The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development DOI Creative Commons
Baisuo Zhao, Eugenie Nepovimová, Qinghua Wu

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 16, 2025

The complex interaction between circadian rhythms and physiological functions is essential for maintaining human health. At the heart of this lies PERIOD proteins (PERs), pivotal to clock, influencing timing behavioral processes impacting oxidative stress, immune functionality, tumorigenesis. PER1 orchestrates cooperation enzyme GPX1, modulating mitochondrial dynamics in sync with daily thus regulating mechanisms managing energy substrates. PERs innate cells modulate temporal patterns NF-κB TNF-α activities, as well response LPS-induced toxic shock, initiating inflammatory responses that escalate into chronic conditions. Crucially, cancer cell behaviors including proliferation, apoptosis, migration by levels cycle stimulating expression oncogenes c-Myc MDM2. PER2/3, antagonists stem biology, play important roles differentiating their stemness. Importantly, Pers serve a significant factor early diagnosis prognosis. This review delves link rhythm regulator PERs, disruptions rhythm, oncogenesis. We examine evidence highlights how dysfunctions activities initiate development, aid tumor growth, modify metabolism through pathways involved stress system. Comprehending these connections opens new development rhythm-based therapeutic strategies, aims boosting enhancing treatments.

Language: Английский

Circadian rhythm regulates the function of immune cells and participates in the development of tumors DOI Creative Commons

Yuen Zeng,

Zichan Guo, Mengqi Wu

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: April 27, 2024

Abstract Circadian rhythms are present in almost all cells and play a crucial role regulating various biological processes. Maintaining stable circadian rhythm is essential for overall health. Disruption of this can alter the expression clock genes cancer-related genes, affect many metabolic pathways factors, thereby affecting function immune system contributing to occurrence progression tumors. This paper aims elucidate regulatory effects BMAL1, other on cells, reveal molecular mechanism rhythm’s involvement tumor its microenvironment regulation. A deeper understanding has potential provide new strategies treatment cancer immune-related diseases.

Language: Английский

Citations

35
Basic helix–loop–helix ARNT like 1 regulates the function of immune cells and participates in the development of immune-related diseases DOI Creative Commons
Fanglin Shao, Zhipeng Wang,

Luxia Ye

et al.

Burns & Trauma, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 1, 2025

The circadian clock is an internal timekeeper system that regulates biological processes through a central and peripheral clocks controlling various genes. Basic helix-loop-helix ARNT-like 1 (BMAL1), also known as aryl hydrocarbon receptor nuclear translocator-like protein (ARNTL1), key component of the clock. deletion BMAL1 alone can abolish rhythms human body. plays critical role in immune cell function. Dysregulation linked to immune-related diseases such autoimmune diseases, infectious cancer, vice versa. This review highlights significant governing cells, including their development, differentiation, migration, homing, metabolism, effector functions. study explores how dysregulation have far-reaching implications potentially contribute onset sepsis, trauma. Furthermore, this discusses treatments for target disorders. Understanding impact on function provide insights into pathogenesis help development more effective treatment strategies. Targeting has been demonstrated achieve good efficacy indicating its promising potential targetable therapeutic these diseases.

Language: Английский

Citations

4
Interaction between sleep duration and physical activity on mortality among cancer survivors: findings from National Health and Nutrition Examination Surveys 2007–2018 DOI Creative Commons
Ruyan Chen, Jianglong Han, Si Li

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 17, 2025

Sleep duration and physical activity (PA) are critical factors influencing mortality risk. However, the interaction between sleep PA with risk among cancer survivors has not been well explored. This cross-sectional study utilized data from National Health Nutrition Examination Survey (NHANES) spanning 2007-2018. Multivariable Cox regression analysis restricted cubic splines were employed to evaluate hazard ratios (HRs) 95% confidence intervals (CIs) of association in survivors. Multiplicative additive terms constructed assess effects. The included a total 2,528 adult (aged≥20 years). exhibited U-shaped all-cause cancer-specific mortality, while demonstrating an inverted L-shaped cardiovascular disease (CVD) mortality. Compared physically inactive participants, those adequate had lower risks (HR = 0.542, CI: 0.540-0.543), 0.486, 0.484-0.488), CVD 0.759, 0.755-0.763) A significant was found extreme on (long duration: relative excess due (RERI) 1.514, 1.504-1.525; short RERI 0.725, 0.713-0.737). Extreme lack associated independently jointly. Maintain appropriate doing regular may synergistically improve survival

Language: Английский

Citations

2
The Common Hallmarks of Aging, Circadian Rhythms and Cancer: Implications for Therapeutic Strategies DOI Creative Commons
Jie Wang, Fanglin Shao, Qingxin Yu

et al.

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.

Language: Английский

Citations

2
Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm DOI
Russel J. Reıter, Ramaswamy Sharma, Maira Smaniotto Cucielo

et al.

Cellular and Molecular Life Sciences, Journal Year: 2023, Volume and Issue: 80(4)

Published: March 14, 2023

Language: Английский

Citations

28
Interactions of circadian clock genes with the hallmarks of cancer DOI Creative Commons
Sara M. Ortega-Campos, Eva M. Verdugo‐Sivianes, Ana Amiama-Roig

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(3), P. 188900 - 188900

Published: April 25, 2023

The molecular machinery of the circadian clock regulates expression many genes and processes in organism, allowing adaptation cellular activities to daily light-dark cycles. Disruption rhythm can lead various pathologies, including cancer. Thus, disturbance normal at both genetic environmental levels has been described as an independent risk factor for In addition, researchers have proposed that may a tissue-dependent and/or context-dependent role tumorigenesis function tumor suppressors oncogenes. Finally, core trigger or least be involved different hallmarks Hence, expanding knowledge basis would helpful identify new prognostic markers potential therapeutic targets.

