Published: Jan. 1, 2025
Language: Английский
Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1822 - 1822
Published: Aug. 11, 2024
The increase in the variety of nano-based tools offers new possibilities to approach therapy poorly treatable tumors, which includes glioblastoma multiforme (GBM; a primary brain tumor). available nanocomplexes exhibit great potential as vehicles for targeted delivery anti-GBM compounds, including chemotherapeutics, nucleic acids, and inhibitors. main advantages nanoparticles (NPs) include improved drug stability, increased penetration blood-brain barrier, better precision tumor targeting. Importantly, alongside their drug-delivery ability, NPs may also present theranostic properties, applications imaging or photothermal malignant cells. can be classified into two categories according core, metal non-metal based. Among NPs, most studied regard GBM treatment are exosomes, liposomes, cubosomes, polymeric micelles, dendrimers, nanogels, carbon nanotubes, silica- selenium-based NPs. They characterized by satisfactory stability biocompatibility, limited toxicity, high accumulation tissue. Moreover, they easily functionalized cargo Therefore, discussed here, offer promising improving outcomes aggressive tumors.
Language: Английский
Citations
5
Cancers, Journal Year: 2024, Volume and Issue: 16(19), P. 3300 - 3300
Published: Sept. 27, 2024
Glioblastoma (GBM) is a prevalent type of malignancy within the central nervous system (CNS) that associated with poor prognosis. The standard treatment for GBM includes surgical resection tumor, followed by radiotherapy and chemotherapy; yet, despite these interventions, overall outcomes remain suboptimal. blood–brain barrier (BBB), which plays crucial role in maintaining stability brain tissue under normal physiological conditions CNS, also poses significant obstacle to effective delivery therapeutic agents GBMs. Recent preclinical studies have demonstrated nanomedicine systems (NDDSs) offer promising results, demonstrating both targeting safety, thereby presenting potential solution targeted drug delivery. In this review, we first explore various strategies employed overcome BBB Subsequently, results clinical translation NDDSs are summarized, highlighting progress made. Finally, discuss advancing development accelerating their translational research through well-designed trials therapy.
Language: Английский
Citations
5
Romanian Journal of Morphology and Embryology, Journal Year: 2024, Volume and Issue: 65(2), P. 173 - 184
Published: July 15, 2024
Over the last decades, silica nanoparticles (SiNPs) have been studied for their applications in biomedicine as an alternative used conventional diagnostics and treatments. Since properties can be modified adjusted desired use, they many different potential medicine: diagnosis because of ability to loaded with dyes increased selectivity sensitivity, which improve quality diagnostic process. SiNPs functionalized by targeting ligands or molecules detect certain cellular processes biomarkers better precision. Targeted delivery is another fundamental use SiNPs. They could drug systems (DDS) since structure allows loading therapeutic agents other compounds, studies demonstrated biocompatibility. When are DDS, drug’s toxicity off-target effects reduced significantly, treat conditions like cancer neurological diseases even aid regenerative processes, such wound healing bone repair. However, safety concerns must considered before extensively clinical practice NPs cause accumulate at undesired locations. Therefore, overview that medicine, well concerns, will covered this review paper.
Language: Английский
Citations
4
ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: 8(2), P. 543 - 556
Published: Jan. 6, 2025
Cannabidiol (CBD) is a non-neurotoxic, phytocannabinoid from cannabis with reported medicinal properties, including antiepileptic and anti-inflammatory activity. Several in vitro vivo studies have shown that CBD has antitumor potential against colorectal cancer (CRC), the third deadliest world. However, as different mutations influence effects can bind variety of receptors, it yet to be determined whether specific CRC affect CBD's efficacy treatment CRC. To investigate this, we selected four cell lines, HCT116, HT-29, LS174T, LS153, which harbor distinct mutations. Cells were treated range concentrations evaluate its cytotoxic impact on proliferation, migration, invasion by using live-cell imaging system. IC50 values then calculated for each parameter. The level endoplasmic reticulum (ER) stress pathway markers was also measured qRTPCR. requirements CB1 or CB2 receptor-medicated signaling investigated selective inhibitors AM251 SR144528, respectively. Our results demonstrate induces apoptosis halts lines concentration-dependent manner. showed potent tested no obvious effect such KRAS, BRAF, APC, PTEN, etc. induced ER cells but not healthy intestinal organoids. Cotreatment SR144528 inhibited indicating involvement receptor activation anticancer CBD. Together, these demonstrated could effective regardless underlying mutation through activation.
