PubMed,
Journal Year:
2023,
Volume and Issue:
43(8), P. 1432 - 1439
Published: Aug. 20, 2023
To
investigate
the
physicochemical
features
of
glucose
oxidase-loaded
and
manganese-based
mesoporous
silica
nanoparticles
(MSN@Mn-GOx)
its
antitumor
effect
against
gastrointestinal
cancer.The
morphology,
particle
size
Fenton-like
properties
MSN@Mn-GOx
were
analyzed
using
transmission
electron
microscopy
(TEM),
dynamic
light
scattering
(DLS),
Zeta
potential
analysis,
ultraviolet
absorption
spectroscopy,
energy
dispersive
spectroscopy
X-ray
photoelectron
spectroscopy.
A
mouse
model
bearing
human
colon
cancer
HT-29
xenograft
was
established
to
examine
MRI
imaging.
Reactive
oxygen
species
(ROS)
production
assay,
CCK-8
assay
EdU
used
evaluate
in
vitro
anti-tumor
nanoparticles.MSN@Mn-GOx
solid
spheres
with
a
diameter
about
100
nm
-35
mV.
had
higher
H2O2
catalytic
efficiency
containing
solution
than
glucose-free
solution,
showed
stronger
at
pH6.0
pH7.4
(P＜0.05).
In
tumor-bearing
mice,
treatment
dose-dependently
enhanced
T1
imaging
tumor
(P＜0.01).
Compared
control
group
MSN@Mn
group,
induced
significantly
level
ROS
inhibitory
on
proliferation
gastric
cells
(P＜0.05).MSN@Mn-GOx
have
good
chemodynamic
strong
provide
therapeutic
option
for
cancer.
Advanced Drug Delivery Reviews,
Journal Year:
2023,
Volume and Issue:
197, P. 114822 - 114822
Published: April 21, 2023
Central
nervous
system
(CNS)
disorders
affect
as
many
1.5
billion
people
globally.
The
limited
delivery
of
most
imaging
and
therapeutic
agents
into
the
brain
is
a
major
challenge
for
treatment
CNS
disorders.
With
advent
nanotechnologies,
controlled
drugs
with
nanoparticles
holds
great
promise
in
overcoming
blood-brain
barrier
(BBB)
improving
efficacy.
In
recent
years,
magnetic
iron
oxide
(MIONPs)
have
stood
out
promising
theranostic
nanoplatform
drug
they
possess
unique
physical
properties
biodegradable
characteristics.
this
review,
we
summarize
advances
MIONP-based
platforms
diseases.
We
firstly
introduce
methods
synthesis
surface
functionalization
MIONPs
emphasis
on
inclusion
biocompatible
polymers
that
allow
addition
tailored
physicochemical
properties.
then
discuss
vivo
applications
using
MIONPs.
Finally,
present
perspective
remaining
challenges
possible
future
directions
systems.
Biomaterials Research,
Journal Year:
2022,
Volume and Issue:
26(1)
Published: July 6, 2022
Theranostic
nanoplatforms
integrating
diagnostic
and
therapeutic
functions
have
received
considerable
attention
in
the
past
decade.
Among
them,
hollow
manganese
(Mn)-based
are
superior
since
they
combine
advantages
of
structures
intrinsic
theranostic
features
Mn
BME Frontiers,
Journal Year:
2023,
Volume and Issue:
4
Published: Jan. 1, 2023
The
wide
and
frequent
use
of
antibiotics
in
the
treatment
bacterial
infection
can
cause
occurrence
multidrug-resistant
bacteria,
which
becomes
a
serious
health
threat.
Therefore,
it
is
necessary
to
develop
antibiotic-independent
modalities.
Chemodynamic
therapy
(CDT)
defined
as
approach
employing
Fenton
and/or
Fenton-like
reactions
for
generating
hydroxyl
radical
(•OH)
that
kill
target
cells.
Recently,
CDT
has
been
successfully
employed
antibacterial
applications.
Apart
from
common
Fe-mediated
strategy,
strategies
mediated
by
other
metal
elements
such
copper,
manganese,
cobalt,
molybdenum,
platinum,
tungsten,
nickel,
silver,
ruthenium,
zinc
have
also
proposed.
Furthermore,
different
types
materials
like
nanomaterials
hydrogels
be
adopted
constructing
CDT-involved
platforms.
Besides,
introduce
some
toxic
then
achieve
synergistic
effects
together
with
reactive
oxygen
species.
Finally,
combined
therapies
starvation
therapy,
phototherapy,
sonodynamic
achieving
improved
performance.
