Breast cancer: pathogenesis and treatments

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 18, 2025

Abstract Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes malignancy-related deaths in women. The increasingly nuanced molecular subtypes breast cancer have enhanced comprehension precision treatment this disease. mechanisms tumorigenesis progression been central to scientific research, with investigations spanning various perspectives such as tumor stemness, intra-tumoral microbiota, circadian rhythms. Technological advancements, particularly those integrated artificial intelligence, significantly improved accuracy detection diagnosis. emergence novel therapeutic concepts drugs represents a paradigm shift towards personalized medicine. Evidence suggests that optimal diagnosis models tailored individual patient risk expected are crucial, supporting era oncology for cancer. Despite rapid advancements increasing emphasis on clinical comprehensive update summary panoramic knowledge related disease needed. In review, we provide thorough overview global status including its epidemiology, factors, pathophysiology, subtyping. Additionally, elaborate latest research into contributing progression, emerging strategies, long-term management. This review offers valuable insights Cancer Research, thereby facilitating future progress both basic application.

Language: Английский

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The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 99, P. 24 - 44

Published: Feb. 1, 2024

Autophagy, a self-degradative process vital for cellular homeostasis, plays significant role in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex interplay between autophagy, obesity, cancer development, with specific emphasis on how obesity-driven changes affect regulation of autophagy subsequent implications risk. The burgeoning epidemic obesity underscores relevance this research, particularly given established links various cancers. Our exploration delves into hormonal influence, notably INS (insulin) LEP (leptin), interactions. Further, we draw attention latest findings molecular factors linking cancer, including changes, altered metabolism, secretory autophagy. We posit that targeting modulation may offer potent therapeutic approach obesity-associated pointing promising advancements nanocarrier-based targeted therapies modulation. However, also recognize challenges inherent these approaches, concerning their precision, control, dual roles can play cancer. Future research directions include identifying novel biomarkers, refining therapies, harmonizing approaches precision medicine principles, thereby contributing more personalized, effective treatment paradigm obesity-mediated

Language: Английский

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The Relationship between Circadian Rhythm and Cancer Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5846 - 5846

Published: May 28, 2024

The circadian clock regulates biological cycles across species and is crucial for physiological activities biochemical reactions, including cancer onset development. interplay between the rhythm involves regulating cell division, DNA repair, immune function, hormonal balance, potential chronotherapy. This highlights importance of maintaining a healthy prevention treatment. article investigates complex relationship cancer, exploring how disruptions to internal may contribute tumorigenesis influence progression. Numerous databases are utilized conduct searches articles, such as NCBI, MEDLINE, Scopus. keywords used throughout academic archives “circadian rhythm”, ”cancer”, ”circadian clock”. Maintaining cycle prioritizing sleep habits minimizing disruptions, consistent schedules, reduced artificial light exposure, meal timing adjustments. Dysregulation gene can cause tumor growth, leading need regulate better treatment outcomes. components significantly impact cellular responses damage, influencing Understanding rhythm’s role in diseases their therapeutic targets essential treating preventing cancer. Disruptions promote abnormal development metastasis, potentially due system imbalances fluctuations.

Language: Английский

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Circadian rhythms and breast cancer: unraveling the biological clock’s role in tumor microenvironment and ageing

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 30, 2024

Breast cancer (BC) is one of the most common and fatal malignancies among women worldwide. Circadian rhythms have emerged in recent studies as being involved pathogenesis breast cancer. In this paper, we reviewed molecular mechanisms by which dysregulation circadian genes impacts development BC, focusing on critical clock genes, brain muscle ARNT-like protein 1 (BMAL1) locomotor output cycles kaput (CLOCK). We discussed how rhythm disruption (CRD) changes tumor microenvironment (TME), immune responses, inflammation, angiogenesis. The CRD compromises surveillance features activities effectors, including CD8+ T cells tumor-associated macrophages, that are important an effective anti-tumor response. Meanwhile, review, discuss bidirectional interactions: age rhythms, aging further increases risk through reduced vasoactive intestinal polypeptide (VIP), affecting suprachiasmatic nucleus (SCN) synchronization, ability to repair damaged DNA, weakened immunity. These complex interplays open new avenues toward targeted therapies combination drugs with chronotherapy potentiate response while reducing progression for better outcomes. This review tries cover broad area emerging knowledge tumor-immune nexus affected

Language: Английский

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Targeting BMAL1 reverses drug resistance of acute myeloid leukemia cells and promotes ferroptosis through HMGB1-GPX4 signaling pathway

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(5)

