Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106312 - 106312
Published: Oct. 1, 2024
Language: Английский
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Jan. 20, 2025
Language: Английский
Citations
4
Science Advances, Journal Year: 2025, Volume and Issue: 11(9)
Published: Feb. 26, 2025
Naturally occurring extracellular vesicles (EVs) and synthetic nanoparticles like liposomes have revolutionized precision diagnostics medicine. EVs excel in biocompatibility cell targeting, while offer enhanced drug loading capacity scalability. The clinical translation of is hindered by challenges including low yield heterogeneity, whereas face rapid immune clearance limited targeting efficiency. To bridge these gaps, biomimetic (SVs) emerged as innovative platforms, combining the advantageous properties liposomes. This review emphasizes critical aspects EV biology, such mechanisms EV-cell interaction source-dependent functionalities modulation, tissue regeneration, informing SV engineering. We reviewed a broad array SVs, with focus on lipid bilayered functionalized proteins. These include cell-derived nanovesicles, protein-functionalized liposomes, hybrid vesicles. By addressing current highlighting opportunities, this aims to advance SVs for transformative biomedical applications.
Language: Английский
Citations
2
ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16359 - 16394
Published: June 11, 2024
Glioblastoma (GBM) remains the epitome of aggressiveness and lethality in spectrum brain tumors, primarily due to blood–brain barrier (BBB) that hinders effective treatment delivery, tumor heterogeneity, presence treatment-resistant stem cells contribute recurrence. Nanoparticles (NPs) have been used overcome these obstacles by attaching targeting ligands enhance therapeutic efficacy. Among ligands, peptides stand out their ease synthesis high selectivity. This article aims review single multiligand strategies critically. In addition, it highlights other integrate effects external stimuli, biomimetic approaches, chemical approaches as nanocatalytic medicine, revealing significant potential treating GBM with peptide-functionalized NPs. Alternative routes parenteral administration, specifically nose-to-brain delivery local within resected cavity, are also discussed. Finally, an overview them discussed provide a perspective on this promising field therapy.
Language: Английский
Citations
12
Cancers, Journal Year: 2024, Volume and Issue: 16(4), P. 823 - 823
Published: Feb. 18, 2024
Gliomas, the most prevalent primary malignant brain tumors, present a challenging prognosis even after undergoing surgery, radiation, and chemotherapy. Exosomes, nano-sized extracellular vesicles secreted by various cells, play pivotal role in glioma progression contribute to resistance against chemotherapy radiotherapy facilitating transportation of biological molecules promoting intercellular communication within tumor microenvironment. Moreover, exosomes exhibit remarkable ability traverse blood–brain barrier, positioning them as potent carriers for therapeutic delivery. These attributes hold promise enhancing diagnosis, prognosis, treatment. Recent years have witnessed significant advancements exosome research realm tumors. In this article, we primarily focus on elucidating development, highlighting latest breakthroughs diagnostic approaches, outlining prospective directions future research.
Language: Английский
Citations
10
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(7), P. 639 - 639
Published: April 6, 2024
Exosomes are spherical extracellular nanovesicles with an endosomal origin and unilamellar lipid-bilayer structure sizes ranging from 30 to 100 nm. They contain a large range of proteins, lipids, nucleic acid species, depending on the state vesicle (EV)-secreting cell. EVs’ function is encapsulate part EV-producing cell content, transport it through biological fluids targeted recipient, deliver their cargos specifically within aimed recipient cells. Therefore, exosomes considered be potential drug-delivery systems that can stably cargo into Various cell-derived produced for medical issues, but use therapeutic purposes still faces several problems. Some these difficulties avoided by resorting hemisynthetic approaches. We highlight here uses alternative exosome-mimes involving cell-membrane coatings artificial nanocarriers or hybridization between liposomes. also detail drug-loading strategies deployed make them drug-carrier summarize ongoing clinical trials exosome-like structures. Finally, we open questions before considering disposals confident delivery.
Language: Английский
Citations
9
Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101694 - 101694
Published: March 1, 2025
Language: Английский
Citations
1
Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107308 - 107308
Published: July 15, 2024
Glioma is the most common intracranial malignant tumor, with severe difficulty in treatment and a low patient survival rate. Due to heterogeneity invasiveness of tumors, lack personalized clinical design, physiological barriers, it often difficult accurately distinguish gliomas, which dramatically affects subsequent diagnosis, imaging treatment, prognosis. Fortunately, nano-delivery systems have demonstrated unprecedented capabilities diagnosing treating gliomas recent years. They been modified surface efficiently traverse BBB/BBTB, target lesion sites, intelligently release therapeutic or contrast agents, thereby achieving precise treatment. In this review, we focus on systems. Firstly, provide an overview standard emerging diagnostic technologies for glioma practice. After induction analysis, summarizing delivery methods drug systems, design nanoparticles, their new advances Finally, discussed prospects potential challenges drug-delivery glioma.
Language: Английский
Citations
8
European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 203, P. 114460 - 114460
Published: Aug. 31, 2024
Glioblastoma (GBM) stands for the most common and aggressive type of brain tumour in adults. It is highly invasive, which explains its short rate survival. Little known about risk factors, current therapy still ineffective. Hence, efforts are underway to develop novel effective treatment approaches against this cancer. Exosomes being explored as a promising strategy conveying delivering therapeutic cargo GBM cells. They can fuse with cell membrane and, consequently, serve delivery systems context. Due their nanoscale size, exosomes cross blood-brain barrier (BBB), constitutes significant hurdle chemotherapeutic drugs used GBM. subsequently inhibit oncogenes, activate suppressor genes, induce immune responses, control growth. However, despite representing tool GBM, further research clinical studies regarding exosome biology, engineering, applications need be completed. Here, we sought review application through an in-depth analysis scientific on entire process, from isolation purification design transformation into anti-oncogenic drug systems. Surface modification enhance BBB penetration GBM-cell targeting also topic discussion.
Language: Английский
Citations
7
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 239, P. 113938 - 113938
Published: May 3, 2024
Language: Английский
Citations
5
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114500 - 114500
Published: Jan. 6, 2025
Language: Английский
Citations
0