Biosensors,
Journal Year:
2022,
Volume and Issue:
12(2), P. 86 - 86
Published: Jan. 31, 2022
Monomodal
cancer
therapies
are
often
unsatisfactory,
leading
to
suboptimal
treatment
effects
that
result
in
either
an
inability
stop
growth
and
metastasis
or
prevent
relapse.
Thus,
synergistic
strategies
combine
different
therapeutic
modalities
improve
performance
have
become
the
new
research
trend.
In
this
regard,
integration
of
photothermal
therapy
(PTT)
with
chemodynamic
(CDT),
especially
PTT/CDT
second
near-infrared
(NIR-II)
biowindow,
has
been
demonstrated
be
a
highly
efficient
relatively
safe
concept.
With
rapid
development
nanotechnology,
nanoparticles
can
designed
from
specific
elements,
such
as
Fe,
equipped
both
PTT
CDT
functions.
review,
we
provide
update
on
recent
advances
Fe-based
nanoplatforms
for
combined
PTT/CDT.
The
perspectives
further
improvement
curative
efficiency
described,
highlighting
important
scientific
obstacles
require
resolution
order
reach
greater
heights
clinical
success.
We
hope
review
will
inspire
interest
researchers
developing
novel
nanomedicines
multifunctional
theranostics.
Journal of Materials Chemistry B,
Journal Year:
2021,
Volume and Issue:
10(1), P. 20 - 33
Published: Nov. 22, 2021
Chemotherapeutic
agents
have
been
used
for
the
treatment
of
numerous
cancers,
but
due
to
poor
selectivity
and
severe
systemic
side
effects,
their
clinical
application
is
limited.
Single-stranded
DNA
(ssDNA)
or
RNA
aptamers
could
conjugate
with
highly
toxic
chemotherapy
drugs,
toxins,
therapeutic
RNAs
other
molecules
as
novel
aptamer-drug
conjugates
(ApDCs),
which
are
capable
significantly
improving
efficacy
reducing
toxicity
drugs
great
potential
in
clinics
targeted
cancer
therapy.
In
this
review,
we
comprehensively
discussed
summarized
current
advances
screening
approaches
specific
biomarker
targeting
development
strategy
drug
delivery.
Moreover,
considering
huge
progress
artificial
intelligence
(AI)
protein
structure
predictions,
automatic
design
using
deep/machine
learning
techniques
be
a
powerful
approach
rapid
precise
construction
biopharmaceutics
(i.e.,
ApDCs)
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(8), P. 1606 - 1606
Published: Aug. 1, 2022
Clinically,
cancer
drug
resistance
to
chemotherapy,
targeted
therapy
or
immunotherapy
remains
the
main
impediment
towards
curative
therapy,
which
leads
directly
treatment
failure
along
with
extended
hospital
stays,
increased
medical
costs
and
high
mortality.
Therefore,
increasing
attention
has
been
paid
nanotechnology-based
delivery
systems
for
overcoming
in
cancer.
In
this
respect,
novel
tumor-targeting
nanomedicines
offer
fairly
effective
therapeutic
strategies
surmounting
various
limitations
of
immunotherapy,
enabling
more
precise
treatment,
convenient
monitoring
agents,
as
well
resistance,
including
multidrug
(MDR).
Nanotechnology-based
systems,
liposomes,
polymer
micelles,
nanoparticles
(NPs),
DNA
nanostructures,
enable
a
large
number
properly
designed
nanomedicines.
paper,
we
review
different
mechanisms
discuss
latest
developments
resistance.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 8621 - 8640
Published: Aug. 1, 2024
Berberine
(BBR),
recognized
as
an
oncotherapeutic
phytochemical,
exhibits
its
anti-cancer
properties
via
multiple
molecular
pathways.
However,
clinical
application
is
hindered
by
suboptimal
tumor
accumulation,
rapid
systemic
elimination,
and
diminished
bioactive
concentration
owing
to
extensive
metabolic
degradation.
To
circumvent
these
limitations,
the
strategic
employment
of
nanocarriers
other
drugs
in
combination
with
BBR
emerging
a
focus
potentiate
efficacy.
This
review
introduced
expansive
spectrum
BBR's
activities,
co-loaded
for
treatments,
evaluated
synergistic
augmentation
amalgamated
modalities.
The
aim
provide
overview
cancer
treatment
based
on
nano-delivery.
Nano-delivery
systems
increase
drug
at
site
improving
pharmacological
activity
tissue
distribution,
enhancing
bioavailability.
Organic
have
advantages
berberine
delivery
including
biocompatibility,
encapsulation,
controlled
release
drug.
While
inorganic
mainly
lie
their
efficient
loading
ability
slow
Biosensors,
Journal Year:
2022,
Volume and Issue:
12(2), P. 86 - 86
Published: Jan. 31, 2022
Monomodal
cancer
therapies
are
often
unsatisfactory,
leading
to
suboptimal
treatment
effects
that
result
in
either
an
inability
stop
growth
and
metastasis
or
prevent
relapse.
Thus,
synergistic
strategies
combine
different
therapeutic
modalities
improve
performance
have
become
the
new
research
trend.
In
this
regard,
integration
of
photothermal
therapy
(PTT)
with
chemodynamic
(CDT),
especially
PTT/CDT
second
near-infrared
(NIR-II)
biowindow,
has
been
demonstrated
be
a
highly
efficient
relatively
safe
concept.
With
rapid
development
nanotechnology,
nanoparticles
can
designed
from
specific
elements,
such
as
Fe,
equipped
both
PTT
CDT
functions.
review,
we
provide
update
on
recent
advances
Fe-based
nanoplatforms
for
combined
PTT/CDT.
The
perspectives
further
improvement
curative
efficiency
described,
highlighting
important
scientific
obstacles
require
resolution
order
reach
greater
heights
clinical
success.
We
hope
review
will
inspire
interest
researchers
developing
novel
nanomedicines
multifunctional
theranostics.
