Sensors & Diagnostics, Journal Year: 2023, Volume and Issue: 2(3), P. 632 - 639
Published: Jan. 1, 2023
A CRISPR–Cas13a-powered autocatalytic cleavage circuit (CRISPR-ACC) for ultrasensitive and specific detection of a circadian clock gene was developed.
Language: Английский
Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)
Published: March 4, 2022
The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a wide variety of processes including sleep-wake cycles, eating-fasting and activity-rest coordinating the behavior physiology all organs for whole-body homeostasis. Acute disruption may lead to transient discomfort, whereas long-term irregular will result in dysfunction organism, therefore increasing risks numerous diseases especially cancers. Indeed, both epidemiological experimental evidence has demonstrated intrinsic link between dysregulated cancer. Accordingly, rapidly understanding molecular mechanisms rhythms opening new options cancer therapy, possibly by modulating clock. In this review, we first describe general regulators their functions on addition, provide insights into underlying how several types (including sleep-wake, eating-fasting, activity-rest) can drive progression, which expand our development from clock perspective. Moreover, also summarize potential applications treatment, optional therapeutic strategy patients.
Language: Английский
Citations
91
Journal of Cellular Physiology, Journal Year: 2022, Volume and Issue: 237(8), P. 3239 - 3256
Published: June 13, 2022
Abstract The circadian system is responsible for internal functions and regulation of the organism according to environmental cues (zeitgebers). Circadian rhythm dysregulation or chronodisruption has been associated with several diseases, from mental autoimmune life quality change. Following this, some therapies have developed correct misalignments, such as light therapy chronobiotics. In this manuscript, we describe circadian‐related diseases so far investigated, studies reporting relevant data on topic, evidencing relationship, are included. Despite actual limitations in published work, there clear evidence correlation between disease origin/development, and, way, clock‐related emerge great progress clinical field. Future improvements interventions can lead development successful chronotherapy strategies, deeply contributing enhanced therapeutic outcomes.
Language: Английский
Citations
58
Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 91, P. 99 - 109
Published: March 7, 2023
The circadian rhythm is regulated by an intrinsic time-tracking system, composed both of a central and peripheral clock, which influences the cycles activities sleep individual over 24 h. At molecular level, begins when two basic helix-loop-helix/Per-ARNT-SIM (bHLH-PAS) proteins, BMAL-1 CLOCK, interact with each other to produce BMAL-1/CLOCK heterodimers in cytoplasm. target genes encode for repressor components cryptochrome (Cry1 Cry2) Period proteins (Per1, Per2 Per3). It has been recently demonstrated that disruption associated increased risk developing obesity obesity-related diseases. In addition, it plays key role tumorigenesis. Further, association between disruptions incidence progression several types cancer (e.g., breast, prostate, colorectal thyroid cancer) found. As perturbation adverse metabolic consequences obesity) at same time tumor promoter functions, this manuscript aim report how aberrant rhythms affect development prognosis different cancers (breast, colon rectal focusing on human studies aspects.
Language: Английский
Citations
34
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(3), P. 188900 - 188900
Published: April 25, 2023
The molecular machinery of the circadian clock regulates expression many genes and processes in organism, allowing adaptation cellular activities to daily light-dark cycles. Disruption rhythm can lead various pathologies, including cancer. Thus, disturbance normal at both genetic environmental levels has been described as an independent risk factor for In addition, researchers have proposed that may a tissue-dependent and/or context-dependent role tumorigenesis function tumor suppressors oncogenes. Finally, core trigger or least be involved different hallmarks Hence, expanding knowledge basis would helpful identify new prognostic markers potential therapeutic targets.