This
review
first
summarizes
advancements
discusses
present
limitations
future
research
directions
this
field,
hoping
promote
development
more
effective
potentiated
CDT.
Materials Today Advances,
Journal Year:
2022,
Volume and Issue:
14, P. 100226 - 100226
Published: Feb. 23, 2022
Theranostic
nanoplatforms
combining
various
diagnostic
and
therapeutic
units
together
have
attracted
increasing
attention
over
the
past
few
decades.
Owing
to
merits
of
non-invasiveness,
spatiotemporal
controllability,
high
treatment
efficacy
low
normal-tissue
damage,
photothermal
therapy
(PTT)
especially
near-infrared-II
(NIR-II,
1000–1700
nm)
light-triggered
PTT
becomes
one
most
popular
modalities.
Interestingly,
agents
(PTAs)
used
for
often
an
intrinsic
photoacoustic
(PA)
imaging
function,
which
means
that
PTAs
alone
can
serve
as
all-in-one
theranostic
nanoplatforms.
With
rapid
development
nanomedicine,
a
single
agent
be
endowed
with
desirable
conversion
efficiency
(PCE)
in
NIR-II
biowindow
well
possessing
diverse
capabilities.
This
review
summarizes
recent
advances
inorganic
imaging-guided
PTT,
PTT/photodynamic
(PDT),
PTT/chemodynamic
(CDT),
PTT/radiotherapy
(RT),
PTT/sonodynamic
(SDT),
PTT/PDT/CDT
PTT/SDT/immunotherapy.
Potential
obstacles
perspectives
future
research
clinical
translation
such
novel
nanotheranostics
are
also
discussed.
Bioinorganic Chemistry and Applications,
Journal Year:
2022,
Volume and Issue:
2022(1)
Published: Jan. 1, 2022
Solid
tumors
have
a
unique
tumor
microenvironment
(TME),
which
includes
hypoxia,
low
acidity,
and
high
hydrogen
peroxide
glutathione
(GSH)
levels,
among
others.
These
factors,
offer
favourable
microenvironments
nourishment
for
development
spread,
also
serve
as
gateway
specific
successful
cancer
therapies.
A
good
example
is
metal
structures
been
synthesized
utilized
to
enhance
oxygen
supply
they
shown
great
promise
in
the
alleviation
of
hypoxia.
In
hypoxic
environment,
certain
oxygen‐dependent
treatments
such
photodynamic
therapy
radiotherapy
fail
respond
therefore
modulating
has
found
antitumor
impact
drugs.
Under
acidic
environments,
produced
by
reaction
peroxides
with
water
not
only
induces
oxidative
stress
but
produces
additional
oxygen.
This
achieved
since
acts
reactive
substrate
molecules
catalyse
enzymes,
alleviating
hypoxia
observed
microenvironment.
Metal
ions
released
process
can
distinct
bioactivity
their
own
right.
used
anticancer
are
rapidly
evolving
field,
there
evidence
that
option
regulating
therapy.
this
regard,
synthesis
mechanisms
behind
application
specifically
target
highlighted
review.
Various
characteristics
TME
angiogenesis,
inflammation,
acidity
ion
homeostasis
addressed
together
forms
synergistic
combination
treatments.
Advanced Optical Materials,
Journal Year:
2023,
Volume and Issue:
11(8)
Published: Feb. 8, 2023
Abstract
I‐III‐VI
2
semiconductor
nanocrystals
have
been
explored
in
countless
optoelectronics
and
green
energy
applications.
While
indium‐based
compounds
are
arguably
the
best‐known
variants
of
these
semiconductors
widely
studied
for
their
photophysical
properties,
other
emerging
as
serious
competitors.
This
review
focuses
on
current
state
art
recent
progress
made
research
technology
one
most
promising
competitors
to
nanocrystals,
CuFeS
nanocrystals.
is
a
alternative
systems,
mostly
because
many
properties
competitive
iron
much
more
abundant
than
indium.
Replacing
In(III)
with
Fe(III)
would
thus
significantly
alleviate
issue
raw
material
availability.
The
article
highlights
new
synthesis
approaches
summarizes
discusses
advanced
optical
including
surface
plasmon
resonance
luminescence
properties.
Moreover,
potential
applications
thermoelectric,
photodetection,
photothermal,
photovoltaics
illustrated
discussed.
Finally,
future
perspectives
materials
development,
upscaling,
application
processes
devices,
such
self‐assembly,
patterning,
or
plasmonic
catalysis,
presented
well.
