Characterization and evaluation of the cytotoxic, antioxidant, and anti-human lung cancer properties of copper nanoparticles green-synthesized by fennel extract following the PI3K/AKT/Mtor signaling pathway DOI Creative Commons
Tao Huang, Ke Ma, Yihua Wang

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0309207 - e0309207

Published: Jan. 9, 2025

This work established the cytotoxic, antioxidant and anticancer effects of copper nanoparticles (CuNPs) manufactured with fennel extract, especially on non-small cell lung cancer (NSCLC) as well. CuNPs caused cytotoxicity in a dose-dependent manner for two NSCLC lines, A549 H1650. At 100 μg/ml, reduced viability to 70% cells 65% H1650 cells. which showed cytotoxic effect (p<0. 05). Lactate dehydrogenase (LDH) was correspondingly present high proportion cells, demonstrated upon testing. Together their properties, antioxidative activity. When concentration nano particles (100 μg/ml), ratio reactive oxygen species (ROS) much 50%, turn suggested There plenty evidence that had anti-cancer potential; this has been shown by molecules PI3K/AKT/mTOR pathway, one pathways crucial survival. Western blot analysis qRT-PCR results indicated widespread degradation proteins pathway CuNP exposure. Interestingly, there declined phosphorylation up 75% PI3K, AKT, mTOR at μg/ml 001). In summary, these findings illustrated mechanisms behind therapeutic CuNPs, thus making them good targets treatment. have capacity, well significant alterations cancers therefore they can be considered candidates.

Language: Английский

Biofabrication of nanoparticles: sources, synthesis, and biomedical applications DOI Creative Commons
Deepak Kulkarni, Rushikesh S. Sherkar,

Chaitali S. Shirsathe

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: May 2, 2023

Graphical Abstract Sources for biogenic synthesis: The synthesis sources include but are not limited to bacteria, fungi, algae, yeasts, marine and plant sources.

Language: Английский

Citations

118
Eco synthesized chitosan/zinc oxide nanocomposites as the next generation of nano-delivery for antibacterial, antioxidant, antidiabetic potential, and chronic wound repair DOI

Diksha Halarnekar,

Muniappan Ayyanar,

Peramaiyan Gangapriya

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 242, P. 124764 - 124764

Published: May 5, 2023

Language: Английский

Citations

39
Anticancer and antibacterial activity against clinical pathogenic multi-drug resistant bacteria using biosynthesized silver nanoparticles with Mentha pulegium and Crocus caspius extracts DOI
Zahra Hashemi,

Zirar M. Mizwari,

Sedeh Roya Alizadeh

et al.

Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 154, P. 110982 - 110982

Published: June 25, 2023

Language: Английский

Citations

33
Green Biosynthesis of Zinc Oxide Nanoparticles Using Pluchea indica Leaf Extract: Antimicrobial and Photocatalytic Activities DOI Creative Commons
Abdulaziz A. Al–Askar, Amr H. Hashem, Nadeem I. Elhussieny

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(12), P. 4679 - 4679

Published: June 9, 2023

Nanotechnology is playing a critical role in several essential technologies with nanoscale structures (nanoparticles) areas of the environment and biomedicine. In this work, leaf extract Pluchea indica was utilized to biosynthesize zinc oxide nanoparticles (ZnONPs) for first time evaluated antimicrobial photocatalytic activities. Different experimental methods were used characterize biosynthesized ZnONPs. The ZnONPs showed maximum Ultraviolet-visible spectroscopy (UV-vis) absorbance at wavelength 360 nm. X-Ray diffraction (XRD) pattern exhibits seven strong reflection peaks, average particle size 21.9 Fourier-transform infrared (FT-IR) spectrum analysis reveals presence functional groups that help biofabrication. existence Zn O confirmed by Energy-dispersive X-ray (EDX) morphology SEM images. Antimicrobial studies have efficacy against Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Bacillus subtilis, Staphylococcus aureus, Candida albicans Cryptococcus neoformans where inhibition zones concentration 1000 µg/mL 21.83 ± 0.76, 13.0 1.1, 14.9 0.85, 24.26 17.0 1.0, 20.67 0.57 19.0 1.0 mm respectively. Under both dark sunlight irradiation, activity towards degradation thiazine dye (methylene blue-MB). Approximately 95% MB broken down pH 8 after 150 min exposure. aforementioned results, therefore, suggest synthesized implementing environmentally friendly techniques can be employed variety environmental biomedical applications.

Language: Английский

Citations

31
Recent advances in Mushroom-mediated nanoparticles: A critical review of mushroom biology, nanoparticles synthesis, types, characteristics and applications DOI
Naheem Adekilekun Tijani, Joseph Hokello, Kehinde Olusayo Awojobi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 96, P. 105695 - 105695

Published: April 21, 2024

Language: Английский

Citations

10
Updated Review of Metal Nanoparticles Fabricated by Green Chemistry Using Natural Extracts: Biosynthesis, Mechanisms, and Applications DOI Creative Commons
Hesham R. El‐Seedi,

Mohamed S. Omara,

Abdulrahman H. Omar

et al.

