Aptamer-Based Smart Targeting and Spatial Trigger–Response Drug-Delivery Systems for Anticancer Therapy

Biomedicines, Год журнала: 2024, Номер 12(1), С. 187 - 187

Опубликована: Янв. 15, 2024

In recent years, the field of drug delivery has witnessed remarkable progress, driven by quest for more effective and precise therapeutic interventions. Among myriad strategies employed, integration aptamers as targeting moieties stimuli-responsive systems emerged a promising avenue, particularly in context anticancer therapy. This review explores cutting-edge advancements targeted drug-delivery systems, focusing on platforms enhanced spatial aptamer-based we delve into versatile applications aptamers, examining their conjugation with gold, silica, carbon materials. The synergistic interplay between these materials is discussed, emphasizing potential achieving delivery. Additionally, explore an emphasis Tumor microenvironment-responsive nanoparticles are elucidated, capacity to exploit dynamic conditions within cancerous tissues controlled release detailed. External strategies, including ultrasound-mediated, photo-responsive, magnetic-guided examined role effects. integrates diverse approaches precision medicine, showcasing revolutionize

Язык: Английский

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Targeting triple negative breast cancer stem cells using nanocarriers

Discover Nano, Год журнала: 2024, Номер 19(1)

Опубликована: Март 7, 2024

Abstract Breast cancer is a complex and heterogeneous disease, encompassing various subtypes characterized by distinct molecular features, clinical behaviors, treatment responses. Categorization of based on the presence or absence estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2), leading to such as luminal A, B, HER2-positive, triple-negative breast (TNBC). TNBC, comprising around 20% all cancers, lacks expression ER, PR, HER2 receptors, rendering it unresponsive targeted therapies presenting significant challenges in treatment. TNBC associated with aggressive behavior, high rates recurrence, resistance chemotherapy. Tumor initiation, progression, are attributed stem cells (BCSCs), which possess self-renewal, differentiation, tumorigenic potential. Surface markers, self-renewal pathways (Notch, Wnt, Hedgehog signaling), apoptotic protein (Bcl-2), angiogenesis inhibition (VEGF inhibitors), immune modulation (cytokines, checkpoint inhibitors) among key targets discussed this review. However, targeting BCSC subpopulation presents challenges, including off-target effects, low solubility, bioavailability anti-BCSC agents. Nanoparticle-based offer promising approach target cellular processes implicated survival BSCS TNBC. In review, we explore nanocarrier-based approaches for BCSCs aiming overcome these improve outcomes patients. These nanoparticle-based therapeutic strategies hold promise addressing gap delivering while minimizing systemic toxicity enhancing efficacy. Graphical abstract

Язык: Английский

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Polymer mediated light responsive therapeutics delivery system to treat cancer

European Polymer Journal, Год журнала: 2024, Номер 210, С. 112923 - 112923

Опубликована: Март 12, 2024

Язык: Английский

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Metallic nanoparticles in cancer: Types, green synthesis, applications, tumor microenvironment and toxicity considerations

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 92, С. 105307 - 105307

Опубликована: Дек. 29, 2023

Язык: Английский

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Improving synthesis and binding affinities of nucleic acid aptamers and their therapeutics and diagnostic applications

Biophysical Chemistry, Год журнала: 2024, Номер 309, С. 107218 - 107218

Опубликована: Март 21, 2024

Язык: Английский

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Lab on chip based self-adjustable liposomes for rapid wound healing: An in depth in vitro, in vivo and higher dose toxicity investigation

Biomaterials Advances, Год журнала: 2024, Номер 158, С. 213777 - 213777

Опубликована: Янв. 19, 2024

Язык: Английский

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Recent advancements in aptamers as promising nanotool for therapeutic and diagnostic applications

Analytical Biochemistry, Год журнала: 2025, Номер unknown, С. 115844 - 115844

Опубликована: Март 1, 2025

Язык: Английский

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Emerging Biopolymer Nanocarriers for Controlled and Protective Delivery of Food Bioactive Compounds- Current Status and Future Perspective

Food Hydrocolloids, Год журнала: 2024, Номер 160, С. 110769 - 110769

Опубликована: Окт. 22, 2024

Язык: Английский

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Niosomes based formulation containing tenoxicam: A newer solution for the rheumatic diseases

Annales Pharmaceutiques Françaises, Год журнала: 2023, Номер 82(3), С. 473 - 482

Опубликована: Ноя. 3, 2023

Язык: Английский

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Photoresponsive ‘Chemo-Free’ Phytotherapy: Formulation Development For the Treatment of Triple-Negative Breast Cancer

Nanomedicine, Год журнала: 2024, Номер 19(1), С. 5 - 24

Опубликована: Янв. 1, 2024

Aim: The present investigation aimed to develop a chemo-free, nanophytosomal system treat triple-negative breast cancer (TNBC) via phyto–photo dual treatment strategy. Method: Size, shape, surface analysis, photoprovoked release profile, photothermal stability, (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide assay, apoptotic DNA fragmentation, in vitro cellular uptake evaluation, mitochondrial membrane potential and caspase-3 photodynamic evaluation. Results: Biological experiments using MDA-MB-231 cells displayed dose-dependent synergistic anti-TNBC activity of PhytoS/Houttuynia cordata extract (HCE)/IR780 as compared with Phyto/HCE, PhytoS/IR780 even more promising under laser treatment. Apoptotic assay fragmentation analysis also showed enhanced effects. Investigation found that HCE acts suppression inducing cells. Conclusion: Our findings suggested photo-empowered phytotherapy can be employed effectively safely against TNBC.

Язык: Английский

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