Metal‐Free Atom Transfer Radical Polymerization to Prepare Recylable Micro‐Adjuvants for Dendritic Cell Vaccine DOI

Hengyuan Zhang,

Xingyu Heng,

Yang He

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(24)

Published: April 10, 2024

In the development of dendritic cell (DC) vaccines, maturation DCs is a critical stage. Adjuvants play pivotal role in DCs, with major concern being to ensure both efficacy and safety. This study introduces an innovative approach that combines high safety through synthesis micro-adjuvants grafted copolymers 2-(methacrylamido) glucopyranose (MAG) methacryloxyethyl trimethyl ammonium chloride (DMC). The utilization metal-free surface-initiated atom transfer radical polymerization enables production safe recyclable adjuvants. These micrometer-sized adjuvants surpass optimal size range for cellular endocytosis, enabling retrieval reuse them during ex vivo process, mitigating potential toxicity concerns associated endocytosis non-metabolized nanoparticles. Additionally, exhibit "micro-ligand-mediated enhancement" effect DC maturation. influenced by shape particle, as evidenced distinct promotion effects rod-like spherical comparable sizes. Furthermore, porous structure function cargo-carrying "micro-shuttles", releasing antigens upon binding facilitate efficient antigen delivery.

Language: Английский

Engineering customized nanovaccines for enhanced cancer immunotherapy DOI Creative Commons

JinYu Guo,

Changhua Liu, Zhaoyang Qi

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 330 - 357

Published: March 11, 2024

Nanovaccines have gathered significant attention for their potential to elicit tumor-specific immunological responses. Despite notable progress in tumor immunotherapy, nanovaccines still encounter considerable challenges such as low delivery efficiency, limited targeting ability, and suboptimal efficacy. With an aim of addressing these issues, engineering customized through modification or functionalization has emerged a promising approach. These tailored not only enhance antigen presentation, but also effectively modulate immunosuppression within the microenvironment. Specifically, they are distinguished by diverse sizes, shapes, charges, structures, unique physicochemical properties, along with ligands. features facilitate lymph node accumulation activation/regulation immune cells. This overview bespoke underscores both prophylactic therapeutic applications, offering insights into future development role cancer immunotherapy.

Language: Английский

Citations

12
Seizing the fate of lymph nodes in immunotherapy: To preserve or not? DOI
Zhenyu Xu, Zi‐Zhan Li, Lei‐Ming Cao

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216740 - 216740

Published: Feb. 27, 2024

Language: Английский

Citations

11
Application of biomimetic nanovaccines in cancer immunotherapy: A useful strategy to help combat immunotherapy resistance DOI
Zhijie Xu,

Zhou Hai-yan,

Tongfei Li

et al.

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 75, P. 101098 - 101098

Published: June 1, 2024

Language: Английский

Citations

10
Exploring the immuno-nano nexus: A paradigm shift in tumor vaccines DOI Open Access
Yuanyuan Li, Yuxing Xu,

Wenwen Su

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117897 - 117897

Published: Feb. 7, 2025

Language: Английский

Citations

1
Programmed T cells infiltration into lung metastases with harnessing dendritic cells in cancer immunotherapies by catalytic antigen-capture sponges DOI

Min‐Ren Chiang,

Wei‐Ting Shen,

Pin‐Xuan Huang

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 360, P. 260 - 273

Published: June 29, 2023

Language: Английский

Citations

17
Elaborately engineering of lipid nanoparticle for targeting delivery of siRNA and suppressing acute liver injury DOI
Qiu Wang, Qikun Jiang, Dan Li

et al.

Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 35(2), P. 108683 - 108683

Published: June 17, 2023

Language: Английский

Citations

16
Poria cocos polysaccharide—functionalized graphene oxide nanosheet induces efficient cancer immunotherapy in mice DOI Creative Commons

Jinning Yang,

Xiaoxiao Dong,

Boye Li

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 10

Published: Jan. 16, 2023

Introduction: Tumor vaccines that induce robust humoral and cellular immune responses have attracted tremendous interest for cancer immunotherapy. Despite the potential of tumor as an effective approach treatment prevention, a major challenge in achieving sustained antitumor immunity is inefficient antigen delivery to secondary lymphoid organs, even with adjuvant aid. Methods: Herein, we present antigen/adjuvant integrated nanocomplexes termed nsGO/PCP/OVA by employing graphene oxide nanosheet (nsGO) nanocarriers loaded model ovalbumin (OVA) adjuvant, Poria cocos polysaccharides (PCP). We evaluated efficacy activating antigen-specific well consequent prevention rejection vivo . Results: The optimally formed was approximately 120–150 nm diameter uniform size distribution. Nanoparticles can be effectively engulfed dendritic cells (DCs) through receptor-mediated endocytosis, induced maturation DCs improved efficiency both vitro vivo. nanoparticles also significant enhancement OVA Th1 Th2 In addition, vaccination not only significantly suppressed growth prophylactic treatments, but achieved therapeutic effect inhibiting already-established tumors. Conclusion: Therefore, this potent nanovaccine platform nanocarrier nsGO PCP adjuvants provides promising strategy boosting anti-tumor

Language: Английский

Citations

15
Nanotheranostics in cancer lymph node metastasis: The long road ahead DOI Creative Commons

Kan Zhou,

Zi‐Zhan Li,

Ze‐Min Cai

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 198, P. 106989 - 106989

Published: Nov. 17, 2023

Lymph node metastasis (LNM) significantly impacts the prognosis of cancer patients. Despite significant advancements in diagnostic techniques and treatment modalities, clinical challenges continue to persist realm LNM. These include difficulties early diagnosis, limited efficacy, potential side effects injuries associated with treatment. Nanotheranostics, a field within nanotechnology, seamlessly integrates therapeutic functionalities. Its primary goal is provide precise effective disease diagnosis simultaneously. The development nanotheranostics for LNM offers promising solution stratified management patients promotes advancement personalized medicine. This review introduces mechanisms its Furthermore, it demonstrates advantages nanotheranostics, focuses on face application, provides an outlook future trends. We consider strategy improve effectiveness efficiency as well

Language: Английский

Citations

14
The future of cancer vaccines against colorectal cancer DOI
Wenqing Jia,

Xiaonan Shen,

Zichao Guo

et al.

Expert Opinion on Biological Therapy, Journal Year: 2024, Volume and Issue: 24(4), P. 269 - 284

Published: April 2, 2024

Introduction Colorectal cancer (CRC) is the second most lethal malignancy worldwide. Immune checkpoint inhibitors (ICIs) benefit only 15% of patients with mismatch repair-deficient/microsatellite instability (dMMR/MSI) CRC. The majority are not suitable due to insufficient immune infiltration. Cancer vaccines a potential approach for inducing tumor-specific immunity within solid tumor microenvironment.

Language: Английский

Citations

5
Engineering dendritic cell biomimetic membrane as a delivery system for tumor targeted therapy DOI Creative Commons
Huiyang Liu,

Yiming Lu,

Jinbao Zong

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 27, 2024

Targeted immunotherapies make substantial strides in clinical cancer care due to their ability counteract the tumor's capacity suppress immune responses. Advances biomimetic technology with minimally immunogenic and highly targeted, are addressing issues of targeted drug delivery disrupting immunosuppressive environment trigger activation. Specifically, use dendritic cell (DC) membranes coat nanoparticles ensures DC's unique activate naive T cells, spotlighting role immunotherapy aimed at tumor microenvironment. The potential membrane mediate activation target tumors is gaining momentum, enhancing effectiveness treatments conjunction other This review delves into methodologies behind crafting DC fusion for encapsulating therapeutic nanoparticles. It explores applications recent advancements combating cancer, offering an all-encompassing perspective on nanosystems, driven by antigen presentation, collaborative efforts chemotherapy photodynamic therapies. Current evidence shows promise augmenting combined approaches treatment holds translational various a setting.

Language: Английский

Citations

4