Molecules,
Journal Year:
2024,
Volume and Issue:
29(16), P. 3854 - 3854
Published: Aug. 14, 2024
This
study
investigates,
in
the
first
part,
synthesis
and
purification
of
a
poorly
crystalline
hydroxyapatite
(HAp)
using
natural
Moroccan
phosphate
(Boucraa
region)
as
raw
material.
Despite
its
successful
preparation,
obtained
HAp
was
contaminated
by
several
metallic
cations
(mostly
Cd,
Pb,
Sn,
Ti,
Mn,
Mg,
Fe,
Al)
migrated
from
rocks
during
digestion
process,
inhibiting
application
sectors.
To
minimize
existence
these
elements,
dissolution-precipitation
technique
(DP)
investigated
non-selective
process.
Following
initial
DP
cycle
conducted
on
precipitated
HAp,
removal
efficiency
approximately
60%
for
Al,
Ti
90%
Cd
Pb.
After
three
consecutive
cycles,
notable
improvement
observed,
reaching
66%
69%
73%
74%
while
were
totally
removed.
In
second
part
this
study,
purified
digested
sulfuric
acid
to
produce
high-quality
phosphoric
(PA)
gypsum
(GP).
The
elemental
analysis
PA
indicates
89%
Fe
over
94%
all
examined
cations.
addition,
generated
GP
dominated
SO
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(34)
Published: June 11, 2024
The
repair
and
functional
reconstruction
of
bone
defects
resulting
from
severe
trauma,
surgical
resection,
degenerative
disease,
congenital
malformation
pose
significant
clinical
challenges.
Bone
tissue
engineering
(BTE)
holds
immense
potential
in
treating
these
defects,
without
incurring
prevalent
complications
associated
with
conventional
autologous
or
allogeneic
grafts.
3D
printing
technology
enables
control
over
architectural
structures
at
multiple
length
scales
has
been
extensively
employed
to
process
biomimetic
scaffolds
for
BTE.
In
contrast
inert
grafts,
next-generation
smart
possess
a
remarkable
ability
mimic
the
dynamic
nature
native
extracellular
matrix
(ECM),
thereby
facilitating
regeneration.
Additionally,
they
can
generate
tailored
controllable
therapeutic
effects,
such
as
antibacterial
antitumor
properties,
response
exogenous
and/or
endogenous
stimuli.
This
review
provides
comprehensive
assessment
progress
3D-printed
BTE
applications.
It
begins
an
introduction
physiology,
followed
by
overview
technologies
utilized
scaffolds.
Notable
advances
various
stimuli-responsive
strategies,
efficacy,
applications
are
discussed.
Finally,
highlights
existing
challenges
development
implementation
scaffolds,
well
emerging
this
field.
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Nov. 1, 2024
Malignant
bone
tumors,
which
are
difficult
to
treat
with
current
clinical
strategies,
originate
from
tissues
and
can
be
classified
into
primary
secondary
types.
Due
the
specificity
of
microenvironment,
results
traditional
means
treating
tumors
often
unsatisfactory,
so
there
is
an
urgent
need
develop
new
treatments
for
malignant
tumors.
Recently,
nanoparticle-based
approaches
have
shown
great
potential
in
diagnosis
treatment.
Nanoparticles
(NPs)
gained
significant
attention
due
their
versatility,
making
them
highly
suitable
applications
tissue
engineering,
advanced
imaging
techniques,
targeted
drug
delivery.
For
diagnosis,
NPs
enhance
contrast
sensitivity
by
integrating
targeting
ligands,
significantly
improve
specific
recognition
localization
tumor
cells
early
detection.
treatment,
enable
delivery,
increasing
accumulation
at
sites
while
reducing
systemic
toxicity.
In
conclusion,
understanding
microenvironment
using
unique
properties
holds
promise
improving
disease
management,
enhancing
treatment
outcomes,
ultimately
quality
life
patients
Further
research
development
will
undoubtedly
contribute
advancement
personalized
medicine
field
oncology.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(8), P. 4139 - 4139
Published: April 9, 2024
Bone
tumors,
particularly
osteosarcoma,
are
prevalent
among
children
and
adolescents.
This
ailment
has
emerged
as
the
second
most
frequent
cause
of
cancer-related
mortality
in
Conventional
treatment
methods
comprise
extensive
surgical
resection,
radiotherapy,
chemotherapy.
Consequently,
management
bone
tumors
regeneration
poses
significant
clinical
challenges.
Photothermal
tumor
therapy
attracted
considerable
attention
owing
to
its
minimal
invasiveness
high
selectivity.
However,
key
challenges
have
limited
widespread
use.
Enhancing
specificity
photosensitizers
through
targeting
or
localized
activation
holds
potential
for
better
outcomes
with
fewer
adverse
effects.
Combinations
chemotherapies
immunotherapies
also
present
avenues
improvement.
In
this
review,
we
provide
an
overview
recent
strategies
aimed
at
overcoming
limitations
photothermal
(PTT),
along
current
research
directions
context
including
(1)
target
strategies,
(2)
combined
multiple
therapies
(immunotherapies,
chemotherapies,
chemodynamic
therapies,
magnetic,
photodynamic
therapies),
(3)
bifunctional
scaffolds
regeneration.
We
delve
into
pros
cons
these
combination
explore
focal
points.
Lastly,
address
prospects
therapy.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
resection
of
bone
tumors
results
in
large
defects
with
some
residual
tumor
cells,
and
the
treatment
this
type
defect
area
often
faces
a
dilemma,
namely,
trade-off
between
repair
antitumor
after
tumors.
In
order
to
promote
local
repair,
at
same
time
inhibit
recurrence
by
continuous
controlled
drug
administration,
we
developed
multifunctional
NIR-responsive
scaffold,
whose
main
components
are
polylactic
acid
MXene,
loaded
PLGA/DOX
microspheres,
hope
that
scaffold
can
take
into
account
both
bidirectional
modulation
effect
NIR.
showed
1%
MXene
content
had
relatively
good
performance
photothermal
therapy
(PT)
other
aspects,
it
could
be
smoothly
increased
50
°C
within
2
min
under
NIR
illumination,
release
microspheres
was
10%
illumination
compared
body
temperature.
vivo
experiments
animals
effectively
limited
situ
cells
lung
metastasis
able
osteogenic
differentiation
irradiation.
Therefore,
not
only
control
drugs
but
also
enhance
through
PT
formation,
which
provides
application
solution
for
integrated
surgery.