Language: Английский

Citations

25
The Relationship between Circadian Rhythm and Cancer Disease DOI Open Access
Camelia Munteanu,

Sabina Turti,

Larisa Achim

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5846 - 5846

Published: May 28, 2024

The circadian clock regulates biological cycles across species and is crucial for physiological activities biochemical reactions, including cancer onset development. interplay between the rhythm involves regulating cell division, DNA repair, immune function, hormonal balance, potential chronotherapy. This highlights importance of maintaining a healthy prevention treatment. article investigates complex relationship cancer, exploring how disruptions to internal may contribute tumorigenesis influence progression. Numerous databases are utilized conduct searches articles, such as NCBI, MEDLINE, Scopus. keywords used throughout academic archives “circadian rhythm”, ”cancer”, ”circadian clock”. Maintaining cycle prioritizing sleep habits minimizing disruptions, consistent schedules, reduced artificial light exposure, meal timing adjustments. Dysregulation gene can cause tumor growth, leading need regulate better treatment outcomes. components significantly impact cellular responses damage, influencing Understanding rhythm’s role in diseases their therapeutic targets essential treating preventing cancer. Disruptions promote abnormal development metastasis, potentially due system imbalances fluctuations.

Language: Английский

Citations

12
Circadian disruption of feeding-fasting rhythm and its consequences for metabolic, immune, cancer, and cognitive processes DOI Creative Commons
Manuel Tomás Crespo, Laura Lucía Trebucq,

Camila Agustina Senna

et al.

Biomedical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 100827 - 100827

Published: Jan. 1, 2025

The circadian system is composed by a central hypothalamic clock at the suprachiasmatic nuclei (SCN) that communicates with peripheral oscillators for daily coordination of behavior and physiology. SCN entrain to environmental 24-h light-dark (LD) cycle drive rhythms internal synchronizers such as core body temperature, hypothalamic-hypophysary hormones, sympathetic/parasympathetic activity, well behavioral feeding-fasting rhythms, which supply signals setting molecular clocks tissues. Steady phase relationships between keep homeostatic processes microbiota/microbiome composition/activity, metabolic supply/demand, energy balance, immunoinflammatory process, sleep amount quality, psychophysiological stress, etc. Indeed, risk health alterations increase when these are chronically changed prompting disruption (CD), occurring after sudden LD changes (so-called jet-lag), or due activity/feeding-rest/fasting rhythm respect cycles (as humans subjected nightwork, restricting food access rest in mice). Typical pathologies observed animal models CD epidemiological studies include syndrome, type-2 diabetes, obesity, chronic inflammation, cancer, disruption, decrease physical cognitive performance, mood, among others. present review discusses different aspects physiological dysregulations having altered potential translation human health.

Language: Английский

Citations

1
TimeTeller for timing health: The potential of circadian medicine to improve performance, prevent disease and optimize treatment DOI Creative Commons

Benjamin Dose,

Müge Yalçin,

Sebastian P. M. Dries

et al.

Frontiers in Digital Health, Journal Year: 2023, Volume and Issue: 5

Published: April 18, 2023

Circadian medicine, the study of effects time on health and disease has seen an uprising in recent years as a means to enhance performance, optimize treatment timing. Our endogenous generating system -the circadian clock- regulates behavioural, physiological cellular processes. Disruptions clock, via external factors like shift work or jet lag, internal perturbations such genetic alterations, are linked increased risk various diseases obesity, diabetes, cardiovascular cancer. By aligning individual's clock with optimal times for performing daily routines, physical mental also effectiveness certain therapies can be improved. Despite benefits lack non-invasive tools characterizing limits potential field. TimeTeller is molecular/digital tool characterization rhythms prediction including timing, unlock medicine implementing it settings. Given multiple known potentially yet unknown dependent individual rhythms, utility this emerging biomarker best exploited data driven, personalized use cases, using information across lifestyle, care, research

Language: Английский

Citations

21
Light at night and cause-specific mortality risk in Mainland China: a nationwide observational study DOI Creative Commons
Yao Lu, Peng Yin, Jie Wang

et al.

BMC Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: March 16, 2023

Abstract Background While epidemiological studies have found correlations between light at night (LAN) and health effects, none has so far investigated the impacts of LAN on population mortality yet. We aimed to estimate relative risk for from exposure in Mainland China. Methods This time-stratified case-crossover nationwide study used NPP-VIIRS obtain daily data China 2015 2019. The were obtained Disease Surveillance Point System Conditional Poisson regression models applied examine (RR) along each county, then meta-analysis was performed combine county-specific estimates national or regional level. Results A total 579 counties with an average 4.39 (range: 1.02–35.46) included main analysis. overall RRs per 100 nW/cm 2 /sr increases 1.08 (95%CI: 1.05–1.11) all-cause natural-cause mortality. positive association all natural cause-specific observed, which strongest effect observed caused by neuron system disease (RR = 1.32, 95%CI: 1.14–1.52). results robust both younger old, as well males females. more pronounced median LAN-level regions. Combined exposure–response curve, our suggests a non-linear Conclusions Our shows is associated China, particularly disease-related These findings important implications public policy establishment minimize consequences pollution.

Language: Английский

Citations

17