Drug Delivery and Translational Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 19, 2024
Human
cells,
such
as
fibroblasts
and
particularly
human
mesenchymal
stem
cells
(hMSCs),
represent
a
promising
effective
therapeutic
tool
for
range
of
cell-based
therapies
used
to
treat
various
diseases.
The
delivery
remains
challenge
due
limitations
in
targeting,
invasiveness,
cell
viability.
To
address
these
challenges,
we
developed
microneedle
(MN)
system
minimally
invasive
with
high
cellular
stability.
MN
comprises
core
gelatin
methacryloyl
(GelMA)
hydrogel
embedded
fibroblasts,
encased
polylactic-co-glycolic
acid
(PLGA)
shell
that
enhances
structural
integrity
efficient
skin
penetration.
fabrication
process
involves
UV-crosslinking
the
GelMA
optimizing
both
encapsulation
strength.
This
achieves
over
80%
viability
after
seven
days
vitro,
conventional
formulation
providing
superior
stability
outcomes.
platform's
ability
ensure
sustained
presents
implications
future
applications
regenerative
medicine,
wound
healing,
localized
treatments
conditions.
opens
new
avenues
therapies,
offering
versatile
scalable
solution
delivery.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(3), P. 326 - 326
Published: Feb. 26, 2024
Microneedles
(MNs),
renowned
for
their
painless
and
minimally
invasive
qualities,
exhibit
significant
potential
facilitating
effective
drug
delivery,
vaccination,
targeted
sample
extraction.
Extracellular
vesicles
(EVs),
serving
as
cargo
MNs,
are
naturally
occurring
nanovesicles
secreted
by
cells
characterized
novel
biomarkers,
low
immunogenicity,
cell-source-specific
traits.
MNs
prove
instrumental
in
extracting
EVs
from
the
fluid,
thereby
a
promising
diagnostic
prognostic
tool.
To
harness
therapeutic
of
tissue
repair,
with
sustained
delivery
leverage
micron-sized
channels
to
enhance
site
concentration,
demonstrating
efficacy
treating
various
diseases,
such
Achillea
tendinopathy,
hair
loss,
spinal
cord
injury,
diabetic
ulcers.
EV-loaded
emerge
platform
repair
applications
skin,
cardiac,
tendon,
hair,
tissues.
This
review
commences
an
overview
subsequently
delving
into
role
MNs.
The
paper
then
synthesizes
latest
advancements
use
regenerative
extending
research
progress
disease
diagnosis
evaluations.
It
aims
offer
valuable
insights
forecast
future
trajectories
hope
inspiring
innovative
ideas
among
researchers
this
field.
Applied Mechanics,
Journal Year:
2024,
Volume and Issue:
5(2), P. 233 - 259
Published: March 22, 2024
A
variety
of
hollow
microneedle
(HMN)
designs
has
emerged
for
minimally
invasive
therapies
and
monitoring
systems.
In
this
study,
a
design
change
limiting
the
indentation
depth
(3D)
printed
custom
assembly
(circular
array
five
conical
frusta
with
without
stopper,
aspect
ratio
=
1.875)
fabricated
using
stereolithography
been
experimentally
validated
modeled
in
silico.
The
micro-indentation
profiles
generated
confined
compression
on
1
mm
±
0.073
alginate
films
enabled
generation
Prony
series,
where
displacement
ranged
from
100
to
250
µm.
These
constants
were
used
as
intrinsic
properties
simulating
experimental
ramp/release
profiles.
Puncture
occurred
two
distinct
hydrogel
formulations
at
150
µm
rate
0.1
mm/s
characterized
by
peak
force
3.5
N
(H
31
kPa)
8.3
36.5
kPa),
respectively.
Experimental
theoretical
alignments
trends
obtained
when
printing
resolution
was
simulated.
Higher
puncture
uniformity
inferred
stopper
confirmed
via
microscopy
profilometry.
Meanwhile,
poroviscoelasticity
characterization
is
required
distinguish
mass
loss
vs.
redistribution
post-indentation
through
pycnometry.
Results
paper
highlight
feasibility
insertion-depth
control
within
epidermis
thickness
first
time
solid
HMN
literature.
Journal of Thermoplastic Composite Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 9, 2024
Biomimetic
nanoparticles
(BioM
NPs)
are
an
innovative
strategy
for
nanomedicine
(NanoMed)
that
combines
the
advantages
of
artificial
materials
with
biological
functioning
natural
systems.
Ongoing
research
attempts
to
enhance
their
design,
and
stability,
solve
problems
broader
applications
in
medicine
biotechnology.
NanoMed
ideas
intensively
researched
preclinical
because
they
provide
unique
disease
management.
It
has
developed
novel
therapeutic
strategies
combating
viral
infections
increasing
treatment
success
rates.
The
creation
nanocarriers
drug
delivery
systems
is
critical
evolution
NanoMed,
but
there
still
much
learn
about
this
quickly
evolving
field.
To
contribute
existing
knowledge
cover
gaps,
our
present
review
article
will
discuss
state-of-the-art
BioM
NPs
three
sections.
First,
methods
NP
production
synergistic
interactions
human
cells,
tissues,
organs,
organ
be
discussed.
Followed
by
a
discussion
several
NanoMeds
(wound
healing,
targeted
delivery,
theranostics,
cancer
therapy,
bone
formation
and/or
regeneration),
concluding
application
NPs,
challenges
associated
these
applications,
prospects.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 8, 2024
Electrical
stimulation
has
been
hotpot
research
and
provoked
extensive
interest
in
a
broad
application
such
as
wound
closure,
tissue
injury
repair,
nerve
engineering.
In
particular,
immense
efforts
have
dedicated
to
developing
electrical
microneedles,
which
demonstrate
unique
features
terms
of
controllable
drug
release,
real-time
monitoring,
therapy,
thus
greatly
accelerating
the
process
healing.
Here,
review
state-of-art
concerning
microneedles
applied
for
treatment
is
presented.
After
comprehensive
analysis
mechanisms
on
healing,
derived
three
types
are
clarified
summarized.
Further,
their
applications
healing
highlighted.
Finally,
current
perspectives
directions
development
future
improving
addressed.
Drug Delivery and Translational Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 19, 2024
Human
cells,
such
as
fibroblasts
and
particularly
human
mesenchymal
stem
cells
(hMSCs),
represent
a
promising
effective
therapeutic
tool
for
range
of
cell-based
therapies
used
to
treat
various
diseases.
The
delivery
remains
challenge
due
limitations
in
targeting,
invasiveness,
cell
viability.
To
address
these
challenges,
we
developed
microneedle
(MN)
system
minimally
invasive
with
high
cellular
stability.
MN
comprises
core
gelatin
methacryloyl
(GelMA)
hydrogel
embedded
fibroblasts,
encased
polylactic-co-glycolic
acid
(PLGA)
shell
that
enhances
structural
integrity
efficient
skin
penetration.
fabrication
process
involves
UV-crosslinking
the
GelMA
optimizing
both
encapsulation
strength.
This
achieves
over
80%
viability
after
seven
days
vitro,
conventional
formulation
providing
superior
stability
outcomes.
platform's
ability
ensure
sustained
presents
implications
future
applications
regenerative
medicine,
wound
healing,
localized
treatments
conditions.
opens
new
avenues
therapies,
offering
versatile
scalable
solution
delivery.
