Science Advances,
Journal Year:
2024,
Volume and Issue:
10(35)
Published: Aug. 28, 2024
Despite
the
therapeutic
benefits
of
insulin-pramlintide
dual-hormone
therapy
in
diabetes,
its
application
potential
has
been
limited
due
to
a
lack
efficient
delivery
routes.
Here,
we
developed
temperature-responsive
foam
nanoengine
(HormFoam)
and
combined
it
with
customized
spraying
device
further
construct
an
situ
foam-generating
system
for
improving
rectal
bioavailability
therapy.
To
support
rapid
clinical
translation,
continuous
microfluidic
preparation
HormFoam
was
proposed,
including
power
unit
perfluorocarbon
nanodroplets
pharmaceutical
components
Pluronic
F127-functionalized
liposomal
insulin
pramlintide.
We
found
that
could
consistently
generate
foams
drive
drugs
forward
after
administration,
which
enhanced
intestinal
distribution
mucosa
absorption,
leading
systemic
codelivery
insulin-pramlintide.
reproduced
physiology
endocrine
pancreas
glycemic
control
induced
body
weight
loss
while
reversing
metabolic
disorders
diabetic
mice
good
biosafety.
Therefore,
represents
state-of-the-art
regimen
address
unmet
needs
diabetes
management.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(15), P. 8825 - 9014
Published: July 25, 2024
Luminescence
imaging
is
a
powerful
and
versatile
technique
for
investigating
cell
physiology
pathology
in
living
systems,
making
significant
contributions
to
life
science
research
clinical
diagnosis.
In
recent
years,
luminescent
transition
metal
complexes
have
gained
attention
diagnostic
therapeutic
applications
due
their
unique
photophysical
photochemical
properties.
this
Review,
we
provide
comprehensive
overview
of
the
development
bioimaging
biosensing
applications,
with
focus
on
centers
d
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(48)
Published: July 18, 2024
Abstract
Two‐photon
excitation
(2PE)
represents
substantial
advantages
in
biophotonics
over
traditional
one‐photon
(1PE),
offering
enhanced
spatial
resolution
and
deeper
tissue
penetration
capabilities.
Since
its
introduction
the
1990s,
two‐photon
excited
microscopy
has
spurred
rapid
emergence
of
novel
2PE‐based
applications,
including
photodynamic
therapy
(PDT)
targeted
release
biologically
active
agents.
This
review
first
elucidates
fundamental
principles
2PE
before
comprehensively
examining
evolution
photosensitizers
(PSs)
for
PDT
(2P‐PDT),
covering
both
nanomaterials
small
molecules,
categorized
based
on
their
respective
characteristics.
Additionally,
it
explores
advancements
PS
development
integrating
2P‐PDT
with
other
therapeutic
modalities
(e.g.,
photothermal
therapy,
chemotherapy,
immunotherapy,
gene
etc.).
Subsequent
sections
provide
an
overview
photoactivatable
compounds
absorption
properties
controlled
various
agents
drugs,
genes,
gasotransmitters),
emphasizing
potential
anticancer
applications.
Last,
a
deep
discussion
deciphers
prospects
challenges
2P‐mediated
cancer
treatment,
particularly
concerning
clinical
translation.
Journal of Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
66(21), P. 14583 - 14596
Published: Nov. 1, 2023
Carbon
monoxide
has
shown
promise
as
a
therapeutic
agent
against
cancers.
Reactive
oxygen
species
(ROS)-activated
CO
prodrugs
are
highly
demanded
for
targeted
cancer
treatment
but
remain
sporadic.
In
addition,
little
attention
is
on
how
the
release
rate
affects
CO's
biological
effects.
Herein,
we
describe
new
type
of
ROS-activated
metal-free
prodrug,
which
releases
with
tunable
rates
in
response
to
multiple
ROS
and
exhibits
very
pronounced
tumor
suppression
effects
mouse
4t1
breast
model.
Importantly,
first
time,
observe
both
vitro
vivo
that
direct
impact
its
antiproliferative
potency
correlation
between
activity
observed.
aggregates,
our
results
not
only
deliver
ROS-sensitive
also
represent
promising
starting
point
further
in-depth
studies
kinetics
affect
anticancer
activity.
Journal of Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
66(24), P. 16546 - 16567
Published: Dec. 12, 2023
Time-
and
space-resolved
drug
delivery
is
highly
demanded
for
cancer
treatment,
which,
however,
can
barely
be
achieved
with
a
traditional
prodrug
strategy.
In
recent
years,
the
strategy
based
on
bioorthogonal
bond
cleavage
chemistry
has
emerged
advantages
of
high
temporospatial
resolution
over
activation
homogeneous
irrespective
individual
heterogeneity.
past
five
tremendous
progress
been
witnessed
in
this
field
one
such
entering
Phase
II
clinical
trials.
This
Perspective
aims
to
highlight
these
new
advances
(2019–2023)
critically
discuss
their
pros
cons.
addition,
remaining
challenges
potential
strategic
directions
future
will
also
included.
Chemical & Biomedical Imaging,
Journal Year:
2024,
Volume and Issue:
2(6), P. 401 - 412
Published: April 1, 2024
Biological
gasotransmitters
(small
molecules
of
gases)
play
important
roles
in
signal
transduction
mechanisms
and
disease
treatments.
Although
a
large
number
small-molecule
donors
have
been
developed,
visualizing
the
release
small
remains
challenging.
Owing
to
their
unique
optical
properties,
fluorophores
widely
applied
cellular
imaging
tracking.
Researchers
used
various
develop
with
fluorescent
activity
for
related
therapies.
These
include
derivatives
such
as
boron-dipyrromethene
(BODIPY),
coumarin,
1,8-naphthalimide,
hemicyanine,
porphyrin,
rhodamine,
fluorescein.
In
this
review,
we
summarize
design
concepts
functional
terms
different
types
fluorophores.
Then,
discuss
how
these
molecules,
modalities
biomedical
applications
facilitated
by
properties.
With
systematic
discussion
publications,
hope
provide
useful
references
development
more
practical,
advanced
future.
