Pharmaceutics,
Journal Year:
2021,
Volume and Issue:
13(2), P. 155 - 155
Published: Jan. 25, 2021
Nanotechnology
platforms,
such
as
nanoparticles,
liposomes,
dendrimers,
and
micelles
have
been
studied
extensively
for
various
drug
deliveries,
to
treat
or
prevent
diseases
by
modulating
physiological
pathological
processes.
The
delivery
molecules
range
from
traditional
small
recently
developed
biologics,
proteins,
peptides,
nucleic
acids.
Among
them,
proteins
shown
a
series
of
advantages
potential
in
therapeutic
applications,
introducing
due
genetic
defects,
used
nanocarriers
anticancer
agents
decelerate
tumor
growth
control
metastasis.
This
review
discusses
the
existing
nanoparticle
systems,
design
strategies,
using
each
system,
possible
limitations.
Moreover,
we
will
examine
intracellular
different
protein
therapeutics,
antibodies,
antigens,
gene
editing
into
host
cells
achieve
effects
cancer
vaccines.
Finally,
explore
current
applications
treatments.
Nano Letters,
Journal Year:
2022,
Volume and Issue:
22(15), P. 6418 - 6427
Published: July 20, 2022
Aberrant
energy
metabolism
not
only
endows
tumor
cells
with
unlimited
proliferative
capacity
but
also
contributes
to
the
establishment
of
glucose-deficient/lactate-rich
immunosuppressive
microenvironment
(ITM)
impairing
antitumor
immunity.
Herein,
a
novel
metabolic
nanoregulator
(D/B/CQ@ZIF-8@CS)
was
developed
by
enveloping
2-deoxy-d-glucose
(2-DG),
BAY-876,
and
chloroquine
(CQ)
into
zeolitic
imidazolate
framework-8
(ZIF-8)
simultaneously
deprive
energy/nutrition
supply
relieve
ITM
for
synergetic
starvation-immunotherapy.
Aerobic
glycolysis,
glucose
uptake,
autophagy
flux
could
be
concurrently
blocked
D/B/CQ@ZIF-8@CS,
cutting
off
nutrition/energy
source
lactate.
Furthermore,
inhibition
uptake
aerobic
glycolysis
effectively
reverse
ITM,
thus
functionally
inactivating
regulatory
T
augmenting
anti-CTLA-4
immunotherapy.
Such
two-pronged
strategy
would
provide
new
insights
design
intervention-based
synergistic
cancer
therapy.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: April 29, 2023
Abstract
The
survival
of
malignant
tumors
is
highly
dependent
on
their
intrinsic
self-defense
pathways
such
as
heat
shock
protein
(HSP)
during
cancer
therapy.
However,
precisely
dismantling
self-defenses
to
amplify
antitumor
potency
remains
unexplored.
Herein,
we
demonstrate
that
nanoparticle-mediated
transient
receptor
potential
vanilloid
member
1
(TRPV1)
channel
blockade
potentiates
thermo-immunotherapy
via
suppressing
factor
(HSF1)-mediated
dual
pathways.
TRPV1
inhibits
hyperthermia-induced
calcium
influx
and
subsequent
nuclear
translocation
HSF1,
which
selectively
suppresses
stressfully
overexpressed
HSP70
for
enhancing
thermotherapeutic
efficacy
against
a
variety
primary,
metastatic
recurrent
tumor
models.
Particularly,
the
suppression
HSF1
further
restrains
transforming
growth
β
(TGFβ)
pathway
degrade
stroma,
improves
infiltration
therapeutics
(e.g.
anti-PD-L1
antibody)
immune
cells
into
fibrotic
immunosuppressive
pancreatic
cancers.
As
result,
retrieves
with
tumor-eradicable
memory
effects.
represents
an
effective
approach
dismantle
potent
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(3), P. 3026 - 3042
Published: Jan. 11, 2023
This
work
describes
the
syntheses,
structural
characterization,
and
biological
profile
of
Mn(II)-
Zn(II)-based
complexes
1
2
derived
from
aroyl-hydrazone
Schiff
base
ligand
(L1).
The
synthesized
compounds
were
thoroughly
characterized
by
elemental
analysis,
Fourier
transform
infrared
spectroscopy
(FTIR),
UV-vis,
electron
paramagnetic
resonance
(EPR),
nuclear
magnetic
(NMR),
single-crystal
X-ray
diffraction
(s-XRD).
Density
functional
theory
(DFT)
studies
performed
to
ascertain
electronic
properties.
Hirshfeld
surface
analysis
was
used
investigate
different
intermolecular
interactions
that
define
stability
crystal
lattice
structures.
To
therapeutic
potential
2,
in
vitro
interaction
carried
out
with
ct-DNA
bovine
serum
albumin
(BSA)
using
analytical
multispectroscopic
techniques,
results
showed
more
avid
binding
complex
than
L1.
antioxidant
examined
against
2,2-diphenyl
picrylhydrazyl
(DPPH)
free
radical,
which
revealed
better
ability
Mn(II)
complex.
Moreover,
antibacterial
activity
tested
Gram-positive
Gram-negative
bacteria
demonstrated
effective
bactericidal
L1
toward
bacteria.
