Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
38(6)
Published: March 26, 2024
Ferroptosis
is
a
new
form
of
cell
death
that
relies
on
iron
and
involves
an
imbalance
intracellular
reactive
oxygen
species
(ROS),
which
expected
to
help
alleviate
bottlenecks
in
tumor
treatment.
Herein,
sorafenib‐loaded
folic
acid‐armored
iron‐based
nMOF
was
designed
for
synergistic
inducing
ferroptosis
tumors.
The
particle
size
the
synthesized
SM@F
about
210nm,
drug
loading
rate
24.74%.
can
be
degraded
releases
sorafenib
ions
slowly,
resulting
release
overload
after
being
highly
uptaken
by
SMMC‐7721
cells.
effectively
inhibit
proliferation
cells,
this
effect
significantly
attenuated
inhibitors.
Mechanistic
investigations
revealed
could
increase
content
ROS,
lipid
peroxides;
decrease
glutathione
(GSH);
down‐regulate
GXP4
expression
results
indicate
cells
with
ferroptosis.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 5, 2025
Copper-based
nanoparticles
have
garnered
significant
interest
in
cancer
therapy
due
to
their
ability
induce
oxidative
stress
and
cuproptosis
cells.
However,
antitumor
effectiveness
is
constrained
by
the
dynamic
redox
balance
metabolic
shift
between
phosphorylation
glycolysis.
Here,
a
polydopamine-coated
copper-α-ketoglutaric
acid
(α-KG)
coordination
polymer
nanoparticle
(CKPP)
designed
for
combined
pyroptosis-cuproptosis
immunotherapy
amplifying
reactive
oxygen
species
(ROS)
production
regulating
cellular
metabolism.
The
intracellular
imbalance
achieved
through
synergistic
effects
of
α-KG-induced
mitochondrial
reprogramming,
photothermally
enhanced
superoxide
dismutase-like
activity
polydopamine,
glutathione
depletion
copper
ions.
multifaceted
modulation
results
substantial
increase
ROS
levels,
triggering
subsequent
pyroptosis
Furthermore,
α-KG
shifts
metabolism
from
glycolysis
phosphorylation,
thereby
enhancing
induced
combination
dyshomeostasis
inhibition
potent
enhancement
pyroptosis-cuproptosis-mediated
therapy.
In
murine
model
colorectal
cancer,
CKPP
exhibited
remarkable
anticancer
effect,
achieving
tumor
rate
96.3%
complete
eradication
two
out
five
cases.
Overall,
this
bio-engineered
metal-organic
nanocomposite
demonstrates
potential
treating
immunotherapy.
