Parents’ and Guardians’ Willingness to Vaccinate Their Children against COVID-19: A Systematic Review and Meta-Analysis

Vaccines, Journal Year: 2022, Volume and Issue: 10(2), P. 179 - 179

Published: Jan. 24, 2022

COVID-19 vaccination for children is crucial to achieve herd immunity. This the first systematic review and meta-analysis estimate parents’ guardians’ willingness vaccinate their against identify determinants of intention. Systematic research was performed on two databases (PubMed EMBASE) from inception 6 November 2021. Acceptance rates were pooled by use a random-effects model all predictors vaccine acceptance identified according health belief (HBM) framework. analysis registered with PROSPERO (CRD42021292326) reported in compliance PRISMA guidelines. Of 452 records, 29 eligible studies included (N = 68,327 participants). The estimated worldwide rate 61.40% (95% CI: 53.56–68.69%, I2 99.3%), ranging 21.6% 91.4% across countries regions. In determinant assessment, age parents guardians, access scientific information recommendations, routine influenza behavior, guardians themselves potentially significant willingness. Given limited quality quantity articles, future rigorous design will be necessary confirmation our findings.

Language: Английский

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COVID-19 vaccine and booster hesitation around the world: A literature review

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 9

Published: Jan. 12, 2023

The development of COVID-19 vaccines has helped limit the extent pandemic, which over past 2 years claimed lived millions people. Moderna and Pfizer were first to be manufactured using mRNA technology. Since then, other manufacturers have built their own utilize adenovirus vector, whole inactivated coronavirus, protein subunit methods. Given continued mutation SARS-CoV-2 virus, a booster vaccine offers additional protection for citizens, especially those with comorbid conditions. However, uptake faced hurdles. This literature review aims analyze acceptance among different populations throughout world. Keywords searched include “COVID-19 rates OR rates,” hesitancy,” “reasons against vaccine,” acceptance” (for each country). Research articles indexed in PubMed, University Illinois Urbana-Champaign Library, Google Scholar included. Despite proven effectiveness booster, hesitancy is still causing suboptimal compliance primary thus slowing down control pandemic. Reasons differ by country affected misinformation, political circumstances, cultural values. Among most common reasons found are distrust government, lack safety information, fear side effects. Uptake also been delayed low middle income countries due resource allocation as result, these fallen behind vaccination benchmarks. future unknown, but mandates doses possibility. Determining ethical impact that policies could will allow best implementation.

Language: Английский

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SARS-CoV-2 Variants: Genetic Insights, Epidemiological Tracking, and Implications for Vaccine Strategies

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1263 - 1263

Published: Jan. 31, 2025

The emergence of SARS-CoV-2 variants has significantly impacted the global response to COVID-19 pandemic. This review examines genetic diversity variants, their roles in epidemiological tracking, and influence on viral fitness. Variants concern (VOCs) such as Alpha, Beta, Gamma, Delta, Omicron have demonstrated increased transmissibility, altered pathogenicity, potential resistance neutralizing antibodies. Epidemiological tracking these is crucial for understanding spread, informing public health interventions, guiding vaccine development. also explores how specific mutations spike protein other genomic regions contribute fitness, affecting replication efficiency, immune escape, transmission dynamics. By integrating surveillance data with clinical findings, this provides a comprehensive overview ongoing evolution its implications strategies new

Language: Английский

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Trust in Science as a Possible Mediator between Different Antecedents and COVID-19 Booster Vaccination Intention: An Integration of Health Belief Model (HBM) and Theory of Planned Behavior (TPB)