Language: Английский
Citations
0
SLAS DISCOVERY, Journal Year: 2025, Volume and Issue: unknown, P. 100213 - 100213
Published: Jan. 1, 2025
Brain metastasis (BM) from colon cancer is associated with a poor prognosis and restricted treatment alternatives, largely due to issues related blood-brain barrier (BBB) permeability the negative effects of standard chemotherapy. Nanotechnology improves efficacy by enabling targeted controlled drug delivery. This review article evaluates potential nanotechnology-based therapies for treating BM, emphasizing their capacity cross BBB, diminish metastatic growth, enhance overall survival rates. A multiple studies evaluated nanoparticles (NPs) as carriers chemotherapy, focusing on parameters including particle size, surface charge, drug-loading capacity. The study also reviewed that examined BBB penetration, in vitro tumor accumulation, vivo growth inhibition. In findings indicated NPs accumulate more efficiently BM tissue than healthy brain show significant penetration. vivo, nanotherapy markedly inhibited prolonged relative conventional chemotherapy or control treatments while exhibiting reduced side effects. Recent demonstrated plant extracts can effectively safely synthesize nanomaterials, positioning them viable environmentally friendly precursor nanomaterial production. Nanotechnology-based demonstrate minimizing systemic toxicity, enhancing therapeutic efficacy, facilitating Further research required confirm these implement clinical practice.
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106642 - 106642
Published: Jan. 1, 2025
Language: Английский
Citations
0
Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 136 - 136
Published: Jan. 30, 2025
(1) Background/Objectives: Primary and secondary brain tumours often hold devastating prognoses low survival rates despite the application of maximal neurosurgical resection, state-of-the-art radiotherapy chemotherapy. One limiting factor in their management is that several antineoplastic agents are unable to cross blood–brain barrier (BBB) reach tumour microenvironment. Nanomedicine could potential become an effective means drug delivery overcome previous hurdles towards neuro-oncological treatments. (2) Methods: A scoping review following PRISMA-ScR guidelines checklist was conducted using key terms input into PubMed find articles reflect emerging trends utilisation nanomedicine for primary tumours. (3) Results: The highlights various strategies by which different nanoparticles can be exploited bypass BBB; we provide a synthesis literature on ongoing contributions therapeutic protocols based chemotherapy, immunotherapy, focused ultrasound, radiotherapy/radiosurgery, radio-immunotherapy. (4) Conclusions: summarised this indicate encouraging advantageous properties as mechanisms; however, there still nanotoxicity issues largely remain addressed before translation these innovations from laboratory clinical practice.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1814 - 1814
Published: Feb. 20, 2025
Localization in the central nervous system, diffuse growth, presence of stem cells, and numerous resistance mechanisms, all make glioblastoma (GBM) an incurable tumor. The standard treatment GBM consisting surgery; radio- chemotherapy with temozolomide provides insufficient therapeutic benefit needs to be updated effective modern solutions. One most promising intensively explored approaches against is use nanotherapy. first, so far only, nanoparticle-based therapy approved for NanoThermTM. It based on iron oxide nanoparticles thermal ablation tumor a magnetic field. Numerous other types nanotherapies are being evaluated, including polymer lipid-based nanoformulations, nanodiscs, dendrimers, metallic, silica, or bioderived nanoparticles, among others. advantages these nanoscale drug carriers include improved penetration across blood-brain barrier, targeted delivery, biocompatibility, lower systemic toxicity, while major problems their implementation involve scaling up production high costs. Nevertheless, taking impressive benefits into consideration, it seems obvious that combined effort scientific world will need taken tackle challenges implement novel therapies clinics, giving hope battle can finally won.
Language: Английский
Citations
0
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 8, 2025
Glioblastoma (GBM) is a highly invasive malignancy with poor prognosis, primarily attributable to its diffuse infiltration into adjacent brain tissue, thereby complicating effective surgical resection. Current imaging modalities often struggle accurately identify tumor boundaries. Here, we general control non-repressed protein 5 (GCN5) as promising molecular target for GBM imaging, it expressed in lesions within and expression levels are significantly correlated grading. We develop dual-modal probe particle size of 20 nm, capable efficiently traversing the blood-brain barrier (BBB) GCN5 through adsorptive-mediated transcytosis (AMT). The employs dendrimers (Den) carriers, which loaded small molecule inhibitor specifically designed GCN5. This enhances preoperative delineation boundaries using magnetic resonance (MRI) facilitates intraoperative fluorescence image-guided procedures. Our work introduces tool boundary delineation, offering new opportunities precise resection GBM. development agents clearly defining margins essential navigation. Here this group identifies therefore designs dual mode nanoprobe BBB crossing vivo visualization typical
Language: Английский
Citations
0