Bioengineering, Journal Year: 2024, Volume and Issue: 11(11), P. 1095 - 1095

Published: Oct. 30, 2024

Metallic nanoparticles have found wide applications due to their unique physical and chemical properties. Green biosynthesis using plants, microbes, plant/microbial extracts provides an environmentally friendly approach for nanoparticle synthesis. This review discusses the mechanisms factors governing of metallic such as silver, gold, zinc various plant microorganisms, including bacteria, fungi, algae. The phytochemicals biomolecules responsible reducing metal ions stabilizing are discussed. Key process parameters like pH, temperature, precursor concentration affecting particle size highlighted. Characterization techniques confirming formation properties also mentioned. Applications biosynthesized in areas antibacterial delivery, cancer therapy, biosensors, environmental remediation reviewed. Challenges scaling up production regulating addressed. Power Point 365 was used creating graphics. Overall, green is emerging field with opportunities developing eco-friendly nanomanufacturing platforms abundant natural resources. Further work on optimizing conditions, standardizing protocols, exploring new biosources needed realize full potential this approach.

Language: Английский

Citations

9
Fabrication of chitosan nanocomposites loaded with biosynthetic metallic nanoparticles and their therapeutic investigation DOI

Slavika Gracias,

Muniappan Ayyanar,

Gangapriya Peramaiyan

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 234, P. 116609 - 116609

Published: July 10, 2023

Language: Английский

Citations

21
Effect of optimisation variable and the role of plant extract in the synthesis of nanoparticles using plant-mediated synthesis approaches DOI
Nor Monica Ahmad, Ahmad Husaini Mohamed, Nor’Aishah Hasan

et al.

Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 161, P. 111839 - 111839

Published: Dec. 3, 2023

Language: Английский

Citations

17
Antibacterial activity of extracellular biosynthesized iron oxide nanoparticles against locally isolated β-lactamase-producing Escherichia coli from Egypt DOI Creative Commons
Mohamed Abou-Dobara,

May A. Kamel,

Ahmed El-Sayed

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 6(3)

Published: March 8, 2024

Abstract Nowadays, extended spectrum β-lactamase (ESBL) producing Escherichia coli has been recognized and recorded worldwide as one of the main causing agents a major contributor to nosocomial infections. The current study aimed isolate detect β-lactamase-producing E. use it in extracellular biosynthesis iron oxide nanoparticles (Fe 2 O 3 NPs). Fifteen Gram-negative (G-ve), lactose-fermenting, negative citrate non-spore-forming coliform bacteria were isolated from total bacterial isolates water samples. Different tests performed including chromogenic methods acidimetric iodometric techniques phenotypic cloverleaf test Masuda double-disc test. ESBL-producing was detected confirmed by modified double disc synergy using ceftazidime, cefotaxime, ceftriaxone, amoxicillin combined with clavulanic acid, imipenem, cefepime, cefoxitin. quantitative assay done micro-iodometric assay. Among isolates, S1B1 (the highest activity) selected tested for Fe NPs. produced (NPs) characterized UV–visible spectroscopy, X-ray diffraction analysis, Fourier-transform infrared spectroscopy (FTIR), transmission electron microscope Zeta analysis. Results successful NPs which displayed an absorption peak at 346 nm crystallographic lattice plane (104). negatively charged spherical-shaped average size ≈ 24 ± nm. FTIR refers presence NPs-associated proteins act stabilizing capping agents. Antibacterial activity against Staphylococcus aureus ATCC25923, Bacillus cereus ATCC6633 (G+ve bacterium), Pseudomonas aeruginosa ATCC27853 (G-ve well strain. revealed moderate strong antibacterial action strains minimum inhibition concentration (MIC) ranging 25 40 µg/ml.

Language: Английский

Citations

8
QbD-guided phospholipid-tagged nanonized boswellic acid naturosomal delivery for effective rheumatoid arthritis treatment DOI Creative Commons

Poonam Usapkar,

Suprit D. Saoji,

Pradnya Jagtap

et al.

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 7, P. 100257 - 100257

Published: May 19, 2024

Studies have reported the potential role of Boswellic acids (BAs), bioactive pentacyclic triterpenes from Boswellia serrata, in treating rheumatoid arthritis (RA). However, poor water solubility and limited oral absorption are restricting factors for its better therapeutic efficacy. Based on these assumptions, current study set out to develop naturosomal delivery BAs boost their extremely low bioavailability, colloidal stability, solubility. Nanonized naturosomes were developed subsequently analyzed show physicochemical functional features employing quality-by-design approach. The analysis acid (BSENs) revealed a 16 times improvement aqueous compared BS extract (BSE). zeta dynamic light scattering findings BSENs demonstrated stability with regulated nano-size particles. Additionally, BSE (⁓31%), in-vitro dissolution experiments showed that >99% released BSENs. ex-vivo permeation BSENs' (>79%) significantly improved over BSE's (⁓20%). In-vivo efficacy studies using CFA-prompted rodents critical expansion body wt an undeniable reduction paw thickness, volume, TNF-α treated BSEN control BSE-treated group. These suggest can help treat RA drugs by demonstrating further clinical research validate significant improvements.

Language: Английский

Citations

7