International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 5931 - 5949
Published: June 1, 2024
Abstract:
The
self-assembling
aggregated
structures
of
natural
products
have
gained
significant
interest
due
to
their
simple
synthesis,
lack
carrier-related
toxicity,
and
excellent
biological
efficacy.
However,
the
mechanisms
assembly
ability
traverse
gastrointestinal
(GI)
barrier
remain
unclear.
This
review
summarizes
various
intermolecular
non-covalent
interactions
structures,
drawing
on
research
indexed
in
Web
Science
from
2010
2024.
Cheminformatics
analysis
self-assembly
behaviors
small
molecules
supramolecular
aggregates
reveals
assembly-favorable
conditions,
aiding
drug
formulation.
Additionally,
explores
properties
macromolecules
like
polysaccharides,
proteins,
exosomes,
highlighting
role
delivery.
Strategies
overcome
barriers
enhance
bioavailability
are
also
discussed.
work
underscores
potential
oral
delivery
offers
insights
for
designing
more
effective
systems.
Keywords:
products,
self-assembly,
supramolecules,
delivery,
Artificial Cells Nanomedicine and Biotechnology,
Journal Year:
2024,
Volume and Issue:
52(1), P. 564 - 586
Published: Dec. 5, 2024
Cancer
has
a
high
rate
of
incidence
and
mortality
throughout
the
world.
Although
several
conventional
approaches
have
been
developed
for
treatment
cancer,
such
as
surgery,
chemotherapy,
radiotherapy
thermal
therapy,
they
remarkable
disadvantages
which
result
in
inefficient
cancer.
For
example,
immunogenicity,
prolonged
treatment,
non-specificity,
metastasis
cost
are
considered
major
drawbacks
chemotherapy.
Therefore,
there
is
fundamental
requirement
development
breakthrough
technologies
cancer
suppression.
Polysaccharide-based
drug
delivery
systems
(DDSs)
most
reliable
carriers
therapy.
Polysaccharides,
kind
practical
biomaterials,
divided
into
types,
including
chitosan,
alginates,
dextran,
hyaluronic
acid,
cyclodextrin,
pectin,
etc.
Polysaccharides
extracted
from
different
natural
resources
(like
herbal,
marine,
microorganisms,
etc.).
The
potential
features
polysaccharides
made
them
candidates
therapeutics
to
sites;
simple
purification,
ease
modification
functionalization,
hydrophilicity,
serum
stability,
appropriate
loading
capacity,
biocompatibility,
bioavailability,
biodegradability
stimuli-responsive
sustained
release
manner
considerable
aspects
these
biopolymers.
This
review
highlights
applications
polysaccharides-based
DDSs
pharmaceutical
science
Materials,
Journal Year:
2023,
Volume and Issue:
16(24), P. 7550 - 7550
Published: Dec. 7, 2023
"Green"
strategies
to
build
up
novel
organic
nanocarriers
with
bioperformance
are
modern
trends
in
nanotechnology.
In
this
way,
the
valorization
of
bio-wastes
and
use
living
systems
develop
multifunctional
biogenic
(OBNs)
have
revolutionized
nanotechnological
biomedical
fields.
This
paper
is
a
comprehensive
review
related
OBNs
for
bioactives'
delivery,
providing
an
overview
reports
on
past
two
decades.
first
part,
several
classes
bioactive
compounds
their
therapeutic
role
briefly
presented.
A
broad
section
dedicated
main
categories
nanocarriers.
The
major
challenges
regarding
eco-design
fate
suggested
overcome
some
toxicity-related
drawbacks.
Future
directions
opportunities,
finding
"green"
solutions
solving
problems
nanocarriers,
outlined
final
paper.
We
believe
that
through
review,
we
will
capture
attention
readers
open
new
perspectives
solutions/ideas
discovery
more
efficient
ways
developing
bioperformant
transporting
agents.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(1), P. 88 - 88
Published: Jan. 9, 2024
Clinical
drug
administration
aims
to
deliver
drugs
efficiently
and
safely
target
tissues,
organs,
cells,
with
the
objective
of
enabling
their
therapeutic
effects.
Currently,
main
approach
enhance
a
drug’s
effectiveness
is
ensuring
its
efficient
delivery
intended
site.
