Peptide-Amphiphilic Nanoassemblies as a Responsive Senolytic Navigator for Targeted Removal of Senescent Cardiomyocytes to Ameliorate Heart Failure DOI
Zhiye Wu, Yinghua Zeng,

Hui-Ming Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Heart failure (HF) represents the terminal stage of numerous cardiovascular disorders and lacks effective therapeutic strategies. The accumulation senescent cardiomyocytes is a cardinal characteristic HF, contributing to myocardial dysfunction deteriorating microenvironment through development senescence-associated secretory phenotypes (SASPs), ultimately culminating in pathological remodeling. Senolytics, promising strategy that selectively induces apoptosis cells, faces challenges due nonspecific effects, raising concerns for clinical implementation. In this study, we developed peptide-amphiphilic nanoassemblies as responsive drug navigators targeted delivery. modular comprise hydrophilic domain containing CD9-binding peptide, hydrophobic incorporating reactive oxygen species (ROS)-responsive motif, an alkyl tail encapsulation senolytic ABT263. CD9-targeted ROS-responsive (AP@ABT263) specifically recognized modulated release ABT263 presence elevated intracellular ROS levels. AP@ABT263 treatment significantly enhanced delivery cells both vitro vivo while showing minimal toxicity normal other tissues. Our findings provide compelling evidence efficiently eradicated cardiomyocytes, cardiac function, attenuated deleterious effects SASP, thereby preventing adverse summary, highly approach controlled providing valuable insights into intelligent pharmaceutical interventions management HF.

Language: Английский

Flavonoids for gastrointestinal tract local and associated systemic effects: A review of clinical trials and future perspectives DOI Creative Commons
Xiaopeng Li, Enjun Xie,

Shumin Sun

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Flavonoids are naturally occurring dietary phytochemicals with significant antioxidant effects aside from several health benefits. People often consume them in combination other food components. Compiling data establishes a link between bioactive flavonoids and prevention of diseases animal models, including cardiovascular diseases, diabetes, gut dysbiosis, metabolic dysfunction-associated steatotic liver disease (MASLD). However, numerous clinical studies have demonstrated the ineffectiveness contradicting rodent thereby challenging validity using as supplements. This review provides perspective to emphasize effective roles well summarize their specific mechanisms animals briefly. First, this offers an in-depth elucidation processes within human, encompassing small, large intestine, liver. Furthermore, comprehensive overview various functions gastrointestinal tract, hindering breakdown assimilation macronutrients, such polysaccharides lipids, regulating hormone secretion inhibition mineral iron absorption. In unabsorbed major portion interact flora leading biotransformation. Once absorbed circulated bloodstream, or metabolites exert beneficial systemic effects. Lastly, we examine protective disorders, endothelial dysfunction, MASLD, disease, obesity, hyperlipidemia, insulin resistance. conclusion, outlines safety future prospects field health, especially syndrome (MetS).

Language: Английский

Citations

2
Ferroptosis: A novel therapeutic target of natural products against doxorubicin-induced cardiotoxicity DOI Open Access
Xiaojiao Yi, Qi Wang,

Mengjie Zhang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117217 - 117217

Published: July 29, 2024

Doxorubicin (DOX), a commonly used chemotherapy drug, is hindered due to its tendency induce cardiotoxicity (DIC). Ferroptosis, novel mode of programmed cell death, has received substantial attention for involvement in DIC. Recently, natural product-derived ferroptosis regulator emerged as potential strategy treating In this review, comprehensive search was conducted across PubMed, Web Science, Google Scholar, and ScienceDirect databases gather relevant articles on the use products DIC relation ferroptosis. The available papers were carefully reviewed summarize therapeutic effects underlying mechanisms modulating treatment. It found that plays an important role pathogenesis, with dysregulated expression ferroptosis-related proteins strongly implicated condition. Natural products, such flavonoids, polyphenols, terpenoids, quinones can act GPX4 activators, Nrf2 agonists, lipid peroxidation inhibitors, thereby enhancing viability, attenuating myocardial fibrosis, improving cardiac function, suppressing both vitro vivo models This review demonstrates strong correlation between DOX-induced key proteins, GPX4, Keap1, Nrf2, AMPK, HMOX1. are likely exert against by activity these proteins.

Language: Английский

Citations

6
Restoring bone-fat equilibrium: Baicalin's impact on P38 MAPK pathway for treating diabetic osteoporosis DOI Open Access

Weicheng Qin,

Qi Shang,

Gengyang Shen

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116571 - 116571

Published: April 26, 2024

Diabetes can lead to a disorder of bone-fat balance, significant cause osteoporosis due changes in environmental factors. Baicalin (Bai), an active ingredient Scutellaria baicalensis, has been confirmed possess antioxidant, hypoglycemic, and anti-osteoporotic effects. However, comprehensive understanding Bai's influence on diabetic (DOP), including its effects underlying mechanisms, remains elusive. This study investigated impact the equilibrium rats with DOP. The results indicated that Bai alleviated bone damage DOP by promoting osteogenesis inhibiting adipogenesis. Concurrently, through bioinformatics analysis, it was suggested mechanism action might involve P38-MAPK pathway. In vitro, found enhance development marrow mesenchymal stem cells (BMSCs) towards osteogenic lineages while suppressing their differentiation adipogenic lineages. It discovered promotion BMSC depends Additionally, synergistic effect mediated inhibitor suppressed differentiation. Our research indicates pathway play role osteogenic-adipogenic BMSCs, showcasing potential for treatment. highlights ability regulate between fat, presenting novel approach adressing

