GSH-Responsive Liposomes with Heat Shock Protein Regulatory Ability for Efficient Photodynamic/Photothermal Combined Therapy of Tumors
Hairui Deng,
No information about this author
Xianan Li,
No information about this author
Lingfeng Pan
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et al.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(20), P. 25788 - 25798
Published: May 8, 2024
Phototherapy,
represented
by
photodynamic
therapy
(PDT)
and
photothermal
(PTT),
has
great
potential
in
tumor
treatment.
However,
the
presence
of
antioxidant
glutathione
(GSH)
heat
shock
proteins
(HSPs)
expression
caused
high
temperature
can
weaken
effects
PDT
PTT.
Here,
a
multifunctional
nanocomplex
BT&GA@CL
is
constructed
to
realize
enhanced
synergistic
PDT/PTT.
Cinnamaldehyde
liposomes
(CLs)
formed
cinnamaldehyde
dimer
self-assembly
were
loaded
with
gambogic
acid
(GA)
an
aggregation-induced
emission
molecule
BT
obtain
BT&GA@CL.
As
drug
carrier,
CL
consume
release
drugs
responsively.
The
released
aggregates
simultaneously
act
as
both
agent
photosensitizer
achieve
PTT
under
660
nm
laser
irradiation.
Specifically,
GA
HSP90
inhibitor
attenuate
PTT-induced
protein
expression,
thereby
weakening
tolerance
cells
temperatures
enhancing
Such
modulates
content
GSH
cells,
thus
PTT,
ultimately
achieving
goal
efficient
combined
suppression.
Language: Английский
Current advances in nanozyme-based nanodynamic therapies for cancer
Xiangyang Zhou,
No information about this author
Shuaipeng Feng,
No information about this author
Qingqing Xu
No information about this author
et al.
Acta Biomaterialia,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
Language: Английский
Efficient bimetallic nanozyme precisely tuned by DNA for high-throughput foldable paper biosensing
Hongyan Zhang,
No information about this author
Zhihan Wu,
No information about this author
Haijun Lu
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et al.
Chemical Engineering Journal,
Journal Year:
2024,
Volume and Issue:
unknown, P. 158504 - 158504
Published: Dec. 1, 2024
Language: Английский
Recent advances in polydopamine-coated metal–organic frameworks for cancer therapy
Jingchao He,
No information about this author
Guangtian Wang,
No information about this author
Yongfang Zhou
No information about this author
et al.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: April 1, 2025
The
creation
and
development
of
classical
multifunctional
nanomaterials
are
crucial
for
the
advancement
nanotherapeutic
treatments
tumors.
Currently,
metal–organic
frameworks
(MOFs)
modified
with
polydopamine
(PDA)
at
forefront
nanomedicine
research,
particularly
in
tumor
diagnostics
therapy,
owing
to
their
exceptional
biocompatibility,
expansive
specific
surface
area,
multifaceted
functionalities,
superior
photothermal
properties,
which
led
significant
advancements
anti-tumor
research.
Consequently,
a
range
anti-cancer
strategies
has
been
devised
by
leveraging
capabilities
MOFs,
including
intelligent
drug
delivery
systems,
photodynamic
tailored
microenvironment.
In
order
gain
deeper
insight
into
role
MOFs@PDA
cancer
diagnosis
treatment,
it
is
essential
conduct
comprehensive
review
existing
research
outcomes
promptly
analyze
challenges
associated
biological
applications.
This
will
provide
valuable
perspectives
on
potential
clinical
settings.
Language: Английский
Hyaluronic acid-coated porphyrin nanoplatform with oxygen sustained supplying and glutathione depletion for enhancing photodynamic/ion/chemo synergistic cancer treatment
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
278, P. 134661 - 134661
Published: Aug. 12, 2024
Language: Английский