Determination of Perfluorinated Substances (Pfas) in Certain Foodstuffs According to Newly Established Eu Legislation DOI Creative Commons
Elina Pasecnaja, Dzintars Začs

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 12, 2024

Abstract Per- and polyfluorinated alkyl substances (PFAS) are compounds which exhibit unique chemical physical properties resulting in bioaccumulation aquatic terrestrial food chains. Due to a global concern on the adverse health effects, European Food Safety Authority (EFSA) set tolerable weekly intake thereafter, ensure an efficient protection of public health, Commission maximum levels for four priority components, namely perfluorooctanoic acid (PFOA), perfluorononanoic (PFNA), perfluorohexanesulfonic (PFHxS), perfluorooctanesulfonic (PFOS), certain foodstuffs. This study demonstrates analytical method based high performance liquid chromatography (HPLC) coupled Orbitrap mass spectrometry (Orbitrap-MS) quantitative determination PFAS. The optimized validated LC-Orbitrap-MS fulfils requirements specified “Guidance Document Analytical Parameters Determination Polyfluoroalkyl Substances Feed” allows reliable analysis PFAS selected products, fulfilling Regulation 915/2023, (EU) 2022/1428, Recommendation 2022/1431. was successfully used compliance testing according newly established legislation samples (n=58) collected Latvia, providing occurrence data from Baltic states.

Language: Английский

A systematic review for non-targeted analysis of per- and polyfluoroalkyl substances (PFAS) DOI Creative Commons
David Megson, Pennante Bruce-Vanderpuije, Ifeoluwa Idowu

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 960, P. 178240 - 178240

Published: Jan. 1, 2025

This review follows the PRISMA guidelines to provide a systematic of 115 peer reviewed articles that used non-targeted analysis (NTA) methods detect per- and polyfluoroalkylated substances (PFAS). literature highlights significant positive impact NTA in understanding PFAS environment. Within geographical bias exists, with most studies (∼60 %) conducted United States China. Future other regions (such as South America Africa) are needed gain more global understanding. More research is required marine environments atmosphere, current focus mainly on freshwater, groundwater, soil, sediments. The majority measuring environment, rather than commercial products (with exception AFFF). Non-lethal blood sampling has been successful for humans wildlife, but additional biomonitoring exposed cohorts understand health risks biotransformation pathways. mostly use liquid chromatography negative ionisation, which biases towards detection specific PFAS. Despite improvements data reporting quality assurance control (QA/QC) procedures, factors such false rates often overlooked, many workflows remain highly subjective. Perfluoroalkyl carboxylic acids (PFCAs) perfluoroalkyl sulfonic (PFSAs) detected classes, identified over 80 % studies, common routine monitoring. However, our >1000 from total 382 different 300 classes found fewer 5 studies. variety present limitations relying solely targeted methods. monitoring programs regulations would benefit considering comprehensive information

Language: Английский

Citations

4
Advancements in detection techniques for per- and polyfluoroalkyl substances: A comprehensive review DOI

Yahan Cui,

Shenghui Wang, Dandan Han

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 176, P. 117754 - 117754

Published: May 8, 2024

Language: Английский

Citations

11
Effective pre-concentration of volatile per- and polyfluoroalkyl substances from gas and aqueous phase via solid-phase microextraction DOI
Héctor Martínez-Pérez-Cejuela,

M. Williams,

C. P. McLeod

et al.

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1345, P. 343746 - 343746

Published: Jan. 31, 2025

Language: Английский

Citations

1
Progress and Challenge of Sensors for Dairy Food Safety Monitoring DOI Creative Commons
Alfonso Fernández‐González, Rosana Badía‐Laíño, José M. Costa‐Fernández

et al.

Sensors, Journal Year: 2024, Volume and Issue: 24(5), P. 1383 - 1383

Published: Feb. 21, 2024

One of the most consumed foods is milk and products, guaranteeing suitability these products one major concerns in our society. This has led to development numerous sensors enhance quality controls food chain. However, this not a simple task, because it necessary establish parameters be analyzed often, only compound responsible for contamination or degradation. To attempt address problem, multiplex analysis together with non-directed (e.g., general such as pH) are relevant alternatives identifying safety dairy food. In recent years, use new technologies devices/platforms optical electrochemical signals accelerated intensified pursuit systems that provide simple, rapid, cost-effective, and/or multiparametric response presence contaminants, markers various diseases, indicators levels. achieving simultaneous determination two more analytes situ, single measurement, real time, using working ‘real sensor’, remains daunting challenges, primarily due complexity sample matrix. requirements, different approaches have been explored. The state art on will summarized review including optical, electrochemical, other sensor-based detection methods magnetoelastic mass-based sensors.

Language: Английский

Citations

6
Determination of Perfluorinated Substances (PFAS) Using LC-ORBITRAP-MS in Certain foodstuffs of Animal Origin According to newly established EU legislation DOI
Elina Pasecnaja, Dzintars Začs

Food Analytical Methods, Journal Year: 2024, Volume and Issue: 17(4), P. 640 - 649

Published: Feb. 28, 2024

Language: Английский

Citations

4
Transforming PFAS management: A critical review of machine learning applications for enhanced monitoring and treatment DOI
Md Hasan-Ur Rahman,

Rabbi Sikder,

Tanvir Ahamed Tonmoy

et al.