Vaccines, Journal Year: 2022, Volume and Issue: 10(7), P. 1099 - 1099

Published: July 8, 2022

As the literature highlights, many health behavior theories try to explain both social and psychological variables influencing an individual's behavior. This study integrates insights relative antecedents of getting vaccinated from theories, particularly including belief model (HBM), theory planned (TPB), different socio-demographic factors. Furthermore, we considered possible mechanism impact distrust in science on individuals' hesitance resistance taking up SARS-CoV-2 vaccination subjects living Italy. A correlational 1095 enrolled when national campaign for third dose was launched. questionnaire used measure: Italian Risk Perception; subjective norm; trust science, vaccine; fear COVID-19; perceived knowledge about SARS-CoV-2; booster intention. Principal results show that: (i) positive relationship provided by HBM between perceptions risk (vulnerability severity) intention have vaccine, through (ii) norms intention; (iii) that plays a crucial role predicting Finally, indications COVID-19, full mediation relationships determinants TPA HBM, In conclusion, (not) get requires consideration plethora socio-psychological However, overall, appears be key determinant Additional strategies promoting healthy are needed.

Language: Английский

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Assessing COVID-19 Booster Hesitancy and Its Correlates: An Early Evidence from India

Vaccines, Journal Year: 2022, Volume and Issue: 10(7), P. 1048 - 1048

Published: June 30, 2022

The emergence of SARS-CoV-2 mutants, waning immunity, and breakthrough infections prompted the use booster doses COVID-19 vaccine to fight against pandemic. India started in January 2022 it is critical determine intention dose uptake its correlates. Therefore, current cross-sectional study aimed investigate acceptability associated predictors among Indian population. A convenience sampling technique was utilized recruit a sample 687 residents. 55-item psychometric validated survey tool used assess acceptability, literacy confidence. Univariate, bivariate, multivariate statistical methods were analyze data. Over 50% participants reported their willingness take dose. Among group not willing (n = 303, 44.1%), significantly larger proportion respondents unvaccinated with primary series (12.2% vs. 5.2%, p < 0.001), had an annual income below 2.96 lacs/annum (52.8% 33.1, residents rural areas (38.0% 23.2%, living vulnerable individuals (78.5% 65.2%, 0.001) did have family/friends who tested positive for (54.6% 35.1%, 0.001). Demographic, variables multi-theory model subscales predict initiation hesitant statistically significant, R2 0.561, F (26, 244) 11.978, 0.001; adjusted 0.514. Findings this highlight need develop evidence-based interventions promote uptake, particularly hard-to-reach communities developing countries.

Language: Английский

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First COVID-19 Booster Dose in the General Population: A Systematic Review and Meta-Analysis of Willingness and Its Predictors

Vaccines, Journal Year: 2022, Volume and Issue: 10(7), P. 1097 - 1097

Published: July 8, 2022

The emergence of breakthrough infections and new highly contagious variants SARS-CoV-2 threaten the immunization in individuals who had completed primary COVID-19 vaccination. This systematic review meta-analysis investigated, for first time, acceptance booster dose its associated factors among fully vaccinated individuals. We followed PRISMA guidelines. searched Scopus, Web Science, Medline, PubMed, ProQuest, CINAHL medrxiv from inception to 21 May 2022. found 14 studies including 104,047 prevalence intend accept a was 79.0%, while unsure 12.6%, that refuse 14.3%. main predictors willingness were older age, flu vaccination previous season, confidence most important reasons decline adverse reactions discomfort experienced after vaccine doses concerns serious doses. Considering burden COVID-19, high rate could be critical controlling pandemic. Our findings are innovative help policymakers design implement specific programs order decrease hesitancy.

Language: Английский

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Evolution and implications of SARS-CoV-2 variants in the post-pandemic era

Deleted Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: June 28, 2024

Abstract SARS-CoV-2, the cause of COVID-19 pandemic, has introduced a challenging era characterized by persistent emergence subvariants. Even after World Health Organization announced end virus continues to evolve, posing significant challenges public health responses. This comprehensive review examines multifaceted impacts these subvariants, emphasizing their significance across diverse dimensions. SARS-CoV-2 genetic variability, especially at spike protein region, which given rise Variants Concern, including Beta, Delta, Gamma, Alpha, and highly mutable Omicron, differently exhibit varying levels immune evasion, disease severity, transmissibility. Subvariants within Omicron lineage, BA.1, BA.2, BA.3, others, further complicate landscape with distinct signatures infectivity levels. The extend diagnostic techniques, treatment strategies, vaccine effectiveness, underscoring need for response preventive measures, genomic surveillance, vaccination campaigns. Sustaining interventions is critical, necessitating long-term strategies considering socio-political factors, community involvement, continuous adaptation healthcare approaches, robust monitoring, sustainable effectively combat virus's ever-changing landscape.

