Bio-Medical Materials and Engineering,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 13, 2024
Background
Mesenchymal
stem
cells-derived
exosomes,
crucial
in
regenerative
medicine,
have
been
explored
for
their
potential
the
functional
modification
of
bone
scaffolds.
Objective
To
design
a
functionally
modified
biomimetic
nanohydroxyapatite
using
exosomes
and
explore
its
effects
on
regeneration.
Methods
A
(named
as
tHA)
was
fabricated
previous
methods
polydopamine
(pDA)
structure
template,
(Exo)
derived
from
periodontal
ligament
cells
(PDLSCs)
were
used
to
modify
tHA
scaffold
material
through
pDA.
The
composite
(tHA-Exo)
proliferation
osteogenic
differentiation
investigated.
Furthermore,
effect
regeneration
also
evaluated
vivo.
Results
Exosomes
can
be
loaded
onto
via
pDA
tHA-Exo
releases
sustained
stable
manner.
showed
improved
cytocompatibility
compared
controls.
Additionally,
significantly
enhanced
PDLSCs.
More
importantly,
animal
experiments
shown
that
could
dramatically
promote
Conclusion
nanoparticles,
by
PDLSCs-Exo
pDA,
promoted
improving
potential,
which
serve
promising
promoting
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 12, 2024
Idiopathic
pulmonary
fibrosis
(IPF)
is
exacerbated
by
injurious
mechanical
forces
that
destabilize
the
microenvironment
homeostasis,
leading
to
alveolar
dysfunction
and
exacerbating
disease
severity.
However,
given
inherent
mechanosensitivity
of
fibrotic
lungs,
where
type
II
epithelial
cells
(AEC
IIs)
are
subjected
persistent
stretching
overactivated
myofibroblasts
experience
malignant
interactions
during
mechanotransduction,
it
becomes
imperative
develop
effective
strategies
modulate
microenvironment.
Herein,
cyclo
(RGDfC)
peptide-decorated
zeolitic
imidazolate
framework-8
nanoparticles
(named
ZDFPR
NPs)
constructed
target
repair
aberrant
force
levels
in
pathological
lungs.
Specifically,
reduces
tension
AEC
IIs
pH-responsive
NPs
release
zinc
ions
7,
8-dihydroxyflavone
promote
differentiation.
Meanwhile,
between
myofibroblast
contractility
extracellular
matrix
stiffness
mechanotransduction
disrupted
fasudil
inhibition
ROCK
signaling
pathway.
The
results
show
successfully
restored
homeostasis
terminated
process
bleomycin-induced
mice.
This
study
not
only
presents
a
promising
strategy
for
modulating
but
also
pioneers
novel
avenue
IPF
treatment.
Drug Delivery,
Journal Year:
2024,
Volume and Issue:
31(1)
Published: Nov. 8, 2024
The
advancement
of
drug
delivery
systems
(DDSs)
in
recent
decades
has
demonstrated
significant
potential
enhancing
the
efficacy
pharmacological
agents.
Despite
approval
certain
DDSs
for
clinical
use,
challenges
such
as
rapid
clearance
from
circulation,
toxic
accumulation
body,
and
ineffective
targeted
persist
obstacles
to
successful
application.
Blood
cell-based
have
emerged
a
popular
strategy
administration,
offering
enhanced
biocompatibility,
stability,
prolonged
circulation.
These
are
well-suited
systemic
played
crucial
role
formulating
optimal
combinations
treating
variety
diseases
both
preclinical
studies
trials.
This
review
focuses
on
advancements
applications
utilizing
blood
cells
their
membrane-derived
microvesicles.
It
addresses
current
therapeutic
at
organ
tissue
levels,
highlighting
deployment
cellular
level.
Furthermore,
it
explores
mechanisms
uptake
vectors
subcellular
Additionally,
discusses
opportunities
associated
with
these
DDSs.
Scientific African,
Journal Year:
2024,
Volume and Issue:
25, P. e02274 - e02274
Published: June 5, 2024
Alzheimer's
disease
(AZD)
has
emerged
as
a
catastrophic
world
health
concern
in
tandem
with
the
phenomenon
of
worldwide
aging.
The
purpose
this
study
was
to
examine
curative
effects
bone
marrow
stem
cell-derived
exosomes
(BMSCDEXO)
overcome
sodium
azide
(NaN3)-induced
AZD
rat
model.
animals
were
classified
into
two
main
groups:
first
group
(8
rats)
kept
control;
second
(24
received
intraperitoneal
treatment
NaN3
(12.5
mg/kg
for
five
days
and
10
next
nine
days).
Morris
Water
Maze
(MWM)
Y
maze
tests
carried
out
evaluate
induction.
Then,
three
equal
subgroups
follows:
group,
AZD+
donepezil
(DNP)
which
orally
5
DNP
daily
four
weeks,
BMSCDEXO
injected
single
dose
(intravenously,
100
µL).
results
indicated
that
attenuated
behavioral
signs
MWM
correlated
improvements
amyloid-beta
precursor
protein
(AβPP),
amyloid
beta
(Aβ)
accumulation,
tau
phosphorylation
through
mechanisms
involved
prevention
stress-related
biochemical
redox.