Published: May 4, 2024

Abstract Purpose Acute myeloid leukemia (AML) is a refractory hematologic malignancy that poses serious threat to human health. Exploring alternative therapeutic strategies capable of inducing modes cell death, such as ferroptosis, holds great promise viable and effective intervention. Methods We analyzed online database data collected clinical samples verify the expression function BMAL1 in AML. conducted experiments on AML proliferation, cycle, chemotherapy resistance by overexpressing/knocking down using assays MDA detection BODIPY 581/591 C11 staining. validated transcriptional regulation HMGB1 through ChIP assay, luciferase RNA level detection, western blotting. Finally, we confirmed results our at animal level. Results up-regulation an observed phenomenon patients. Furthermore, there existed strong correlation between elevated levels inferior prognosis individuals with found knocking inhibited growth blocking cycle. Conversely, overexpressing promoted proliferation. Moreover, research revealed ferroptosis cells BMAL1-HMGB1-GPX4 pathway. can enhance efficacy certain first-line cancer drugs, including venetoclax, dasatinib, sorafenib. Conclusion Our suggest plays crucial regulatory role drug resistance, ferroptosis. could be potential important target for

Language: Английский

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Crosstalk between Circadian Rhythm Dysregulation and Tumorigenesis, Tumor Metabolism and Tumor Immune Response

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Circadian rhythm is a self-regulating 24-hour system that synchronizes with the day and night cycle in organisms. The regulation of this controlled by clock genes, which function to harmoniously express molecular levels facilitate orderly coordination various cellular processes, such as sleep, metabolism, endocrine function, cell proliferation immunity. root cause tumorigenesis body loses its normal growth at genetic level. Long-term disruptions circadian rhythms caused factors shift work, jet lag, unstable sleep patterns can impact health, leading health problems, including cancer. controls most functions related cancer progression, has significant on ability immune cells detect promote their clearance crucial implication for future tumor immunotherapy. This article aims review crosstalk between dysregulation tumorigenesis, response. Additionally, we discuss role disruption therapy, highlighting potential optimize treatment timing improve therapeutic outcomes.

Language: Английский

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Mechanism of action of the Banxia–Xiakucao herb pair in sleep deprivation: New comprehensive evidence from network pharmacology, transcriptomics and molecular biology experiments

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 334, P. 118534 - 118534

Published: Nov. 1, 2024

Language: Английский

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Circadian rhythm disruption and endocrine-related tumors

World Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: 15(7), P. 818 - 834

Published: July 16, 2024

This review delved into the intricate relationship between circadian clocks and physiological processes, emphasizing their critical role in maintaining homeostasis. Orchestrated by interlocked clock genes, timekeeping system regulates fundamental processes like sleep-wake cycle, energy metabolism, immune function, cell proliferation. The central oscillator hypothalamic suprachiasmatic nucleus synchronizes with light-dark cycles, while peripheral tissue are influenced cues such as feeding times. Circadian disruption, linked to modern lifestyle factors night shift work, correlates adverse health outcomes, including metabolic syndrome, cardiovascular diseases, infections, cancer. We explored molecular mechanisms of genes impact on disorders cancer pathogenesis. Specific associations disruption endocrine tumors, spanning breast, ovarian, testicular, prostate, thyroid, pituitary, adrenal gland cancers, highlighted. Shift work is associated increased breast risk,

Language: Английский

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Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: March 11, 2024

Abstract The disruption of circadian rhythms caused by long-term shift work can cause metabolic diseases such as obesity. Early growth response 3 (EGR3) is a member early (EGR) family, which involved in several cellular responses, had been reported rhythm gene suprachiasmatic nucleus. In this research, EGR3 was found to be widely expressed the different tissue human and mice, downregulated adipose obese subjects high-fat diet mice. Moreover, negatively regulated cortisol. addition, key negative modulator hADSCs 3T3-L1 adipogenesis via regulating HDAC6, downstream target regulator lipogenesis. These findings may explain how disorder induced works Our study revealed potential therapeutic alleviate disorders workers provide better health guidance workers.

Language: Английский

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Circadian Rhythms in Anticancer Immunity: Mechanisms and Treatment Opportunities

Annual Review of Immunology, Journal Year: 2024, Volume and Issue: 42(1), P. 83 - 102

Published: June 28, 2024

Circadian rhythms of approximately 24 h have emerged as important modulators the immune system. These oscillations are for mounting short-term, innate responses, but surprisingly also long-term, adaptive responses. Recent data indicate that they play a central role in antitumor immunity, both mice and humans. In this review, we discuss evolving literature on circadian responses underlying mechanisms control them. We further provide an overview treatment regimens-chrono-immunotherapies-that harness time-of-day differences immunity optimal efficacy. Our aim is to researchers clinicians alike, better understanding system how best it chronotherapeutic interventions. This knowledge per se could revolutionize way approach cancer range other diseases, ultimately improving clinical practice.

Language: Английский

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