Language: Английский

Citations

5
Control the Gene Delivery and Anticancer Efficacy of Peptides through Chiral Modulation DOI
Zixuan Wang, Lei Yue,

Jiwei Min

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Incorporating d-amino acids into peptides can influence the intermolecular interactions of peptides, thus determining morphology and functionality self-assembled supramolecular structures. Based on this, we propose a modular chirality regulation strategy designed four chiral by adjusting different functional modules. The control coassembly nucleic virus-like vesicles with controlled diameters enzyme-responsiveness. Compared homochiral heterochiral inversion in their hydrophobic domain transformed more assemblies response to highly expressed enzyme matrix metalloproteinase 7 (MMP-7) cancer cells showed higher endosomal membrane disruption activity. Moreover, exhibit high efficiency selectivity delivering siRNA gene drugs inhibiting cell growth, achieving mortality rate 95% cells. These results provide promising for designing peptide-based acid delivery systems through modulation.

Language: Английский

Citations

0
Cancer-targeting drug conjugates drives a new era in precise cancer treatment DOI

Jia Deng,

Jianbin Shi, Dan Li

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110960 - 110960

Published: Feb. 1, 2025

Language: Английский

Citations

0
Iron homeostasis and ferroptosis in muscle diseases and disorders: mechanisms and therapeutic prospects DOI Creative Commons
Qin Ru, Yusheng Li, Feng Zhang

et al.

Bone Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 25, 2025

Abstract The muscular system plays a critical role in the human body by governing skeletal movement, cardiovascular function, and activities of digestive organs. Additionally, muscle tissues serve an endocrine function secreting myogenic cytokines, thereby regulating metabolism throughout entire body. Maintaining requires iron homeostasis. Recent studies suggest that disruptions ferroptosis, form iron-dependent cell death, are essential contributors to progression wide range diseases disorders, including sarcopenia, cardiomyopathy, amyotrophic lateral sclerosis. Thus, comprehensive overview mechanisms ferroptosis these conditions is crucial for identifying potential therapeutic targets developing new strategies disease treatment and/or prevention. This review aims summarize recent advances understanding molecular underlying context injury, as well associated disorders. Moreover, we discuss within pathway possible managing Finally, shed light on current limitations future prospects interventions targeting ferroptosis.

Language: Английский

Citations

0
Bimetallic NiCu‐MOF Protects DOX‐Induced Myocardial Injury and Cardiac Dysfunction by Suppressing Ferroptosis and Inflammation DOI Open Access
Lu Liu,

Daiyong Chao,

Qing Dong

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract Doxorubicin (DOX), a potent anthracycline chemotherapeutic agent, is widely used in cancer treatment but associated with significant adverse effects, particularly DOX‐induced cardiomyopathy (DIC). DIC pathogenesis involves the generation of reactive oxygen species (ROS) and ferroptosis induction. Novel therapeutic strategies targeting antioxidant defenses inhibition are essential for mitigating DIC. An innovative bimetallic metal‐organic framework (MOF), NiCu‐MOF (NCM), developed, exhibiting multifaceted enzyme‐mimicking activities that effectively scavenge broad spectrum ROS. Additionally, NCM exhibits excellent iron‐chelating ability. In vitro experiments demonstrate significantly reduces cardiomyocyte death by attenuating ROS levels inhibiting ferroptosis. Furthermore, mouse model DIC, results substantial myocardial protection, evidenced improved cardiac function structural integrity. This protective effect attributed to suppression ferroptosis, preservation mitochondrial function, attenuation inflammatory responses. Collectively, these findings highlight biocompatible NCM's potential as novel cardioprotective agent offer promising strategy managing

Language: Английский

Citations

0
Natural products and ferroptosis: A novel approach for heart failure management DOI
Zeyu Zhang, Zhihua Yang, Shuai Wang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156783 - 156783

Published: April 1, 2025

Language: Английский

Citations

0
Baicalin nanofiber membranes: A comprehensive study on preparation, characterization, and antimicrobial pharmacological activities DOI

Weizhao Hou,

Wenjuan Guo, Zhao Dai

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1322, P. 140628 - 140628

Published: Nov. 6, 2024

Language: Английский

Citations

3
Myocardium-targeted liposomal delivery of the antioxidant peptide 8P against doxorubicin-induced myocardial injury DOI

Mei-Jun Zhao,

Chang Liu,

Zhenye Liu

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 663, P. 124569 - 124569

Published: Aug. 8, 2024

Language: Английский

Citations

2