Nanomaterials-based photothermal therapy and its potentials in antibacterial treatment

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 328, P. 251 - 262

Published: Sept. 1, 2020

Language: Английский

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CRISPR/Cas9 therapeutics: progress and prospects

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Jan. 16, 2023

Abstract Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing technology is the ideal tool of future for treating diseases by permanently correcting deleterious base mutations or disrupting disease-causing genes with great precision and efficiency. A variety efficient Cas9 variants derivatives have been developed to cope complex genomic changes that occur during diseases. However, strategies effectively deliver CRISPR system diseased cells in vivo are currently lacking, nonviral vectors target recognition functions may be focus research. Pathological physiological resulting from disease onset expected serve as identifying factors targeted delivery targets gene editing. Diseases both varied complex, choice appropriate methods different important. Meanwhile, there still many potential challenges identified when targeting CRISPR/Cas9 treatment. This paper reviews current developments three aspects, namely, type, vector, characteristics. Additionally, this summarizes successful examples clinical trials finally describes possible problems associated applications.

Language: Английский

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Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy

Nano Today, Journal Year: 2021, Volume and Issue: 37, P. 101073 - 101073

Published: Jan. 10, 2021

Language: Английский

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Advances in nanomaterial-based targeted drug delivery systems

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: April 13, 2023

Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety and therapeutic efficacy of encapsulated drugs due their unique physicochemical biological properties. By combining with nanoparticles using rational targeting pathways, nano-targeted were created overcome main drawbacks conventional treatment, including insufficient stability solubility, lack transmembrane transport, short circulation time, undesirable toxic effects. Herein, we reviewed recent developments in different design strategies approaches employing various nanomaterial-based systems. We also discussed challenges perspectives smart precisely intravascular extravascular diseases.

Language: Английский

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Green Carbon Dots: Synthesis, Characterization, Properties and Biomedical Applications

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(1), P. 27 - 27

Published: Jan. 2, 2023

Carbon dots (CDs) are a new category of crystalline, quasi-spherical fluorescence, "zero-dimensional" carbon nanomaterials with spatial size between 1 nm to 10 and have gained widespread attention in recent years. Green CDs synthesised from renewable biomass such as agro-waste, plants or medicinal other organic biomaterials. Plant-mediated synthesis is green chemistry approach that connects nanotechnology the CDs. Notably, made technology economical far superior those manufactured physicochemical methods due their exclusive benefits, being affordable, having high stability, simple protocol, safer eco-benign. can be synthesized by using ultrasonic strategy, chemical oxidation, carbonization, solvothermal hydrothermal processes, microwave irradiation various plant-based resources. diverse applications biomedical fields bioimaging, biosensing nanomedicine, which ascribed unique properties, including excellent luminescence effect, strong stability good biocompatibility. This review mainly focuses on synthesis, characterization techniques, beneficial properties plant resource-based applications. article also looks at research gaps future directions for continuous deepening exploration

Language: Английский

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Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 170, P. 142 - 199

Published: Jan. 11, 2021

Language: Английский

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Antigen Capture and Immune Modulation by Bacterial Outer Membrane Vesicles as In Situ Vaccine for Cancer Immunotherapy Post‐Photothermal Therapy

Small, Journal Year: 2022, Volume and Issue: 18(14)

Published: Feb. 12, 2022

Abstract Tumor antigens released from tumor cells after local photothermal therapy (PTT) can activate the tumor‐specific immune responses, which are critical for eliminating residual lesions and distant metastases. However, limited recognition efficiency of by system immunosuppressive microenvironment lead to ineffective antitumor immunity. Here, an in situ multifunctional vaccine based on bacterial outer membrane vesicles (OMVs, 1‐MT@OMV‐Mal) is developed surface conjunction maleimide groups (Mal) interior loading with inhibitor indoleamine 2, 3‐dioxygenase (IDO), 1‐methyl‐tryptophan (1‐MT). 1‐MT@OMV‐Mal bind PTT, be efficiently recognized taken up dendritic cells. Furthermore, injection simultaneously overcomes inhibition IDO tumor‐infiltrating effector T cells, leading remarkable both primary tumors. Together, a promising OMVs facilitate immune‐mediated clearance PTT through orchestrating antigen capture modulation presented.

Language: Английский

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Recent advances in long-acting drug delivery systems for anticancer drug

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 194, P. 114724 - 114724

Published: Feb. 4, 2023

The use of systemic anticancer chemotherapy is intrinsically limited by its toxicity. Whether dealing with small molecules or biopharmaceuticals, after administration, doses fail to reach effective intratumoral concentrations, while high significant tumor inhibition effects may also drive the death healthy cells, endangering patients. Therefore, strategies based on drug delivery systems (DDSs) for avoiding toxicity have been designed. Due their ability protect drugs from early elimination and control release, DDSs can foster exposure therapeutics extending circulation time steadily releasing into sites. However, approval tailored clinical minimal as safety in vivo activity still need be ameliorated manipulating physicochemical characteristics. During last few years, several described improve safety, stability, fine-tune pharmaceuticals release kinetics. Herein, we reviewed main DDSs, namely polymeric conjugates, nano microparticles, hydrogels, microneedles, explored long-acting treatments, highlighting recently proposed modifications potential advantages different therapies. Additionally, important limitations therapies future technology directions were covered.

Language: Английский

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Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 1, 2023

The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers the antitumor immune response. Here, we report a denaturation-and-penetration strategy use tin monosulfide nanoparticles (SnSNPs) as nano-sonosensitizers that can overcome stromal barrier for management triple-negative breast cancer (TNBC). SnSNPs possess narrow bandgap (1.18 eV), allowing efficient electron (e-)-hole (h+) pair separation to generate reactive oxygen species under US activation. More importantly, display mild photothermal properties in situ denature collagen facilitate deep into mass upon near-infrared irradiation. This approach significantly enhances sonodynamic therapy (SDT) by boosts immunity. In mouse models malignant TNBC hepatocellular carcinoma (HCC), combination robust SDT enhanced cytotoxic T lymphocyte infiltration achieves remarkable anti-tumor efficacy. study presents an innovative enhance immunity using strategy, offering potential combined sono-immunotherapy nanomedicine field.

Language: Английский

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Dynamic Adjust of Non‐Radiative and Radiative Attenuation of AIE Molecules Reinforces NIR‐II Imaging Mediated Photothermal Therapy and Immunotherapy

Advanced Science, Journal Year: 2022, Volume and Issue: 9(8)

Published: Jan. 22, 2022

Due to the aggregation-caused quenching effect and near-infrared I poor penetration capabilities of common fluorescent molecules, their applications in visualized imaging photoactivated treatment are limited. Therefore, new II (NIR-II) molecule (named TST), which had abilities aggregation-induced emission (AIE) photothermal therapy synthesized. Moreover, order further improve its yield therapeutic effect, camptothecin prodrug (CPT-S-PEG) novel immune checkpoint inhibitor AZD4635 used co-assemble with TST into nanoparticles for drug delivery. On account strong interaction TST, intramolecular rotation is limited, thereby inhibiting non-radiation attenuation promoting fluorescence generation when intact. As uptake by cancer cells, redox sensitive CPT-S-PEG degraded disintegrate. The released enhances non-radiative expedites conversion because removal constraint camptothecin. Furthermore, induces immunogenic cell death cells releases abundant ATP tumor microenvironment recruit cells. However, superfluous converted immunosuppressive adenosine through CD39-CD73-A2AR pathway. disintegration just blocks this pathway timely, achieving favorable synergistic therapy, chemotherapy, immunotherapy.

Language: Английский

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