Antioxidants,
Journal Year:
2024,
Volume and Issue:
14(1), P. 17 - 17
Published: Dec. 26, 2024
Spinal
cord
injury
(SCI)
initiates
a
cascade
of
secondary
damage
driven
by
oxidative
stress,
characterized
the
excessive
production
reactive
oxygen
species
and
other
molecules,
which
exacerbate
cellular
tissue
through
activation
deleterious
signaling
pathways.
This
review
provides
comprehensive
critical
evaluation
recent
advancements
in
antioxidant-based
therapeutic
strategies
for
SCI,
including
natural
compounds,
RNA-based
therapies,
stem
cell
interventions,
biomaterial
applications.
It
emphasizes
limitations
single-regimen
approaches,
particularly
their
limited
efficacy
suboptimal
delivery
to
injured
spinal
tissue,
while
highlighting
synergistic
potential
combination
therapies
that
integrate
multiple
modalities
address
multifaceted
pathophysiology
SCI.
By
analyzing
emerging
trends
current
limitations,
this
identifies
key
challenges
proposes
future
directions,
refinement
antioxidant
systems,
development
multi-targeted
overcome
structural
complexities
cord.
work
underscores
pressing
need
innovative
integrative
approaches
advance
clinical
translation
interventions
improve
outcomes
SCI
patients.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4198 - 4217
Published: Jan. 1, 2024
The
utilization
of
extracellular
vesicles
(EVs)
in
wound
healing
has
been
well-documented.However,
the
direct
administration
free
EVs
via
subcutaneous
injection
at
sites
may
result
rapid
dissipation
bioactive
components
and
diminished
therapeutic
efficacy.Functionalized
hydrogels
provide
effective
protection,
as
well
ensure
sustained
release
bioactivity
during
process,
making
them
an
ideal
candidate
material
for
delivering
EVs.In
this
review,
we
introduce
mechanisms
by
which
accelerate
healing,
then
elaborate
on
construction
strategies
engineered
EVs.Subsequently,
discuss
synthesis
application
delivery
systems
to
enhance
complicated
healing.Furthermore,
face
wounds,
functionalized
with
specific
microenvironment
regulation
capabilities,
such
antimicrobial,
anti-inflammatory,
immune
regulation,
used
loading
EVs,
potential
approaches
addressing
these
challenges.Ultimately,
deliberate
future
trajectories
outlooks,
offering
a
fresh
viewpoint
advancement
artificial
intelligence
(AI)-energized
materials
3D
bio-printed
multifunctional
hydrogel-based
dressings
biomedical
applications.
Neural Regeneration Research,
Journal Year:
2025,
Volume and Issue:
20(12), P. 3476 - 3500
Published: Jan. 13, 2025
Enhancing
neurological
recovery
and
improving
the
prognosis
of
spinal
cord
injury
have
gained
research
attention
recently.
Spinal
is
associated
with
a
complex
molecular
cellular
microenvironment.
This
complexity
has
prompted
researchers
to
elucidate
underlying
pathophysiological
mechanisms
changes
identify
effective
treatment
strategies.
Traditional
approaches
for
repair
include
surgery,
oral
or
intravenous
medications,
administration
neurotrophic
factors;
however,
efficacy
these
remains
inconclusive,
serious
adverse
reactions
continue
be
concern.
With
advancements
in
tissue
engineering
regenerative
medicine,
emerging
strategies
now
involve
nanoparticle-based
nanodelivery
systems,
scaffolds,
functional
techniques
that
incorporate
biomaterials,
bioengineering,
stem
cell,
growth
factors
as
well
three-dimensional
bioprinting.
Ideal
biomaterial
scaffolds
should
not
only
provide
structural
support
neuron
migration,
adhesion,
proliferation,
differentiation
but
also
mimic
mechanical
properties
natural
tissue.
Additionally,
facilitate
axon
neurogenesis
by
offering
adjustable
topography
range
physical
biochemical
cues.
The
three-dimensionally
interconnected
porous
structure
appropriate
physicochemical
enabled
biomimetic
printing
technology
can
maximize
potential
biomaterials
used
treating
injury.
Therefore,
correct
selection
application
coupled
successful
clinical
translation,
represent
promising
objectives
enhance
review
elucidates
key
occurrence
regeneration
post-injury,
including
neuroinflammation,
oxidative
stress,
regeneration,
angiogenesis.
briefly
discusses
critical
role
systems
injured
cord,
highlighting
influence
nanoparticles
affect
delivery
efficiency.
Finally,
this
highlights
It
various
types
their
integrations
cells
factors,
optimization
scaffold
design.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101556 - 101556
Published: Feb. 4, 2025
Spinal
cord
injury
(SCI)
presents
a
formidable
challenge
in
clinical
settings,
resulting
sensory
and
motor
function
loss
imposing
significant
personal
societal
burdens.
However,
owning
to
the
adverse
microenvironment
limited
regenerative
capacity,
achieving
complete
functional
recovery
after
SCI
remains
elusive.
Additionally,
traditional
interventions
including
surgery
medication
have
series
of
limitations
that
restrict
effectiveness
treatment.
Recently,
tissue
engineering
(TE)
has
emerged
as
promising
approach
for
promoting
neural
regeneration
SCI,
which
can
effectively
delivery
drugs
into
site
cells
improve
survival
differential.
Here,
we
outline
main
pathophysiology
events
post
injury,
further
discuss
materials
common
assembly
strategies
used
scaffolds
treatment,
expound
on
latest
advancements
treatment
methods
based
drug
cell
detail,
propose
future
directions
repair
with
TE
highlight
potential
applications.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101585 - 101585
Published: Feb. 18, 2025
Diabetic
wounds
often
exhibit
delayed
healing
due
to
compromised
vascular
function
and
intensified
inflammation.
In
this
study,
we
overexpressed
Thymosin
β4
(Tβ4)
in
Adipose-Derived
Stem
Cells
(ADSCs)
produce
Exosomes
(Exos)
rich
Tβ4.
We
then
utilized
a
dual
photopolymerizable
hydrogel
composed
of
Hyaluronic
Acid
Methacryloyl
(HAMA)
Poly-L-lysine
(PLMA)
for
the
sustained
release
Tβ4-Exos
on
diabetic
wounds.
The
results
showed
that
could
stimulate
angiogenesis
collagen
synthesis,
mitigate
inflammation
by
promoting
polarization
M1-type
macrophages
inhibiting
M2-type
macrophages.
Furthermore,
was
found
activate
PI3K/AKT/mTOR/HIF-1a
signaling
pathway,
thereby
enhancing
proliferation.
summary,
HAMA-PLMA
(HP)
management
through
upregulation
HIF-1a
pathway
modulation
macrophage
proliferation
significantly
accelerated
process
