Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
Abstract
Extracellular
vesicles
(EVs)
have
emerged
as
promising
bioactive
carriers
for
delivering
therapeutic
agents,
including
nucleic
acids,
proteins,
and
small‐molecule
drugs,
owing
to
their
excellent
physicochemical
stability
biocompatibility.
However,
comprehensive
reviews
on
the
various
types
of
EV‐based
nanomedicines
cancer
therapy
remain
scarce.
This
review
explores
potential
EVs
antitumor
nanomedicines.
Methods
EV
extraction,
drug
loading,
engineering
modifications
are
systematically
examined,
strengths
limitations
these
technical
approaches
critically
assessed.
Additionally,
key
strategies
developing
therapies
highlighted.
Finally,
opportunities
challenges
associated
with
advancing
toward
clinical
translation
discussed.
With
integration
multiple
disciplines,
robust
platforms
expected
be
manufactured
provide
more
personalized
effective
solutions
oncology
patients.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
38, P. 55 - 72
Published: April 23, 2024
As
a
natural
immune
cell
and
antigen
presenting
cell,
macrophages
have
been
studied
engineered
to
treat
human
diseases.
Macrophages
are
well-suited
for
use
as
drug
carriers
because
of
their
biological
characteristics,
such
excellent
biocompatibility,
long
circulation,
intrinsic
inflammatory
homing
phagocytosis.
Meanwhile,
macrophages'
uniquely
high
plasticity
easy
re-education
polarization
facilitates
part
efficacious
therapeutics
the
treatment
diseases
or
tumors.
Although
recent
studies
demonstrated
promising
advances
in
macrophage-based
delivery,
several
challenges
currently
hinder
further
improvement
therapeutic
effect
clinical
application.
This
article
focuses
on
main
utilizing
from
selection
macrophage
sources,
loading,
maintenance
phenotypes,
migration
release
at
target
sites.
In
addition,
corresponding
strategies
insights
related
these
described.
Finally,
we
also
provide
perspective
shortcomings
road
translation
production.
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: March 7, 2025
Abstract
Macrophages
are
immune
cells
belonging
to
the
mononuclear
phagocyte
system.
They
play
crucial
roles
in
defense,
surveillance,
and
homeostasis.
This
review
systematically
discusses
types
of
hematopoietic
progenitors
that
give
rise
macrophages,
including
primitive
progenitors,
erythro-myeloid
stem
cells.
These
have
distinct
genetic
backgrounds
developmental
processes.
Accordingly,
macrophages
exhibit
complex
diverse
functions
body,
phagocytosis
clearance
cellular
debris,
antigen
presentation,
response,
regulation
inflammation
cytokine
production,
tissue
remodeling
repair,
multi-level
regulatory
signaling
pathways/crosstalk
involved
homeostasis
physiology.
Besides,
tumor-associated
a
key
component
TME,
exhibiting
both
anti-tumor
pro-tumor
properties.
Furthermore,
functional
status
is
closely
linked
development
various
diseases,
cancer,
autoimmune
disorders,
cardiovascular
disease,
neurodegenerative
metabolic
conditions,
trauma.
Targeting
has
emerged
as
promising
therapeutic
strategy
these
contexts.
Clinical
trials
macrophage-based
targeted
drugs,
immunotherapies,
nanoparticle-based
therapy
were
comprehensively
summarized.
Potential
challenges
future
directions
targeting
also
been
discussed.
Overall,
our
highlights
significance
this
versatile
cell
human
health
which
expected
inform
research
clinical
practice.
Clinical and Translational Medicine,
Journal Year:
2024,
Volume and Issue:
14(4)
Published: April 1, 2024
Breast
cancer
remains
a
global
health
challenge,
necessitating
innovative
therapeutic
approaches.
Immunomodulation
and
immunotherapy
have
emerged
as
promising
strategies
for
breast
treatment.
Engineered
exosomes
are
the
sort
of
modified
with
surface
decoration
internal
molecules.
