Gels,
Journal Year:
2023,
Volume and Issue:
9(8), P. 662 - 662
Published: Aug. 17, 2023
Smart-responsive
hydrogels
have
been
widely
used
in
various
fields,
particularly
the
biomedical
field.
Compared
with
traditional
hydrogels,
smart-responsive
not
only
facilitate
encapsulation
and
controlled
release
of
drugs,
active
substances,
even
cells
but,
more
importantly,
they
enable
on-demand
controllable
drugs
substances
at
disease
site,
significantly
enhancing
efficacy
treatment.
With
rapid
advancement
biomaterials,
received
widespread
attention,
a
wide
variety
developed
for
treatment
different
diseases,
thus
presenting
tremendous
research
prospects.
This
review
summarizes
latest
advancements
Additionally,
some
current
shortcomings
strategies
to
address
them
are
discussed,
as
well
future
development
directions
prospects
hydrogels.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(38)
Published: April 21, 2024
Abstract
Persistent
oxidative
stress
and
bacterial
infection
are
significant
challenges
that
impede
diabetic
wound
healing.
By
combining
diagnosis
treatment,
pH
variation
on
the
tissue
can
be
monitored
in
real
time,
precise
treatment
carried
out
promptly
to
promote
In
this
study,
a
lipoic
acid‐modified
chitosa
(LAMC)
hydrogel
is
constructed
via
an
amidation
reaction,
ceria
oxide‐molybdenum
disulfide
nanoparticles
with
polydopamine
layer
(C@M@P),
along
carbon
quantum
dots
(CDs)
synthesized
by
hydrothermal
method,
loaded
into
hydrogel,
thus
developing
diagnostic
therapeutic
(LAMC/CD‐C@M@P).
incorporating
CDs,
exhibits
high
sensitivity
reversibility
under
ultraviolet
light.
Furthermore,
images
of
hydrogels
collected
using
smartphones
converted
signals,
providing
means
for
early
detection
infection.
Notably,
LAMC/CD‐C@M@P
excellent
photothermal
antibacterial
capability
against
Staphylococcus
aureus
Escherichia
coli
remarkable
antioxidant
anti‐inflammatory
abilities
alleviate
reactive
oxygen
species
relieve
inflammation
response.
summary,
multifunctional
offers
great
potential
as
innovative
dressing
platform,
representing
advancement
chronic
management.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Feb. 5, 2024
Diabetic
wounds
are
a
significant
subset
of
chronic
characterized
by
elevated
levels
inflammatory
cytokines,
matrix
metalloproteinases
(MMPs),
and
reactive
oxygen
species
(ROS).
They
also
associated
with
impaired
angiogenesis,
persistent
infection,
high
likelihood
hospitalization,
leading
to
substantial
economic
burden
for
patients.
In
severe
cases,
amputation
or
even
mortality
may
occur.
foot
ulcers
(DFUs)
common
complication
diabetes,
up
25%
diabetic
patients
being
at
risk
developing
over
their
lifetime,
more
than
70%
ultimately
requiring
amputation.
Electrospun
scaffolds
exhibit
structural
similarity
the
extracellular
(ECM),
promoting
adhesion,
growth,
migration
fibroblasts,
thereby
facilitating
formation
new
skin
tissue
wound
site.
The
composition
size
electrospun
can
be
easily
adjusted,
enabling
controlled
drug
release
through
fiber
structure
modifications.
porous
nature
these
facilitates
gas
exchange
absorption
exudate.
Furthermore,
surface
readily
modified
impart
specific
functionalities,
making
electrospinning
nanofiber
highly
promising
treatment
wounds.
This
article
provides
concise
overview
healing
process
in
normal
pathological
mechanisms
underlying
wounds,
including
complications
such
as
ulcers.
It
explores
advantages
treatment.
Additionally,
it
summarizes
findings
from
various
studies
on
use
different
types
reviews
methods
loading
onto
scaffolds.
These
advancements
broaden
horizon
effectively
treating
Advanced Drug Delivery Reviews,
Journal Year:
2024,
Volume and Issue:
210, P. 115342 - 115342
Published: May 24, 2024
Chronic
non-healing
wounds
persist
as
a
substantial
burden
for
healthcare
systems,
influenced
by
factors
such
aging,
diabetes,
and
obesity.
In
contrast
to
the
traditionally
pro-regenerative
emphasis
of
therapies,
recognition
immune
system
integral
role
in
wound
healing
has
significantly
grown,
instigating
an
approach
shift
towards
immunological
processes.
Thus,
this
review
explores
process,
highlighting
engagement
system,
delving
into
behaviors
innate
adaptive
cells
chronic
scenarios.
Moreover,
article
investigates
biomaterial-based
strategies
modulation
elucidating
how
adjustment
their
physicochemical
properties
or
synergistic
combination
with
other
agents
drugs,
proteins
mesenchymal
stromal
can
effectively
modulate
different
cells.
Finally
various
based
on
synthetic
biological
nanostructures,
including
extracellular
vesicles,
finely
tune
natural
immunomodulators
therapeutic
nanocarriers
promising
biophysical
properties.
BMEMat,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Abstract
Chronic
wounds
are
that
difficult
to
heal
or
do
not
follow
the
normal
healing
process.
These
include
pressure
ulcers,
diabetic
venous
and
arterial
incomplete
ulcers.
Unlike
acute
wounds,
chronic
often
even
heal.
Its
pathogenesis
involves
many
factors;
bacterial
infection
is
main
cause
of
wound.
With
increase
in
population
aging,
incidence
has
become
a
critical
issue
current
medical
health
field.
Management
faced
with
problems
long
treatment
time,
difficulty,
high
cost,
repeated
attacks
disability
rate,
which
seriously
threaten
patients'
ability
take
care
themselves
life
heavy
burden
individuals,
families
society.
Over
past
few
years,
development
antibacterial
hydrogels
for
infections
received
lot
attention.
Since
only
have
mechanical
properties
hydrogels,
biocompatibility
adjustable
functional
structure,
but
also
excellent
properties,
they
may
be
an
ideal
dressing
solve
problem
wound
healing.
This
article
introduces
types
their
characteristics,
challenges
treating
wounds.
It
classifies
antimicrobial
based
on
modes
further
discusses
advancements
smart
along
benefits
obstacles
using
explores
directions
management.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(11)
Published: Dec. 27, 2023
Abstract
Treatment
of
diabetic
wounds
is
a
significant
clinical
challenge
due
to
the
massive
infections
caused
by
bacteria.
In
this
study,
multifunctional
glycol
chitosan
and
polydopamine‐coated
BiO
1‐x
I
(GPBO)
nanoparticles
(NPs)
with
near‐infrared
(NIR)
photothermal
photocatalytic
abilities
are
prepared.
When
infection
occurs,
local
microenvironment
becomes
acidic,
pH‐switchable
GPBO
can
target
bacteria
wound
site.
The
NIR‐assisted
treatment
exhibits
anti‐bacterial
effects
fast
response,
high
efficiency,
long
duration
Escherichia
coli,
Pseudomonas
aeruginosa
,
Staphylococcus
aureus
.
achieves
excellent
imaging
CT
mouse
subcutaneous
abscess
model.
With
assistance
NIR
irradiation,
promotes
healing
model
anti‐bacteria,
anti‐inflammation,
M2
polarization
promotion
macrophages,
angiogenesis.
This
first‐time
report
nano‐sized
I.
synthesis
selected
application
for
targeted
therapy
presented.
study
offers
an
example
NP‐assisted
precise
diagnosis
bacterial
diseases.
