Insights into Tumor Microenvironment (TME) and the Nano Approaches to Suppress Tumor Growth DOI Creative Commons
Perpetua Takunda Kutoka, Theodora Amanda Seidu, Vongai Baye

et al.

OpenNano, Journal Year: 2022, Volume and Issue: 7, P. 100041 - 100041

Published: April 6, 2022

Cancer, the second major cause of death after cardiovascular disease has been reported to have resulted in over 10 million deaths worldwide per year, on average. Resistance therapeutic interventions is a definitive characteristic cancer, where acquired resistance become challenge that significantly reduced anti-tumor efficiency cancer therapy. The tumor microenvironment (TME) heavily responsible for these cell-targeted drug delivery system challenges due its abundant physiological and pathological barriers impair tumoral penetration distribution nanotherapeutics. However, unique TME characteristics also make an attractive target focus intense research development antitumor nanomedicine strategies can directly or modulate it. In this review, we summarize developed overcome obstacles against nano-drug consequently improve efficiency.

Language: Английский

Current advance of nanotechnology in diagnosis and treatment for malignant tumors DOI Creative Commons

Bilan Wang,

Shiqi Hu, Yan Teng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

Citations

87
Dissolvable Self‐Locking Microneedle Patches Integrated with Immunomodulators for Cancer Immunotherapy DOI Creative Commons

Seung‐Hwan Joo,

Jaehyun Kim, Juhyeong Hong

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(10)

Published: Dec. 18, 2022

Abstract Advancements in micro‐resolution 3D printers have significantly facilitated the development of highly complex mass‐producible drug delivery platforms. Conventionally, due to limitations micro‐milling machineries, dissolvable microneedles (MNs) are mainly fabricated cone‐shaped geometry with limited accuracy. Herein, overcome conventional MNs, a novel projection micro‐stereolithography printer‐based self‐locking MN for precise skin insertion, adhesion, and transcutaneous microdose is presented. The consists sharp skin‐penetrating tip, wide interlocking body, narrow base mechanical supports over flexible hydrocolloid patch improve accuracy penetration into irregular surfaces. Melanoma, type cancer, selected as model investigation MNs its uneven surface. In vivo immunotherapy efficacy evaluated by integrating SD‐208, transforming growth factor‐β (TGF‐β) inhibitor that suppresses proliferation metastasis tumors, anti‐PD‐L1 ( PD‐L1 Ab), an immune checkpoint induces T cell‐mediated tumor cell death, comparing them intratumoral injection. Evaluation Ab)/SD‐208 effectiveness B16F10 melanoma‐bearing mice confirms improved dose compared

Language: Английский

Citations

46
Photothermal-triggered dendrimer nanovaccines boost systemic antitumor immunity DOI

Siyan Shen,

Yue Gao,

Zhijun Ouyang

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 355, P. 171 - 183

Published: Feb. 6, 2023

Language: Английский

Citations

30
Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy DOI Creative Commons
Zhonglei Wang, Liyan Yang

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107150 - 107150

Published: March 21, 2024

Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as viable alternative conventional cancer treatments that encounter drug resistance. Nanotechnology brought new advances in medicine shown great potential delivery treatment. For precise efficient therapeutic utilization of such tumor approach high spatiotemporal selectivity minimal invasiveness, carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination essential. Utilizing natural products foundation nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, well biocompatibility. The natural-product-based, carrier-free, NPs revealed excellent synergistic anticancer activity comparison free photosensitizers bioactive products, representing an favorable avenue improve efficacy. Herein, comprehensive summary current strategies representative application examples past decade (such paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, curcumin) therapy. We highlight insightful design synthesis smart aim enhance PDT Meanwhile, we discuss future challenges opportunities associated these provide enlightenment, spur innovative ideas, facilitate PDT-mediated clinical transformation.

Language: Английский

Citations

15
Application of Nanoparticles in the Treatment of Lung Cancer With Emphasis on Receptors DOI Creative Commons

Jingyue Wang,

Tong Zhou, Ying Liu

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 10, 2022

Lung cancer is one of the malignant tumors that has seen most rapid growth in terms morbidity and mortality recent years, posing biggest threat to people’s health lives. In nano-drug loading system made significant progress detection, diagnosis, treatment lung cancer. Nanomaterials are used specifically target tumor tissue minimize therapeutic adverse effects increase bioavailability. It achieved primarily through two mechanisms: passive targeting, which entails use enhanced penetration retention (EPR) effect, active recognition ligands for marker molecules onto nanomaterials. However, it been demonstrated EPR effect effective rodents but not humans. Taking this into consideration, researchers paid attention targeting system. Additionally, have a higher affinity specificity cells. review, describes development research targeted delivery systems from receptors’ or targets’ perspective. We anticipate study will help biomedical nanoparticles (NPs) treat by providing more novel drug strategies solid ligands.