Furthermore,
it
enhances
levels
antioxidant
activities,
mitochondrial
functions,
cytochrome
c
oxidase
(COX-IV).
Finally,
we
conclude
modulates
cognitive
impairment
inhibition
amyloidogenesis
mitoprotection
NaN3-induced
comparison
therapeutic
drug
donepezil.
International Journal of Science and Research (IJSR),
Journal Year:
2024,
Volume and Issue:
13(6), P. 235 - 243
Published: June 5, 2024
Wounds
occur
when
the
skin
is
harmed
and
its
protective
barrier
compromised.
Over
time,
number
of
acute
wounds
caused
by
physical
injuries
has
decreased
due
to
changes
in
types
illnesses
people
experience.
Meanwhile,
there
been
an
increase
prevalence
chronic
among
individuals
factors
such
as
aging,
diabetes,
infection.
There
are
currently
over
six
million
United
States
who
dealing
with
wounds.
These
collectively
lead
annual
expenses
ten
billion
dollars.
Treating
can
be
quite
challenging
various
factors.
Traditional
treatments
for
include
dermatological
procedures
like
grafting,
flap
transplantation,
negative-pressure
wound
therapy,
gauze
dressing.
On
other
hand,
these
potentially
harm
tissues
or
limit
activities.
In
field
biomedicine,
nanobiotechnology
now
being
utilized.
This
encompasses
diverse
technologies
derived
from
engineering,
chemistry,
biology.
article
aims
explore
development,
execution,
testing
nanotechnology-based
healing
a
way
that
accessible
relatable
readers.
We
also
highlight
potential
therapeutic
applications
nanomedicine
treating
specific
conditions.
this
study,
we
present
concise
overview
previous
research,
laying
foundation
future
advancements
care
using
multifunctional
smart
system
based
on
nanotechnology
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
2, P. 100016 - 100016
Published: March 1, 2024
Liver
damage
resulting
from
the
administration
of
various
allopathic
drugs
and
their
associated
toxicity
has
become
a
major
health
problem,
leading
to
hepatic
fibrosis,
cirrhosis,
metabolic
disorders.
This
epidemic
condition
liver
disease
represents
global
cause
death
morbidity.
Although
orthotopic
transplantation
remains
vital
treatment
option
for
fibrotic
conditions,
its
efficacy
is
limited
by
organ
scarcity
risk
immunological
rejection.
Consequently,
alternative
therapeutic
approaches
are
urgently
needed.
Cell-based
therapy
utilizing
mesenchymal
stem
cells
(MSCs)
garnered
considerable
interest
as
promising
modality.
MSCs
exhibit
immunomodulatory
properties
can
differentiate
into
hepatocytes,
thus
facilitating
regeneration
damaged
hepatocytes
increasing
residual
hepatocyte
proliferation
while
inhibiting
activation
or
apoptosis
stellate
cells.
However,
despite
potential
benefits,
transplanted
often
low
survival
rates
due
inadequate
oxidative
inflammatory
stress
resistance.
Plants
harbor
diverse
array
bioactive
compounds
known
possess
hepatoprotective
antioxidant
properties.
Nanomaterials
play
crucial
role
in
regenerative
medicine
providing
targeted
delivery
agents
scaffolds
tissue
engineering.
In
treating
liver,
nanomaterials
help
mitigate
fibrosis
progression
promote
through
controlled
release
anti-fibrotic
growth
factors.
review
highlights
synergistic
cell-based
therapy,
natural
antioxidants,
differentiation
factors,
nanotechnology
combating
advancing
medicine.
These
combined
offer
avenues
effectively
conditions
promoting
regeneration.
Bio-Medical Materials and Engineering,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 13, 2024
Background
Mesenchymal
stem
cells-derived
exosomes,
crucial
in
regenerative
medicine,
have
been
explored
for
their
potential
the
functional
modification
of
bone
scaffolds.
Objective
To
design
a
functionally
modified
biomimetic
nanohydroxyapatite
using
exosomes
and
explore
its
effects
on
regeneration.
Methods
A
(named
as
tHA)
was
fabricated
previous
methods
polydopamine
(pDA)
structure
template,
(Exo)
derived
from
periodontal
ligament
cells
(PDLSCs)
were
used
to
modify
tHA
scaffold
material
through
pDA.
The
composite
(tHA-Exo)
proliferation
osteogenic
differentiation
investigated.
Furthermore,
effect
regeneration
also
evaluated
vivo.
Results
Exosomes
can
be
loaded
onto
via
pDA
tHA-Exo
releases
sustained
stable
manner.
showed
improved
cytocompatibility
compared
controls.
Additionally,
significantly
enhanced
PDLSCs.
More
importantly,
animal
experiments
shown
that
could
dramatically
promote
Conclusion
nanoparticles,
by
PDLSCs-Exo
pDA,
promoted
improving
potential,
which
serve
promising
promoting