Language: Английский

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Single-cell transcriptome atlas of peripheral immune features to Omicron breakthrough infection under booster vaccination strategies

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

The high percentage of Omicron breakthrough infection in vaccinees is an emerging problem, which we have a limited understanding the phenomenon. We performed single-cell transcriptome coupled with T-cell/B-cell receptor (TCR/BCR) sequencing 15 peripheral blood mononuclear cell (PBMC) samples from and naïve booster vaccination. found that after infection, multiple clusters showed activation type I IFN pathway widespread expression Interferon-stimulated genes (ISGs); T B lymphocytes exhibited antiviral proinflammatory-related differentiation features pseudo-time trajectories; large TCR clonal expansions were concentrated effector CD8 cells, BCRs preference for IGHV3. In addition, myeloid cells BA.5.2 fourth dose aerosolized Ad5-nCoV characterized by enhanced proliferation, chemotactic migration, antigen presentation. Collectively, our study informs comprehensive understandings immune characterization revealing positive potential induced doses vaccine possible "trained immunity" phenomenon Ad5-nCoV, providing basis selection vaccination strategies.

Language: Английский

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MDR Pumps as Crossroads of Resistance: Antibiotics and Bacteriophages

Antibiotics, Journal Year: 2022, Volume and Issue: 11(6), P. 734 - 734

Published: May 30, 2022

At present, antibiotic resistance represents a global problem in modern medicine. In the near future, humanity may face situation where medicine will be powerless against resistant bacteria and post-antibiotic era come. The development of new antibiotics is either very expensive or ineffective due to rapidly developing bacterial resistance. need develop alternative approaches treatment infections, such as phage therapy, beyond doubt. cornerstone defense are multidrug (MDR) pumps, which involved resistance, toxin export, biofilm, persister cell formation. MDR pumps primary non-specific antibiotics, while drug target modification, inactivation, switching, sequestration second, specific line their defense. All have bacteriophages evolved along with them use bacteria’s for bind penetrate into cells. study understanding mechanisms contribution overall sensitivity allow us seriously delay onset even prevent it altogether phage-antibiotic synergy.

Language: Английский

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COVID-19 Vaccine Uptake among Healthcare Workers: A Systematic Review and Meta-Analysis

Vaccines, Journal Year: 2022, Volume and Issue: 10(10), P. 1637 - 1637

Published: Sept. 29, 2022

The vaccine-induced immunity of healthcare workers (HCWs) is crucial to controlling the COVID-19 pandemic. Therefore, we conducted a systematic review and meta-analysis assess vaccine uptake among HCWs worldwide identify predictors vaccination. We searched Scopus, Web Science, Medline, PubMed, ProQuest, CINAHL, medRxiv up 25 August 2022. applied Preferred Reporting Items for Systematic Reviews Meta-Analysis guidelines. found studies including 491,624 vaccinated HCWs, while full sample included 555,561 HCWs. overall proportion was 77.3%. Vaccine that were in North America (85.6%) higher than Asia (79.5%), Europe (72.8%), Africa (65.6%). prevalence 83.6% 77.4% physicians nurses, respectively. Older age, white race, physicians’ profession, seasonal influenza vaccine, direct patient care, confidence safety effectiveness positive uptake, history SARS-CoV-2 infection negative predictor. Deep understanding factors influence HCWs’ decisions receive critical implementing tailored communication strategies who are at risk not getting vaccinated.

Language: Английский

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