International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139137 - 139137
Published: Dec. 1, 2024
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 23, 2024
Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.
Language: Английский
Citations
8
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: June 27, 2024
Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation differs from death, such as apoptosis, necrosis, autophagy. Ferroptosis associated with variety physiological pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence development diseases targeting metabolic pathways signaling tumors, ischemic organ damage, other degenerative related to peroxidation. Increasing evidence suggests closely linked onset progression various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, retinoblastoma. Our review current research on reveals significant advancements our understanding pathogenesis, aetiology, treatment these conditions.
Language: Английский
Citations
5
Cell Biology International, Journal Year: 2025, Volume and Issue: unknown
Published: March 21, 2025
Programmed cell death (PCD) pathways play a crucial role in maintaining normal turnover and tissue homeostasis, encompassing apoptosis regulated necrosis. However, the involvement of PCD pathogenesis acute kidney disease remains unexplored. In this study, we utilized gene expression profiling datasets (GSE139061) obtained from Gene Expression Omnibus (GEO) database. Through differential analysis weighted co-expression network (WGCNA), identified five key genes associated with PCD, namely DPP4, ATF3, KIT, MSX1, SNAI2 injury (AKI). Subsequently, single sample set enrichment (ssGSEA) was employed to demonstrate correlation between these hub immune infiltration as well activation pathways. Furthermore, validated our findings by analyzing patterns using mouse model ischemia-reperfusion injury. conclusion, study is first propose concept AKI. This finding has significant implications for future investigations into pro-inflammatory mechanisms mediated damage-associated molecular (DAMPs) during stages Our underscore necessity further investigation molecules, which may offer new avenues therapeutic intervention These serve promising targets cases diseases.
Language: Английский
Citations
0
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(17), P. 4335 - 4353
Published: Jan. 1, 2024
Reactive oxygen species (ROS) play a dual role in pathology and therapy. ROS-responsive nanoscale drug carriers offer promising strategy to leverage elevated ROS levels diseased tissues for targeted, enhanced therapeutic delivery efficacy.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 4, 2024
Ferroptosis, a form of regulated cell death distinct from apoptosis, necrosis, and autophagy, is increasingly recognized for its role in skin disease pathology. Characterized by iron accumulation lipid peroxidation, ferroptosis has been implicated the progression various conditions, including psoriasis, photosensitive dermatitis, melanoma. This review provides an in-depth analysis molecular mechanisms underlying compares cellular effects with other forms context health disease. We systematically examine five specific diseases, ichthyosis, polymorphous light eruption (PMLE), vitiligo, melanoma, detailing influence on pathogenesis progression. Moreover, we explore current clinical landscape ferroptosis-targeted therapies, discussing their potential managing treating diseases. Our aim to shed therapeutic modulating research practice.
Language: Английский
Citations
0
Small, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 16, 2024
Abstract Nanozymes with multienzyme‐like activity have sparked significant interest in anti‐tumor therapy via responding to the tumor microenvironment (TME). However, consequent induction of protective autophagy substantially compromises therapeutic efficacy. Here, a targeted nanozyme system (Fe‐Arg‐CDs@ZIF‐8/HAD, FZH) is shown, which enhances synergistic ferroptosis/apoptosis by leveraging machine learning (ML). A novel ML model, termed sequential backward Tree‐Classifier for Gaussian Process Regression (TCGPR), proposed improve data pattern recognition following divide‐and‐conquer principle. Based on this, Bayesian optimization algorithm employed select candidates from extensive search space. Leveraging this fresh material discovery framework, strategy enhancing nanozyme‐based therapy, has been developed. The results reveal that FZH effectively exerts effects sequentially TME, having cascade reaction induce ferroptosis. Moreover, endogenous elevation high concentration nitric oxide (NO) serves as direct mechanism killing cells while concurrently suppressing induced oxidative stress (OS), therapy. Overall, improving proposed, underlying integration ML, experiments, and biological applications.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139137 - 139137
Published: Dec. 1, 2024
Language: Английский
Citations
0