom. Yet, despite evidence linking temperature fluctuation and immune response, much remains to be discovered about molecular mechanisms governing these interactions. In patients with rheumatoid arthritis, for instance, it clinically accepted that joint can predict progression. But was only recently demonstrated mitochondria stimulated T cells rise an extreme 50°C, potentially indicating cellular source localized 'fevers'. A challenge dissecting bidirectional interplay between immunity. Heat shock response found in virtually all organisms, activating protective pathways when are exposed elevated temperatures. However, threshold activates vary within same organism, human cells, particular, demonstrating differential sensitivity heat. Such inter-cellular variation may relevant given small but significant differences seen tissues, ages, sexes. Greater understanding how such perturbations mediate responses provide new explanations persistent questions as sex disparity prevalence. Notably, prevalence severity many maladies rising climate change, suggesting fluctuations interact on multiple levels. As global temperatures rising, our body falling, regarding temperature-immune interactions increasingly critical. Here, we review this aspect environmental better understand temperature's role subsequent risk disease.

Language: Английский

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