Furthermore,
cytotoxicity
assessment
MDA-MB-231
(triple
negative
breast
cancer)
A549
(lung)
cancer
cell
lines.
cytotoxic
polymeric
Zn(II)
exhibited
selective
line
as
evidenced
its
low
IC50
value.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(22)
Published: April 11, 2023
Owing
to
their
long
absorption
wavelengths,
high
molar
absorptivity,
and
tunable
photosensitivity,
phthalocyanines
have
been
widely
used
in
photodynamic
therapy
(PDT).
However,
still
face
the
drawbacks
of
poor
targeting,
"always-on"
photosensitizing
properties,
unsatisfactory
therapeutic
efficiency,
which
limit
wide
applications
biomedical
fields.
Thus,
new
design
strategies
such
as
modification
targeting
molecules,
formation
nanoparticles,
activating
photosensitizers
are
developed
improve
above
defects.
Notably,
recent
studies
shown
that
novel
not
only
fluorescence
imaging
PDT,
but
also
photoacoustic
imaging,
photothermal
sonodynamic
therapy,
therapy.
This
review
focuses
on
strategies,
biomedicine,
clinical
development
phthalocyanines,
providing
ideas
references
for
application
phthalocyanine,
so
promote
future
transformation
into
applications.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(17), P. 16743 - 16756
Published: Aug. 24, 2023
Chemodynamic
therapy
(CDT)
is
a
highly
tumor-specific
treatment,
while
its
efficacy
compromised
by
the
intratumoral
Fenton
reaction
efficiency,
which
determined
following
factors,
including
availability
of
ions
(e.g.,
Fe2+),
amount
H2O2,
and
degree
acidity.
Synchronous
optimization
these
factors
big
challenge
for
efficient
CDT.
Herein,
strategy
comprehensively
optimizing
was
developed
traceable
multistage
augmented
CDT
charge-reversal
theranostics.
The
customized
pH-responsive
poly(ethylene)glycol-poly(β-amino
esters)
(PEG-PAE)
micelle
(PM)
prepared
as
carrier.
Glucose
oxidase
(GOx),
Fe2+,
second
near-infrared
(NIR-II)
LET-1052
probe
were
coloaded
PM
to
obtain
final
activity
metastable
Fe2+
remained
unsaturated
coordination
with
PEG-PAE.
Then
tumor
accumulation
exposure
achieved
cationization
PEG-PAE,
further
enhanced
GOx
catalysis-triggered
pH
decrease.
Together
abundant
H2O2
generation
decrease
through
catalysis,
limiting
optimized,
achieving
both
in
vitro
vivo.
These
findings
provide
overcome
intrinsic
drawbacks
current
Polymers,
Journal Year:
2023,
Volume and Issue:
15(16), P. 3354 - 3354
Published: Aug. 10, 2023
With
the
success
of
several
clinical
trials
products
based
on
human
serum
albumin
(HSA)
and
rapid
development
nanotechnology,
HSA-based
nanodrug
delivery
systems
(HBNDSs)
have
received
extensive
attention
in
field
nanomedicine.
However,
there
is
still
a
lack
comprehensive
reviews
exploring
broader
scope
HBNDSs
biomedical
applications
beyond
cancer
therapy.
To
address
this
gap,
review
takes
systematic
approach.
Firstly,
it
focuses
crystal
structure
potential
binding
sites
HSA.
Additionally,
provides
summary
recent
progresses
for
various
over
past
five
years,
categorized
according
to
type
therapeutic
drugs
loaded
onto
These
categories
include
small-molecule
drugs,
inorganic
materials
bioactive
ingredients.
Finally,
summarizes
characteristics
current
application
status
drug
delivery,
also
discusses
challenges
that
need
be
addressed
transformation
HSA
formulations
offers
future
perspectives
field.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(10)
Published: Jan. 31, 2023
Breast-conserving
surgery
(BCS)
is
the
predominant
treatment
approach
for
initial
breast
cancer.
However,
due
to
a
lack
of
effective
methods
evaluating
BCS
margins,
local
recurrence
caused
by
positive
margins
remains
an
issue.
Accordingly,
radiation
therapy
(RT)
common
modality
in
patients
with
advanced
while
RT
also
protects
normal
tissue
and
enhances
tumor
bed
doses
improve
therapeutic
effects,
current
radiosensitizers
cannot
meet
these
urgent
clinical
needs.
To
address
this,
novel
self-assembled
multifunctional
nanoprobe
(NP)
gadolinium
(Gd)-diethylenetriaminepentaacetic
acid-human
serum
albumin
(HSA)@indocyanine
green-Bevacizumab
(NPs-Bev)
synthesized
efficacy
fluorescence-image-guided
RT.
Fluorescence
image
guidance
second
near
infrared
NP
improves
complete
resection
tumor-bearing
mice
accurately
discriminates
between
benign
malignant
mammary
transgenic
mice.
Moreover,
targeting
tumors
NPs
induces
more
reactive
oxygen
species
under
X-ray
therapy,
which
not
only
increases
sensitivity,
but
reduces
progression
Interestingly,
NPs-Bev
using
HSA,
magnetic
resonance
contrast
agent
Bevacizumab-targeting
vascular
growth
factor
A,
are
clinically
safe
reagents,
vitro
vivo.
Therefore,
provide
solid
precision
platform
treat
