Mitochondria-targeting therapeutic strategies for chronic kidney disease DOI Creative Commons

Annie Sun,

Carol A. Pollock, Chunling Huang

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 116669 - 116669

Published: Nov. 1, 2024

Language: Английский

Preparation of a multiple interacting magnetic fluid for rapid and sensitive simultaneous extraction of β-nicotinamide mononucleotide metabolites in biological samples DOI
Yajie Zhang,

Zhuhui Chen,

Aoli Ye

et al.

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1325, P. 343074 - 343074

Published: Aug. 15, 2024

Language: Английский

Citations

0
Dissection of Targeting Molecular Mechanisms of Celastrol-induced Nephrotoxicity via A Combined Deconvolution Strategy of Chemoproteomics and Metabolomics DOI Creative Commons
Xueying Liu, Qian Zhang, Peili Wang

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(12), P. 4601 - 4617

Published: Jan. 1, 2024

Celastrol (Cel), derived from the traditional herb

Language: Английский

Citations

0
Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications DOI

Mingwei Fan,

Jin-Lan Tian,

Tan Chen

et al.

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 15(10), P. 2041 - 2057

Published: Sept. 26, 2024

Diabetes mellitus (DM) is one of the major causes mortality worldwide, with inflammation being an important factor in its onset and development. This review summarizes specific mechanisms cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator interferon genes (STING) pathway mediating inflammatory responses. Furthermore, it comprehensively presents related research progress subsequent involvement this pathogenesis early-stage DM, diabetic gastroenteropathy, cardiomyopathy, non-alcoholic fatty liver disease, other complications. Additionally, role cGAS-STING autonomic dysfunction intestinal dysregulation, which can lead to digestive complications, has been discussed. Altogether, study provides a comprehensive analysis advances regarding pathway-targeted therapeutic agents prospects for their application precision treatment DM.

Language: Английский

Citations

0
NAD+ enhancers as therapeutic agents in the cardiorenal axis DOI Creative Commons

Mariano Marín-Blázquez,

Jordi Rovira, María José Ramírez-Bajo

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 8, 2024

Cardiorenal diseases represent a complex interplay between heart failure and renal dysfunction, being clinically classified as cardiorenal syndromes (CRS). Recently, the contributions of altered nicotinamide adenine dinucleotide (NAD

Language: Английский

Citations

0
Mitochondria-targeting therapeutic strategies for chronic kidney disease DOI Creative Commons

Annie Sun,

Carol A. Pollock, Chunling Huang

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 116669 - 116669

Published: Nov. 1, 2024

Language: Английский

Citations

0