Due
fact
that
there
are
still
various
drawbacks
traditional
methods,
such
as
high
toxicity
side
effects,
insufficient
specificity,
poor
targeting,
pharmacokinetic
performance,
nanocarriers
have
emerged
promising
alternative.
Nanocarriers
possess
significant
advantages
in
due
size
tunability
surface
modifiability.
Moreover,
nano-drug
systems
demonstrated
strong
potential
terms
prolonging
circulation
time,
improving
bioavailability,
increasing
retention
at
tumor
site,
decreasing
resistance,
well
reducing
undesirable
effects
anticancer
drugs.
Numerous
studies
focused
on
utilizing
polysaccharides
nanodelivery
carriers,
developing
based
polysaccharides,
or
exploiting
tumor-targeting
ligands
precision
nanoparticle
delivery.
These
types
investigations
become
commonplace
academic
literature.
This
review
elucidate
preparation
methods
principles
polysaccharide
gold
nanocarriers.
It
also
provides
an
overview
factors
affect
loading
different
kinds
Additionally,
it
outlines
strategies
employed
by
improve
efficiency
The
provide
reference
for
further
development
research
systems.
Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
95(40), P. 15068 - 15077
Published: Sept. 28, 2023
Fluorescence
imaging
can
improve
surgical
accuracy
in
ovarian
cancer,
but
a
high
signal-to-noise
ratio
is
crucial
for
tiny
metastatic
cancers.
Meanwhile,
intraoperative
fluorescent
navigation
modalities
alone
are
still
insufficient
to
completely
remove
cancer
lesions,
and
the
recurrence
rate
remains
high.
Here,
we
constructed
cancer-associated
fibroblasts
(CAFs)-mimetic
aggregation-induced
emission
(AIE)
probe
enable
full-cycle
management
of
surgery
that
eliminates
recurrence.
AIE
molecules
(P3-PPh3)
were
packed
hollow
mesoporous
silica
nanoparticles
(HMSNs)
form
HMSN-probe
then
coated
with
CAFs
membrane
prepare
CAF-probe.
First,
due
negative
potential
CAF-probe,
circulation
time
vivo
elevated,
which
facilitates
passive
tumor
targeting.
Second,
CAF-probe
avoids
its
clearance
by
immune
system
improves
bioavailability.
Finally,
fibronectin
on
specifically
binds
integrin
α-5
(ITGA5),
highly
expressed
cells,
enabling
fluorescence
contrast
up
8.6.
CAF-probe-based
used
evaluate
size
location
before
(preoperative
evaluation),
guide
removal
during
(intraoperative
navigation),
monitor
after
(postoperative
monitoring),
ultimately
significantly
improving
efficiency
eliminating
In
conclusion,
mimetic
established
model
based
precise
properties,
reduced
cancer.
Macromolecular Bioscience,
Journal Year:
2024,
Volume and Issue:
24(5)
Published: Jan. 23, 2024
Abstract
Combination
chemotherapy
is
considered
an
effective
strategy
to
inhibit
tumor
growth.
Here,
beta‐sheet‐rich
silk
nanofibers
are
co‐loaded
with
hydrophilic
doxorubicin
(DOX)
and
hydrophobic
paclitaxel
(PTX)
through
a
sequential
physical
blending‐centrifugation‐blending
process.
The
ratio
amount
of
DOX
PTX
on
the
regulated
independently
optimize
cooperative
interaction.
Both
immobilized
same
avoid
burst
release
problems.
Besides
water‐insoluble
PTX,
more
than
half
remained
fixed
for
28
days,
which
facilitated
co‐internalization
both
by
cells
in
vitro.
Changing
achieved
optimal
combination
therapy
DOX‐PTX
assembled
into
injectable
hydrogels
facilitate
situ
injection
around
tissues
vivo.
Long‐term
inhibition
tumors
treated
hydrogels,
superior
those
free
loaded
only
or
PTX.
Considering
mild
controllable
loading
process
capacity
ingredients,
these
nanofiber
promising
carriers
deliver
multiple
drug
types
simultaneously
situ,
enhancing
chemotherapies
towards
clinical
applications.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(15), P. 11587 - 11616
Published: Jan. 1, 2025
Iron-oxide
nanoparticles
(IONPs)
have
garnered
substantial
attention
in
both
research
and
technological
domains
due
to
their
exceptional
chemical
physical
properties.
