Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 7, 2024
Introduction
The
blood-brain
barrier
(BBB)
is
a
highly
selective
structure
that
protects
the
central
nervous
system
(CNS)
while
hindering
delivery
of
many
therapeutic
agents.
This
presents
major
challenge
in
treating
neurological
disorders,
such
as
multiple
sclerosis,
where
effective
drug
to
brain
crucial
for
improving
patient
outcomes.
Innovative
strategies
are
urgently
needed
address
this
limitation.
Drug Design Development and Therapy,
Journal Year:
2024,
Volume and Issue:
Volume 18, P. 1469 - 1495
Published: May 1, 2024
This
manuscript
offers
a
comprehensive
overview
of
nanotechnology's
impact
on
the
solubility
and
bioavailability
poorly
soluble
drugs,
with
focus
BCS
Class
II
IV
drugs.
We
explore
various
nanoscale
drug
delivery
systems
(NDDSs),
including
lipid-based,
polymer-based,
nanoemulsions,
nanogels,
inorganic
carriers.
These
offer
improved
efficacy,
targeting,
reduced
side
effects.
Emphasizing
crucial
role
nanoparticle
size
surface
modifications,
review
discusses
advancements
in
NDDSs
for
enhanced
therapeutic
outcomes.
Challenges
such
as
production
cost
safety
are
acknowledged,
yet
potential
transforming
methods
is
highlighted.
contribution
underscores
importance
nanotechnology
pharmaceutical
engineering,
suggesting
it
significant
advancement
medical
applications
patient
care.
Industrial & Engineering Chemistry Research,
Journal Year:
2025,
Volume and Issue:
64(4), P. 1907 - 1932
Published: Jan. 14, 2025
Metal–organic
frameworks
(MOFs)
have
been
shown
to
be
great
alternatives
traditional
porous
materials
in
various
chemical
applications,
and
they
very
widely
studied
for
biomedical
applications
the
past
decade
specifically
drug
storage.
After
our
review
published
2011
[Keskin
Kızılel,
Ind.
Eng.
Chem.
Res.
2011,
50
(4),
1799–1812,
10.1021/ie101312k],
we
witnessed
a
fast
growth
not
only
number
variety
of
MOFs
but
also
their
usage
across
broad
spectrum
fields.
With
recent
integration
molecular
modeling
data
science
approaches
experimental
studies,
significantly
accelerated
positioning
them
as
pivotal
components
regenerative
medicine,
medical
imaging,
diagnostics.
In
this
review,
visited
diverse
considering
computational
efforts
on
storage
delivery,
bioimaging,
biosensing.
We
focused
underlying
mechanisms
governing
interactions
between
biological
systems
discussed
both
opportunities
challenges
field
highlight
potential
advanced
therapeutics
cancer
neurological
diseases.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 12, 2024
Biomaterials
are
substances
that
can
be
injected,
implanted,
or
applied
to
the
surface
of
tissues
in
biomedical
applications
and
have
ability
interact
with
biological
systems
initiate
therapeutic
responses.
Biomaterial-based
vaccine
delivery
possess
robust
packaging
capabilities,
enabling
sustained
localized
drug
release
at
target
site.
Throughout
process,
they
contribute
protecting,
stabilizing,
guiding
immunogen
while
also
serving
as
adjuvants
enhance
efficacy.
In
this
article,
we
provide
a
comprehensive
review
contributions
biomaterials
advancement
development.
We
begin
by
categorizing
biomaterial
types
properties,
detailing
their
reprocessing
strategies,
exploring
several
common
systems,
such
polymeric
nanoparticles,
lipid
hydrogels,
microneedles.
Additionally,
investigated
how
physicochemical
properties
routes
influence
immune
Notably,
delve
into
design
considerations
adjuvants,
showcasing
application
development
for
cancer,
acquired
immunodeficiency
syndrome,
influenza,
corona
virus
disease
2019
(COVID-19),
tuberculosis,
malaria,
hepatitis
B.
review,
highlight
successful
instances
where
enhanced
efficacy
discuss
limitations
future
directions
immunotherapy.
This
aims
offer
researchers
understanding
stimulate
further
progress
related
fields.
Molecular Systems Design & Engineering,
Journal Year:
2024,
Volume and Issue:
9(11), P. 1085 - 1106
Published: Jan. 1, 2024
Porous
nanostructures
exhibit
remarkable
nanoplatforms
for
payload
delivery
to
diseased
cells
with
high
loading
capacity,
favorable
release
profiles,
improved
hemocompatibility,
biocompatibility,
and
safe
clearance
after
biodegradation.