Through
suitable
modifications,
engineered
exhibit
capability
to
overcome
limitations
associated
traditional
This
ability
opens
up
novel
avenues
development
more
effective,
personalized,
minimally
invasive
interventions.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(9), P. 3834 - 3854
Published: June 3, 2024
Immunotherapy
is
an
important
cancer
treatment
method
that
offers
hope
for
curing
patients.
While
immunotherapy
has
achieved
initial
success,
a
major
obstacle
to
its
widespread
adoption
the
inability
benefit
majority
of
The
success
or
failure
closely
linked
tumor's
immune
microenvironment.
Recently,
there
been
significant
attention
on
strategies
regulate
tumor
microenvironment
in
order
stimulate
anti-tumor
responses
immunotherapy.
distinctive
physical
properties
and
design
flexibility
nanomedicines
have
extensively
utilized
target
cells
(including
tumor-associated
macrophages
(TAMs),
T
cells,
myeloid-derived
suppressor
(MDSCs),
fibroblasts
(TAFs)),
offering
promising
advancements
In
this
article,
we
reviewed
aimed
at
targeting
various
focus
models
are
based
nanomedicines,
with
goal
inducing
enhancing
improve
It
worth
noting
combining
other
treatments,
such
as
chemotherapy,
radiotherapy,
photodynamic
therapy,
can
maximize
therapeutic
effects.
Finally,
identified
challenges
nanotechnology-mediated
needs
overcome
more
effective
nanosystems.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 7, 2024
Chemotherapy
is
currently
a
widely
used
treatment
for
cancer
in
clinical
settings.
Some
chemotherapeutic
drugs
such
as
oxaliplatin
(OXA)
can
cause
tumor
immunogenic
cell
death
(ICD),
activate
immunity,
and
realize
chemoimmunotherapy
tumors.
However,
the
low
degree
of
accumulation
immunosuppressive
microenvironment
tumors
limit
immunotherapeutic
efficacy
these
drugs.
T
immunoreceptor
with
Ig
ITIM
domains
(TIGIT)/poliovirus
receptor
(PVR)
an
inhibitory
immune
checkpoint
pathway
involved
mediating
natural
killer
(NK)
exhaustion
TIGIT
expression
up-regulated
NK
cells
CD8
Biological
carriers
have
emerged
as
significant
tools
to
deliver
radionuclides
in
nuclear
medicine,
providing
a
meaningful
perspective
for
tumor
imaging
and
treatment.
Various
radionuclide-labeled
biological
been
developed
meet
the
needs
of
biomedical
applications.
This
review
introduces
principles
radionuclide-mediated
therapy
selected
criteria
them,
well
comprehensive
description
characteristics
functions
representative
including
bacteria,
cells,
viruses,
their
derivatives,
emphasizing
labeled
strategies
combined
with
radionuclides.
Subsequently,
we
in-depth
introduce
application
treatment,
behaviors
vivo
metastasis
treatment
by
radionuclide
therapy,
plus
other
radiation-induced
photodynamic
therapy.
Finally,
challenges
prospects
are
discussed
improve
shortcomings
this
innovative
platform
promote
clinical
transformation
field
medical
imaging.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Extracellular
vesicles
(EVs)
are
cell
derived
nanovesicles
which
implicated
in
both
physiological
and
pathological
intercellular
communication,
including
the
initiation,
progression,
metastasis
of
cancer.
The
exchange
biomolecules
between
stromal
cells
cancer
via
EVs
can
provide
a
window
to
monitor
development
real
time
for
better
diagnostic
interventional
strategies.
In
addition,
process
secretion
internalization
by
tumor
microenvironment
(TME)
be
exploited
delivering
therapeutics.
have
potential
targeted,
biocompatible,
efficient
delivery
platform
treatment
other
diseases.
Natural
as
well
engineered
nanomedicine
immense
disease
intervention.
Here,
we
an
overview
current
knowledge
EVs'
function
therapeutic
applications
setting,
EV
engineering