Journal of Water Process Engineering, Journal Year: 2025, Volume and Issue: 70, P. 106941 - 106941

Published: Jan. 15, 2025

Language: Английский

Citations

0
Practicality evaluation of novel microextraction techniques for the determination of PFAS in food and water samples using the Blue Applicability Grade Index DOI
Natalia Manousi, Aristidis N. Anthemidis, Erwin Rosenberg

et al.

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 343864 - 343864

Published: Feb. 1, 2025

Language: Английский

Citations

0
Sensitive and Accurate Determination of 32 PFAS in Human Serum Using Online SPE-UHPLC-HRMS DOI Creative Commons
Masho Hilawie Belay, Elisa Robotti,

Arianna Ghignone

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 485, P. 136780 - 136780

Published: Dec. 5, 2024

Per- and polyfluoroalkyl substances' (PFAS) extreme persistence has been linked to many adverse effects on human health including increased risk of certain cancers. This study presents the development validation a new, highly sensitive method for quantification 32 PFAS in serum using online solid-phase extraction (SPE) coupled with ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS). Legacy emerging were targeted. Main steps sample pretreatment include protein precipitation (PP), pellet rinsing, centrifugation, preconcentration through solvent evaporation, SPE weak anion-exchange polymeric sorbent. The PP pellet-rinsing procedures optimized comprehensive exploration combinations. Following this, that offers best compromise targeted was identified principal component analysis. demonstrated excellent linearity (R² = 0.977-0.997) limits ranging from 8.9 27 ng/L, 5 15 times lower than previous methods. Precision (intraday 2.6-14.0 % interday 1.3-11.0 relative standard deviation) accuracy (recoveries 72.7-106 %) robust. validated accordance ISO/IEC 17025 successfully applied five samples, confirming its suitability high-throughput profiling biomonitoring studies. is first use simultaneous determination broad range PFAS, ether congeners such as perfluoro(2-ethoxyethane) sulfonic acid Nafion byproduct 2. Furthermore, control charts employed assess instrument during routine analysis implement necessary actions.

Language: Английский

Citations

3
Integration of ultrashort-chain compounds into the biomonitoring of per- and polyfluorinated substances in human plasma and serum DOI Creative Commons
Shun‐Hsin Liang, Justin A. Steimling

Journal of Chromatography Open, Journal Year: 2024, Volume and Issue: 5, P. 100132 - 100132

Published: April 19, 2024

Ultrashort-chain (USC) per- and polyfluoroalkyl substances (PFAS) are small very polar compounds with carbon chain lengths of shorter than C4. Their ubiquitous high levels occurrence in environmental aquatic systems have raised significant concern conjunction long-chain PFAS contamination. Measuring USC blood can not only monitor human exposure but also serves as a valuable tool for studying the potential risks associated exposure. The polarity poses challenge to current analytical practices based on reversed-phase liquid chromatography, primarily due insufficient chromatographic retention. In this study, simple reliable workflow was developed simultaneous analysis C1 C10 perfluoroalkyl carboxylic sulfonic acids, along four alternative PFAS, plasma serum. conducted using polar-embedded LC column. Fetal bovine serum (FBS) chosen method validation its absence all analytes, except trifluoroacetic acid (TFA). Subsequently, TFA isotope, 13C-TFA, employed surrogate assess accuracy FBS. A single-step sample preparation procedure, by mixing 100 µL FBS 200 methanol, demonstrated be effective accurate precise fortified samples. Ten isotopes C3 serving extracted internal standards, were added samples at 1 ppb validate entire workflow. Calibration standards prepared reverse osmosis water cleanliness analytes. Phosphate-buffered saline incorporated into calibration standard solution achieve similar performance between solutions. ranges varied among different spanning from 0.05 – 40 ppb, 0.1 0.25 0.5 ppb. Method precision evaluated three fortification levels, ranging 0.4 30 All analytes exhibited recovery values within 20% nominal concentration across levels. Satisfactory %RSD <12%. validated applied measure NIST 1950 1957 reference serum, affirming established is suitable quantification matrices.

Language: Английский

Citations

2
Development and Application of a Liquid Chromatography–Tandem Mass Spectrometry Method for the Analysis of 20 Perfluoroalkyl Substances in Fruit and Vegetables at Sub-Parts-per-Trillion Levels DOI Creative Commons
Ruben Kause, S.P.J. van Leeuwen, Kerstin Krätschmer

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(33), P. 18731 - 18741

Published: Aug. 7, 2024

In response to the European Food Safety Authority's establishment of a tolerable weekly intake (TWI) for sum PFOA, PFNA, PFHxS, and PFOS, method was developed quantify confirm 20 PFASs at sub-parts-per-trillion level in fruit vegetables. Improved sensitivity achieved by (i) increasing sample intake, (ii) decreasing solvent volume final extract, (iii) using highly sensitive mass spectrometer. Except PFTrDA, target could be quantitatively determined with an apparent recovery 90–119%, limits quantitation down 0.5 ng/kg, relative standard deviation under within-laboratory reproducibility conditions <28%. The successfully applied 215 vegetable samples obtained from local grocery stores markets. Leafy vegetables prove main category responsible PFAS exposure, mainly followed PFHpA PFHxA.

Language: Английский

Citations

2