Language: Английский

Citations

32
Emerging nanomedicines strategies focused on tumor microenvironment against cancer recurrence and metastasis DOI
Yi Feng, Zhen Liao, Hanxi Zhang

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 452, P. 139506 - 139506

Published: Oct. 1, 2022

Language: Английский

Citations

30
Developing a Gallium(III) Agent Based on the Properties of the Tumor Microenvironment and Lactoferrin: Achieving Two-Agent Co-delivery and Multi-targeted Combination Therapy of Cancer DOI

Tongfu Yang,

Zhenlei Zhang, Juzheng Zhang

et al.

Journal of Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 66(1), P. 793 - 803

Published: Dec. 22, 2022

To develop a next-generation anticancer metal-based drug, realize the multi-targeted combination therapy of protein drug and for cancer, solve their co-delivery challenges, improve in vivo targeting ability, we proposed to agent exploiting properties tumor microenvironment (TME) lactoferrin (LF). this end, optimized series gallium (Ga, III) isopropyl-2-pyridyl-ketone thiosemicarbazone compounds obtain Ga compound (C4) with remarkable cytotoxicity then constructed new LF-C4 nanoparticle (LF-C4 NP) delivery system. In studies showed that NPs not only had greater capacity inhibiting growth than LF or C4 alone but also solved problems improved ability. Furthermore, free inhibited through multiple synergistic actions on TME: killing cancer cell, angiogenesis, activating immune

Language: Английский

Citations

29
Nanoparticles overcome adaptive immune resistance and enhance immunotherapy via targeting tumor microenvironment in lung cancer DOI Creative Commons
Xin Zhang, Xuemei Wang, Lijian Hou

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 24, 2023

Lung cancer is one of the common malignant cancers worldwide. Immune checkpoint inhibitor (ICI) therapy has improved survival lung patients. However, ICI leads to adaptive immune resistance and displays PD-1/PD-L1 blockade in cancer, leading less response Tumor microenvironment (TME) an integral tumor microenvironment, which involved immunotherapy resistance. Nanomedicine been used enhance cancer. In this review article, we described association between TME We also highlighted importance Moreover, discussed how nanoparticles are regulation improve efficacy immunotherapy, including SGT-53, AZD1080, Nanomodulator NRF2, Cisplatin nanoparticles, Au@PG, DPAICP@ME, SPIO NP@M-P, NBTXR3 ARAC Nano-DOX, MS NPs, Nab-paclitaxel, GNPs-hPD-L1 siRNA. Furthermore, concluded that targeting by could be helpful overcome

Language: Английский

Citations

18
Drug-drug conjugates self-assembled nanomedicines triggered photo−/immuno- therapy for synergistic cancer treatments DOI

Haijing Qu,

Longmeng Li,

Han Chen

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 363, P. 361 - 375

Published: Sept. 29, 2023

Language: Английский

Citations

18
Recent Advances on Surface-Modified GBM Targeted Nanoparticles: Targeting Strategies and Surface Characterization DOI Open Access
Francesca Rodà, Riccardo Caraffi, Silvia Picciolini

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2496 - 2496

Published: Jan. 27, 2023

Glioblastoma multiforme (GBM) is the most common malignant brain tumor, associated with low long-term survival. Nanoparticles (NPs) developed against GBM are a promising strategy to improve current therapies, by enhancing delivery of active molecules and reducing off-target effects. In particular, NPs hold high potential for targeted chemotherapeutics both across blood–brain barrier (BBB) specifically cell receptors, pathways, or tumor microenvironment (TME). this review, recent strategies deliver drugs explored. The main focus on how surface functionalizations essential BBB crossing specific targeting. We give critical analysis various ligand-based approaches that have been used target cancer receptors TME, interfere signaling pathways GBM. Despite increasing application in clinical setting, new methods ligand characterization needed optimize synthesis, as well predict their vivo behavior. An expert opinion given future research what still missing create characterize functional NP system improved

Language: Английский

Citations

17