Language: Английский
Citations
25
Frontiers in Network Physiology, Journal Year: 2021, Volume and Issue: 1
Published: Oct. 12, 2021
The circadian clock in mammals regulates the sleep/wake cycle and many associated behavioral physiological processes. cellular mechanism involves a transcriptional negative feedback loop that gives rise to rhythms gene expression with an approximately 24-h periodicity. To maintain system robustness, clocks throughout body must be synchronized their functions coordinated. In mammals, master is located suprachiasmatic nucleus (SCN) of hypothalamus. SCN entrained light/dark through photic signal transduction subsequent induction core expression. turn relays time-of-day information peripheral tissues. While highly responsive cues, are more sensitive non-photic resetting cues such as nutrients, temperature, neuroendocrine hormones. For example, feeding/fasting physical activity can entrain signaling pathways regulation genes proteins. As such, timing food intake matters. ideal world, cycles cycle. However, asynchronous environmental those experienced by shift workers frequent travelers, often lead misalignment between clocks. Emerging evidence suggests resulting disruption various diseases chronic conditions cause further desynchrony accelerate disease progression. this review, we discuss how sleep, nutrition, synchronize chronomedicine may offer novel strategies for intervention.
Language: Английский
Citations
45
International Journal of Tryptophan Research, Journal Year: 2023, Volume and Issue: 16
Published: Jan. 1, 2023
The Aryl hydrocarbon receptor (AhR) is a xenobiotic and endobiotic receptor, which regulates many cellular processes from contaminant metabolism to immunomodulation. Consequently, it also involved in pathophysiological pathways now represents potential therapeutical target. In this review, we will highlight the ancestral function of protein together with an illustration its ligand’s battery, emphasizing different responses triggered by these high diverse molecules. Among them, several members kynurenine pathway (one key process tryptophan catabolism) are AhR agonists subsequently regulatory functions. We finally display interplay between Tryptophan (Trp) catabolism dysregulation metabolic drawing hypothesis on involvement cancer-related processes.
Language: Английский
Citations
17
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 30, 2024
Breast cancer (BC) is one of the most common and fatal malignancies among women worldwide. Circadian rhythms have emerged in recent studies as being involved pathogenesis breast cancer. In this paper, we reviewed molecular mechanisms by which dysregulation circadian genes impacts development BC, focusing on critical clock genes, brain muscle ARNT-like protein 1 (BMAL1) locomotor output cycles kaput (CLOCK). We discussed how rhythm disruption (CRD) changes tumor microenvironment (TME), immune responses, inflammation, angiogenesis. The CRD compromises surveillance features activities effectors, including CD8+ T cells tumor-associated macrophages, that are important an effective anti-tumor response. Meanwhile, review, discuss bidirectional interactions: age rhythms, aging further increases risk through reduced vasoactive intestinal polypeptide (VIP), affecting suprachiasmatic nucleus (SCN) synchronization, ability to repair damaged DNA, weakened immunity. These complex interplays open new avenues toward targeted therapies combination drugs with chronotherapy potentiate response while reducing progression for better outcomes. This review tries cover broad area emerging knowledge tumor-immune nexus affected
Language: Английский
Citations
6
Trends in Cell Biology, Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 1, 2024
Language: Английский
Citations
5
Chronobiology International, Journal Year: 2024, Volume and Issue: 41(6), P. 888 - 903
Published: June 2, 2024
This review highlights recent findings on biological rhythms and discusses their implications for the management production of domestic animals. Biological provide temporal coordination between organs tissues in order to anticipate environmental changes, orchestrating biochemical, physiological behavioural processes as right process may occur at time. allows animals adapt internal functions, such sleep-wake cycles, body temperature, hormone secretion, food intake regulation physical performance stimuli that constantly change. The study evaluation various parameters assessment welfare status Alteration represents an imbalance state homeostasis can be found different conditions.
Language: Английский
Citations
5
Aging and Disease, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Circadian rhythm is a self-regulating 24-hour system that synchronizes with the day and night cycle in organisms. The regulation of this controlled by clock genes, which function to harmoniously express molecular levels facilitate orderly coordination various cellular processes, such as sleep, metabolism, endocrine function, cell proliferation immunity. root cause tumorigenesis body loses its normal growth at genetic level. Long-term disruptions circadian rhythms caused factors shift work, jet lag, unstable sleep patterns can impact health, leading health problems, including cancer. controls most functions related cancer progression, has significant on ability immune cells detect promote their clearance crucial implication for future tumor immunotherapy. This article aims review crosstalk between dysregulation tumorigenesis, response. Additionally, we discuss role disruption therapy, highlighting potential optimize treatment timing improve therapeutic outcomes.
Language: Английский
Citations
5