ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(34), P. 31436 - 31449
Published: Aug. 14, 2023
Liposomes
are
considered
the
best
nanocarrier
for
delivering
cancer
drugs
such
as
chlorin
e6
(Ce6)
and
paclitaxel
(PTX).
However,
poor
stability
non-selectivity
release
of
liposomes
may
severely
limit
their
further
applications.
In
this
study,
based
on
characteristics
lutein
(L)
photo-response
orthoester
(OE)
acid-response,
stable
dual-responsive
(Dr-lips)
have
been
prepared.
The
Dr-lips
exhibited
a
spherical
shape
with
uniform
size
approximately
58.27
nm.
Moreover,
they
displayed
zeta
potential
ranging
from
−45.45
to
−28.25
mV
showed
excellent
storage
stability,
indicating
colloidal
properties.
Additionally,
achieved
high
drug
encapsulation
rates,
92.27%
PTX
90.34%
Ce6,
respectively.
Meanwhile,
under
near-infrared
(NIR)
light
at
660
nm,
Ce6
plays
key
role
in
accelerating
photodegradation
rate
PEG-OE-L
while
also
enhancing
tissue
penetration
ability.
loaded
not
only
pH
photo
dual-responsiveness
targeted
releasing
but
remarkable
reactive
oxygen
species
(ROS)
generation
capacity
impressive
anti-tumor
activity
vitro.
Therefore,
it
provides
novel
strategy
optimizing
delivery
liposome.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(16), P. 3881 - 3907
Published: Jan. 1, 2024
Water
splitting
is
promising,
especially
for
energy
and
environmental
applications;
however,
there
are
limited
studies
on
the
link
between
water
cancer
treatment.
Upconversion
nanoparticles
(UCNPs)
can
be
used
to
convert
near-infrared
(NIR)
light
ultraviolet
(UV)
or
visible
(Vis)
have
great
potential
biomedical
applications
because
of
their
profound
penetration
ability,
theranostic
approaches,
low
self-fluorescence
background,
reduced
damage
biological
tissue,
toxicity.
UCNPs
with
photocatalytic
materials
enhance
activities
that
generate
a
shorter
wavelength
increase
tissue
depth
in
microenvironment
under
NIR
irradiation.
Moreover,
photosensitizer
absorb
it
into
UV/vis
emit
upconverted
photons,
which
excite
photoinitiator
create
H
Biosensors,
Journal Year:
2024,
Volume and Issue:
14(1), P. 40 - 40
Published: Jan. 12, 2024
Due
to
the
limitation
that
natural
peroxidase
enzymes
can
only
function
in
relatively
mild
environments,
nanozymes
have
expanded
application
of
enzymology
biological
field
by
dint
their
ability
maintain
catalytic
oxidative
activity
harsh
environments.
At
same
time,
development
new
and
highly
efficient
composite
has
been
a
challenge
due
limitations
monometallic
particles
applications
inherently
poor
enzyme-mimetic
nanozymes.
The
inherent
enzyme-mimicking
is
Au,
Ag,
Pt,
along
with
other
transition
metals.
Moreover,
nanomaterials
exhibit
excellent
when
composited
materials.
Therefore,
this
paper
focuses
on
simulated
prepared
using
noble
metals
such
as
Pt
metal
nanoparticles
recent
years.
Their
enzymatic
utilized
for
biomedical
glucose
detection,
cancer
cell
detection
tumor
treatment,
antibacterial
applications.
Chemical Engineering Journal,
Journal Year:
2024,
Volume and Issue:
483, P. 149040 - 149040
Published: Jan. 23, 2024
Among
metal-based
nanomaterials,
Copper-based
nanomaterials
(Cu-BNMs)
have
become
a
research
hotspot
in
the
biomedical
field
due
to
their
good
biocompatibility
and
unique
properties.
However,
there
are
fewer
systematic
summaries
of
copper-based
especially
synthesis
Cu-BNMs.
As
for
applications,
Cu-BNMs
been
widely
used
fields
antimicrobial,
imaging,
therapeutics,
showing
excellent
promising
Herein,
this
review
firstly
introduces
classification
various
methods
synthesizing
through
both
top-down
bottom-up
types.
Then,
applications
within
three
tumor
therapy
classified
summarized.
Finally,
challenges
faced
application
future
development
c
discussed
provide
basic
information
illustrations
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Nov. 20, 2024
Cuproptosis
is
an
emerging
mode
of
programmed
cell
death
for
tumor
suppression
but
sometimes
gets
resisted
by
cells
resist
under
specific
mechanisms.
Inhibiting
copper
transporter
ATPase
(ATP7A)
was
found
to
disrupt
ion
homeostasis,
thereby
enhancing
the
effect
cuproptosis
and
eventually
inhibiting
invasion
metastasis.
In
this
study,
we
develop
a
multifunctional
nanoplatfrom
based
on
Cu9S8
(CAPSH),
designed
enhance
in
specifically
targeting
ATP7A
interference,
while
combining
thermodynamic
therapy
with
immune
effects.
The
release
ions
from
CAPSH
homeostasis
interference
siRNA
cooperatively
increases
concentration
cells,
which
induces
effectively
activates
responses
suppressing
development
metastasis
tumor.
This
nanoplatform
simultaneously
regulates
both
principles
onset
development,
facilitating
application
therapy.
limited
regulatory
mechanisms
most
cells.
Here,
group
develops
Cu9S8-based
breast
cancer-targeting
cuproptosis-induction
via
eliciting
cancer
